Ocular Oncology

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ISBN: 9780824740160 | 0824740165
Cover: Hardcover
Copyright: 8/26/2003

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Univ. of Wisconsin, Madison. Presents a comprehensive account of the most current basic and clinical science related to eye tumors and offers new ideas about treatments derived from recent genetic, biochemical, and immunological studies. Discusses the epidemiology, determinants of tumor phenotype, immunotherapy, treatment methods, and patient prognosis.

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Preface	p. v
Contributors	p. xi
Clinical Overview of Uveal Melanoma: Introduction to Tumors of the Eye	p. 1
Clinical Overview: Retinoblastoma	p. 19
Epidemiology of Uveal Melanoma: Patient Characteristics, Risk Factors, and Predisposing Elements	p. 35
Epidemiology of Retinoblastoma	p. 47
Genetics of Uveal Melanoma: Chromosomal Rearrangements and the Identification of Genes Involved in Tumorigenesis	p. 63
Structural Alterations and Gene Expression in the Pathogenesis of Uveal Melanoma	p. 81
A Cascade of Genomic Changes Leads to Retinoblastoma	p. 103
The Role of the Retinoblastoma Protein in Health, Malignancy, and the Pathogenesis of Retinoblastoma	p. 129
Biochemical Pathways: Differential Gene Expression and Cellular Pathways Determining Tumor Phenotype Comparison of Uveal Melanocytes and Uveal Melanoma Cells In Vitro	p. 189
p53 and the Molecular Regulation of Cell Fate in Retinoblastoma	p. 211
Immunology of Uveal Melanoma: Adaptive Antitumor Immunity and the Basis for Immunotherapy	p. 231
Immunology of Uveal Melanoma: Immunosuppressive Factors and the Basis for Immunotherapy	p. 255
Models of Uveal Melanoma: Characterization of Transgenic Mice and Other Animal Models for Melanoma	p. 269
Using Retinoblastoma Models to Develop New Treatment: Vitamin D Analogues	p. 297
Therapy of Uveal Melanoma: Methods and Risk Factors Associated with Treatment	p. 321
The Treatment of Retinoblastoma	p. 353
Clinical Trials in Uveal Melanoma: Patient Characteristics and the Treatment of Intraocular Tumors	p. 377
Clinical Trials in Retinoblastoma	p. 401
Pathology of Uveal Melanoma: Histological Parameters and Patient Prognosis	p. 407
Retinoblastoma: Pathology and Prognosis	p. 427
Molecular Genetics of Retinoblastoma	p. 449
Genetically Engineered Mouse Models of Retinoblastoma	p. 465
Treatment of Extraocular Retinoblastoma	p. 489
Index	p. 499
Table of Contents provided by Rittenhouse. All Rights Reserved.

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Ocular Oncology

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