Osteoporosis

Mayo Foundation, Rochester, Minnesota. Second edition of a reference on the basic science and clinical aspects of osteoporosis, for practitioners, residents, and researchers. Previous edition 1988. Clinical aspects include quality of life, rehabilitation, and menopause management.

Contributing Authors

ix

Preface to the First Edition

xiii

Preface

xv

Part I. Basic Science

The Cells of Bone

1

(40)

Gideon A. Rodan

Sevgi B. Rodan

Biochemistry of Bone

41

(26)

Pamela Gehron Robey

Bone Remodeling

67

(26)

David W. Dempster

Biomechanics of Fractures

93

(22)

Wilson C. Hayes

Elizabeth R. Myers

Part II. Pathophysiology

Inadequate Peak Bone Mass

115

(18)

Robert P. Heaney

Velimir Matkovic

Estrogen Deficiency

133

(28)

Robert Lindsay

Age-Related Factors

161

(22)

Aubrey Blumshon

Richard Eastell

Secondary Osteoporosis

183

(22)

Sundeep Khosla

L. Joseph Melton III

Part III. Clinical Presentation

Clinical Spectrum

205

(20)

Sundeep Khosla

B. Lawrence Riggs

L. Joseph Melton III

Epidemiology of Fractures

225

(24)

L. Joseph Melton III

Part IV. Diagnosis

Radiological Aspects

249

(26)

Cornelis van Kuijk

Harry K. Genant

Bone Densitometry

275

(24)

C. Conrad Johnston, Jr.

L. Joseph Melton III

Bone Histomorphometry

299

(20)

Pierre J. Meunier

Biochemical Markers for the Assessment of Bone Turnover

319

(16)

Pierre D. Delmas

Part V. Management

Prevention

335

(16)

Bess Dawson-Hughes

Management of Menopause

351

(20)

Sanjay K. Agarwal

Howard L. Judd

Drug Therapy: Calcium and Vitamin D

371

(20)

J. Christopher Gallagher

Drug Therapy: Calcitonin, Bisphosphonates, and Anabolic Steroids

391

(12)

Charles H. Chesnut III

Drug Therapy: Formation-Stimulating Regimens

403

(32)

Eric F. Eriksen

Flemming Melsen

Leif Mosekilde

Musculoskeletal Rehabilitation

435

(40)

Mehrsheed Sinaki

Quality of Life

475

(12)

Deborah T. Gold

Mark K. Drezner

Practical Clinical Management

487

(16)

B. Lawrence Riggs

Sundeep Khosla

Subject Index

503

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Summary

Table of Contents

Supplemental Materials