Pharmaceutical Biotechnology Concepts and

Pharmaceutical Biotechnology offers students taking Pharmacy and related Medical and Pharmaceutical courses a comprehensive introduction to the fast-moving area of biopharmaceuticals. With a particular focus on the subject taken from a pharmaceutical perspective, initial chapters offer a broad introduction to protein science and recombinant DNA technology- key areas that underpin the whole subject. Subsequent chapters focus upon the development, production and analysis of these substances. Finally the book moves on to explore the science, biotechnology and medical applications of specific biotech products categories. These include not only protein-based substances but also nucleic acid and cell-based products. introduces essential principles underlining modern biotechnology- recombinant DNA technology and protein science an invaluable introduction to this fast-moving subject aimed specifically at pharmacy and medical students includes specific 'product category chapters' focusing on the pharmaceutical, medical and therapeutic properties of numerous biopharmaceutical products. entire chapter devoted to the principles of genetic engineering and how these drugs are developed. includes numerous relevant case studies to enhance student understanding no prior knowledge of protein structure is assumed

Dr Gary Walsh: University of Limerick, Ireland

Preface
Acronyms
Pharmaceuticals, biologics and biopharmaceuticals
Introduction to pharmaceutical products
Biopharmaceuticals and pharmaceutical biotechnology
History of the pharmaceutical industry
The age of biopharmaceuticals
Biopharmaceuticals: current status and future prospects
Protein structure
Introduction
Overview of protein structure
Higher level structure
Protein stability and folding
Protein post-translational modifi cation
Gene manipulation and recombinant DNA technology
Introduction
Nucleic acids: function and structure
Recombinant production of therapeutic proteins
Classical gene cloning and identifi cation
The drug development process
Introduction
Discovery of biopharmaceuticals
The impact of genomics and related technologies upon drug discovery
Gene chips
Proteomics
Structural genomics
Pharmacogenetics
Initial product characterization
Patenting
Delivery of biopharmaceuticals
Nasal, transmucosal and transdermal delivery systems
Preclinical studies
Pharmacokinetics and pharmacodynamics
Toxicity studies
The role and remit of regulatory authorities
Conclusion
Sources and upstream processing
Introduction
Sources of biopharmaceuticals
Upstream processing
Downstream processing
Introduction
Initial product recovery
Cell disruption
Removal of nucleic acid
Initial product concentration
Chromatographic purifi cation
High-performance liquid chromatography of proteins
Purifi cation of recombinant proteins
Final product formulation
Product analysis
Introduction
Protein-based contaminants
Removal of altered forms of the protein of interest from the product stream
Detection of protein-based product impurities
Immunological approaches to detection of contaminants
Endotoxin and other pyrogenic contaminants
The cytokines: The interferon family
Cytokines
Cytokine receptors
Cytokines as biopharmaceuticals
The interferons
Interferon biotechnology
Conclusion
Cytokines: Interleukins and tumour necrosis factor
Introduction
Interleukin-2
Interleukin-1
Interleukin-11
Tumour necrosis factors
Growth factors
Introduction
Haematopoietic growth factors
Growth factors and wound healing
Therapeutic hormones
Introduction
Insulin
Glucagon
Human growth hormone
The gonadotrophins
Medical and veterinary applications of gonadotrophins
Additional recombinant hormones now approved
Conclusion
Recombinant blood products and therapeutic enzymes
Introduction
Haemostasis
Anticoagulants
Thrombolytic agents
Enzymes of therapeutic value
Antibodies, vaccines and adjuvants
Introduction
Traditional polyclonal antibody preparations
Monoclonal antibodies
Vaccine technology
Adjuvant technology
Nucleic-acid- and cell-based therapeutics
Introduction
Gene therapy
Vectors used in gene therapy
Gene therapy and genetic disease
Gene therapy and cancer

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Pharmaceutical Biotechnology Concepts and Applications

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