The Pharmacologic Basis of Psychotherapeutics

First in an unnamed series of pharmacopsychology texts specifically written for psychologists and graduate psychology students on the basic principles and concepts of pharmacotherapy. Prerequisite to the rest of series. To be completed in three volumes.

Special Guest Authors

ix

(1)

Editorial Advisory Committee

ix

(4)

List of Figures

xiii

(2)

List of Tables

xv

(2)

Foreword

xvii

(8)

Preface

xxv

(4)

Acknowledgments

xxix

CHAPTER 1 INTRODUCTION TO THE BASIC PRINCIPLES OF PHARMACOTHERAPY

1

(24)

Introduction

1

(4)

Mechanisms of drug action

5

(6)

Age-dependent drug selection and response

11

(12)

Summary

23

(2)

CHAPTER 2 THE PSYCHOTROPICS

25

(46)

Introduction

25

(1)

Antidepressants and antimanics

26

(10)

Antipsychotics

36

(10)

Sedative-hypnotics

46

(11)

Opiate analgesics and antagonists

57

(8)

Amphetamines and other central nervous system stimulants

65

(4)

CNS stimulant section summary

69

(1)

Summary

70

(1)

CHAPTER 3 PHARMACOKINETICS AND PHARMACODYNAMICS

71

(28)

Introduction

71

(1)

Input: The serum concentration-time curve

72

(5)

Distribution

77

(1)

Output

78

(12)

Application

90

(3)

Therapeutic drug monitoring

93

(1)

Effect of age

94

(1)

Effect of disease

95

(3)

Summary

98

(1)

CHAPTER 4 ADMINISTRATION OF PSYCHOTROPICS

99

(52)

Introduction

99

(1)

Oral dosage forms

100

(8)

Sublingual and other transmucosal dosage forms

108

(3)

Rectal dosage forms

111

(1)

Intranasal dosage forms

112

(2)

Transdermal dosage forms

114

(3)

Injectable dosage forms

117

(30)

The confused, mentally retarded, or psychotic patient

147

(1)

Summary

148

(3)

CHAPTER 5 ADVERSE DRUG REACTIONS

151

(30)

Introduction

151

(4)

Allergic, idiosyncratic, and pharmacologic ADRs

155

(4)

Toxic ADRs

159

(1)

ADRs associated with various drug interactions

160

(1)

ADRs involving specific body organ systems

160

(19)

Summary

179

(2)

CHAPTER 6 DRUG INTERACTIONS

181

(12)

Introduction

181

(1)

Types of drug interactions

181

(11)

Summary

192

(1)

REFERENCES

193

(10)

APPENDIX 1 Abbreviations

203

(4)

APPENDIX 2 Glossary

207

(12)

APPENDIX 3 Commonly Prescribed Psychotropics-Associated ADRs and Clinical Comments

219

(12)

APPENDIX 4 Major Clinically Significant Drug Interactions Involving the Psychotropics

231

(22)

Index

253

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The Pharmacologic Basis of Psychotherapeutics

Summary

Table of Contents

Supplemental Materials