Postmenopausal Osteoporosis: Hormones & Other Therapies

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ISBN: 9781842143117 | 1842143115
Cover: Hardcover
Copyright: 1/17/2006

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The book is the first major review of menopause-associated osteoporosis, post WHI. The book has in-depth sections on the pathogenesis, epidemiology, and diagnosis of osteoporosis. The chief focus is on medical prevention and treatment, and includes chapters on hormone replacement therapy, bisphosphonates, selective estrogen receptor modulators (SERMs), vitamin D derivatives, calcium supplements, androgens, and tibolone.

List of contributors

Preface

Section I: Introduction

Magnitude and impact of osteoporosis and fractures

(10)

C. Marcocci

F. Cetani

E. Vignali

A. Pinchera

Impact of osteoporosis on quality of life and quality of life on osteoporosis: rationale and methodology for accurate assessment

(6)

W. H. Utian

Section II: Gonadal steroids and the pathogenesis of osteoporosis

Novel signals determining skeletal cell fate and function

(6)

E. Canalis

V. Deregowski

R. C. Pereira

E. Gazzerro

Sex steroid hormones and bone formation

(8)

R. Civitelli

The effect of sex steroids on osteoclast function

(14)

K. Henriksen

N. A. Sims

L. B. Tanko

M. A. Karsdal

Calcium and vitamin D: regulation of mineral homeostasis

(10)

D. Goltzman

Section III: Epidemiology

Genetic regulation of bone mass

(8)

S. H. Ralston

Bone mineral acquisition during infancy and adolescence

(8)

G. Saggese

G. I. Baroncelli

Osteoporosis: influence of life-style

(6)

R. Rizzoli

Postmenopausal osteoporosis and dental health

(20)

J. Wactawski-Wende

Section IV: Diagnosis

Bone quality

(6)

C. E. Bogado

Diagnosis: clinical, hormonal and biochemical evaluation

103

(10)

D. M. Reid

Advanced imaging assessment of bone quality

113

(14)

H. K. Genant

Y. Jiang

Quantitative ultrasonometry of bone in the management of postmenopausal women

127

(14)

P. Hadji

Section V: Pharmacological prevention and treatment

Awareness of osteoporosis and related treatments

141

(4)

A. D. Woolf

Intervention thresholds for osteoporosis

145

(6)

J. A. Kanis

Vitamin D and calcium supplements

151

(20)

R. Nuti

L. Gennari

D. Merlotti

G. Martini

Estrogen dose response in bone density and bone histology

171

(6)

E. Horner

J. Studd

Effects of oral contraceptive preparation on bone health

177

(8)

M. Gambacciani

Hormone replacement therapy

185

(8)

L. B. Tanko

C. Christiansen

New physiologic approach to prevention of postmenopausal osteoporosis

193

(10)

B. Ettinger

J. S. Lee

Selective estrogen receptor modulators

203

(6)

A. Diez-Perez

Bisphosphonates in the management of osteoporosis

209

(10)

S. E. Papapoulos

Phytoestrogens: food or drug?

219

(14)

L. Bacciottini

A. Falchetti

B. Pampaloni

E. Bartolini

A. M. Carossino

M. L. Brandi

Tibolone

233

(6)

M. R. McClung

Understanding the role of aromatizable androgens in bone-sparing

239

(8)

O. Tuncalp

V. Edusa

A. Fadiel

F. Naftolin

Section VI: Specific aspects of selected therapies

Strontium ranelate: a new first-line treatment for patients with postmenopausal osteoporosis

247

(8)

S. Ortolani

Reconciling risks and benefits of hormone replacement therapy in a single outcome: the QALY approach

255

(8)

J. M. Alt

Y. Zollner

J. Ryan

Prevent, treat and maintain: how to optimize the management of postmenopausal osteoporosis

263

(8)

D. Agnusdei

Transdermal hormone therapy: effects on bone

271

(4)

R. E. Nappi

F. Albani

F. Ferdeghini

S. Detaddei

A. Sommacal

A. Verza

A. Ornati

F. Polatti

Progestogens and bone

275

(6)

D. W. Sturdee

Effect of different dose options of continuous combined hormone therapy on bone and bone marker N-terminal propeptide of type I procollagen: results from a long-term study in Finnish postmenopausal women

281

(8)

J. Heikkinen

J. Haapalahti

The use of alendronate in osteoporosis treatment: 10-year experience

289

(14)

M. L. Brandi

Index

303