Protein Discovery Technologies

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ISBN: 9780824754686 | 0824754689
Cover: Hardcover
Copyright: 7/28/2009

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Until now, there has not been a book that effectively addresses the historical basis of protein discovery. Featuring contributions from a distinguished international panel of experts, Protein Discovery Technologies elucidates the principles, techniques, strategies, and broad range of applications of protein discovery by documenting the often untold stories and personal accounts of the contributors' past scientific achievements.

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Preface	p. ix
Editors	p. xi
Contributors	p. xiii
Discovery of Vascular Permeability Factor (VPF, VEGF, VPF/VEGF, VEGF-A165)	p. 1
Tumor Necrosis Factor and Its Family Members	p. 15
Blood-Brain Barrier Models for Investigating CNS Pathologies	p. 55
Identification of Activation of Latent TGFß as Principal In Vivo Function of Integrin ¿vß	p. 67
Purification of Basic Fibroblast Growth Factor by Heparin Affinity	p. 81
How It Came to Pass That Interferon Was Used as an Angiogenesis Inhibitor	p. 87
Use of Phage Display to Discovery Inhibitors of Cell Migration	p. 91
Combinatorial Mapping of Vascular Zip Codes by In Vivo Phage Display	p. 99
Chasing Elusive Cellular Prion Protein Receptor	p. 113
Discovery of Molecular Chaperone GRP78 and GRP94 Inducible by Endoplasmic Reticulum Stress	p. 129
Origin of Sphingomyelin Pathway	p. 141
Endotoxin-Induced Myocarditis: A New Pathophysiological Entity in Systemic Inflammatory Response Syndrome	p. 157
Discovery of DOCK180 Superfamily of Exchange Factors	p. 171
Discovery of Extracellular Matrix Degradome as Novel Endogenous Regulators of Angiogenesis and Tumor Growth	p. 191
RING Finger Proteins as E3 Ubiquitin Ligases	p. 203
Discovery of Chemical Nature of Cross-Links in Collagen: A Personal Retrospective	p. 215
Discovery of SPARC as Prototype for Matricellular Proteins	p. 223
Index	p. 239
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Protein Discovery Technologies

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