Restless Legs Syndrome: Diagnosis and Treatment

Note: Supplemental materials are not guaranteed with Rental or Used book purchases.

ISBN: 9780849336140 | 0849336147
Cover: Hardcover
Copyright: 10/4/2006

Rent

(Recommended)

$151.41

Term

Due

Price

Semester

Aug 2

$151.41

Quarter

Jul 19

$143.84

Short Term

Jun 21

$136.27

*This item is part of an exclusive publisher rental program and requires an additional convenience fee. This fee will be reflected in the shopping cart.
Buy Used

Usually Ships in 2-4 Business Days

$154.35
Buy New

Usually Ships in 3-5 Business Days

$206.86
eBook

Available Instantly

Online: 180 Days

Downloadable: 180 Days

$49.48

The most authoritative and comprehensive guide on RLS to date, this expertly written source examines the pathogenesis, diagnosis, and treatment of a condition affecting nearly 10% of the population. Ranging from basic science to therapeutics, Restless Legs Syndrome analyzes the many new and emerging medications impacting the management of this disorder and strives to address the explosion of research in the field.

Preface

Contributors

xvii

Section I: Basic Science

Overview of Sleep

(14)

Allison V. Chan

Clete A. Kushida

Introduction

(1)

Normal Sleep Architecture and Sleep Stages

(2)

Ontogeny of Sleep

(1)

Adequate Sleep

(1)

Sleep Deprivation

(1)

Phylogeny of Sleep

(1)

Physiological Determinants of Sleep

(3)

Biochemical Determinants of Sleep

(1)

Sleep Disorders Classification

(2)

Summary

(1)

References

(5)

The Brain's Dopamine Systems and Their Relevance to Restless Legs Syndrome

(16)

Alon A. Freeman

David B. Rye

Synthesis and Metabolism of Dopamine

(3)

Physiological Effects of Dopamine (Cellular and Subcellular)

(1)

Functional Anatomy of Central Dopamine Systems

(3)

Circadian and Homeostatic Influences upon Central Dopamine Signaling

(1)

Summary: Dopamine in ``State'' Control and Its Relevance to Restless Legs Syndrome/Periodic Limb Movements

(2)

References

(6)

Circadian Physiology

(18)

Mauro Manconi

Luigi Ferini-Strambi

Introduction

(1)

Entrainment Effect of Light-Dark Alternation

(1)

Suprachiasmatic Nucleus

(2)

Melatonin

(3)

Circadian and Homeostatic Control of Sleep

(1)

Circadian Pattern of Restless Legs Syndrome/Periodic Limb Movements

(4)

References

(7)

Systemic Iron Regulation

(12)

John Beard

Introduction

(1)

Regulation of Absorption

(3)

Control of Central Nervous System Iron

(1)

Iron Losses

(4)

References

(3)

The Physiology of Restless Legs Syndrome

(28)

Stephany Fulda

Thomas-Christian Wetter

Introduction

(2)

Pathophysiology of Restless Legs Syndrome

(1)

What is the Role of Peripheral Neuropathy in Restless Legs Syndrome?

(1)

The Vascular Hypothesis---Exotic but Persisting?

(1)

The Spinal Cord

(2)

The Brain

(4)

Other Systems Relevant to Restless Legs Syndrome

(4)

Concluding Remarks

(2)

References

(11)

Progress in the Animal Models of Restless Legs Syndrome

(12)

Weidong Le

Hongru Zhao

William G. Ondo

Introduction

(1)

6-Hydroxydopamine--Lesioned Rat Model

(1)

6-OHDA-Lesioned and Iron-Deficient Mice

(3)

Dopamine D3 Receptor Knockout (D3KO) Mice Model

(2)

An Animal Model of Periodic Limb Movements of Sleep

(2)

Animal Models of Opioid Dopaminergic Interactions

(1)

References

(4)

Pathology of Restless Legs Syndrome

101

(10)

James R. Connor

Xinsheng Wang

Introduction

101

(1)

Neuropathological Evaluation

101

(2)

Iron Management Proteins

103

(2)

Proposed Consequences of Insufficient Iron in the Restless Legs Syndrome Substantia Nigra

105

(1)

Conclusion

106

(1)

References

107

(4)

Genetics of Restless Legs Syndrome

111

(14)

Shaoqi Rao

Juliane Winkelmann

Qing K. Wang

Overview

111

(1)

Prevalence and Environmental Factors

111

(1)

Family History

112

(2)

Inheritance Models and Segregation Analysis

114

(1)

Familial Aggregation Analysis

114

(3)

Twin Studies

117

(1)

Linkage Studies

118

(2)

Genetic Association Studies

120

(1)

Conclusion and Outlook

121

(1)

References

121

(4)

Section II: Clinical Diagnosis

Consequences of Sleep Deprivation

125

(14)

Li Ling Lim

Nancy Foldvary-Schacfer

Introduction

125

(1)

Human Experimental Sleep Deprivation

126

(6)

Animal Sleep Deprivation Studies

132

(1)

Conclusions

133

(1)

References

133

(6)

History of Restless Legs Syndrome

139

(8)

Wayne A. Hening

Early Descriptions of Conditions Resembling Restless Legs Syndrome

139

(1)

The Work of Karl Ekbom

140

(1)

The Naming of Restless Legs

140

(1)

Nocturnal Myoclonus, Now Called Periodic Limb Movements

140

(1)

Early Therapeutic Trials of RLS

141

(1)

The RLS Foundation and the International RLS Study Group

141

(1)

Recent Development on Many Fronts

142

(1)

Summary Thoughts

143

(1)

References

144

(3)

Restless Legs Syndrome: Diagnostic Criteria and Differential Diagnosis

147

(12)

Shahul Hameed

E. K. Tan

Introduction

147

(1)

Diagnostic Criteria

147

(6)

Differential Diagnosis

153

(2)

Evaluation of the Restless Legs Syndrome Patient

155

(1)

Conclusions

156

(1)

References

156

(3)

Occurrence of Restless Legs Syndrome

159

(12)

Jan Ulfberg

Bjorn Bjorvatn

Introduction

159

(1)

The Occurrence of Restless Legs Syndrome---Studies on Populations

160

(2)

Restless Legs Syndrome in Pregnancy

162

(3)

Restless Legs Syndrome and Parkinson's Disease

165

(1)

Restless Legs Syndrome in End-Stage Renal Disease

166

(1)

References

167

(4)

Childhood-Onset Restless Legs Syndrome

171

(8)

Suresh Kotagal

Michael H. Silber

History

171

(1)

Clinical Features

171

(1)

Pathogenesis

172

(3)

Diagnosis

175

(1)

Treatment

175

(2)

Future Directions

177

(1)

References

177

(2)

Periodic Limb Movements and Periodic Limb Movement Disorder

179

(20)

Margaret Park

Cynthia L. Comella

Introduction

179

(3)

Epidemiology of Periodic Limb Movements Disorder

182

(1)

Associated Diseases States

183

(3)

Pathophysiology

186

(2)

Imaging Studies

188

(1)

Treatment

189

(2)

References

191

(8)

Restless Legs Syndrome Effects on Quality of Life

199

(6)

Richard P. Allen

Introduction

199

(1)

Disease-Specific Quality of Life Evaluations of RLS

199

(1)

General Health-Related Quality of Life Evaluations

200

(1)

Treatment Benefits for Quality of Life

201

(1)

Summary

202

(1)

References

202

(3)

Restless Legs Syndrome: Personal Perspectives

205

(6)

Georgianna Bell

The Faces of Restless Legs Syndrome

205

(1)

The RLS Foundation

205

(1)

Marlene's Story: ``Good Physicians Make All the Difference''

206

(1)

Lynne's Story: ``I Want to Live with Them, Not Them Live Around Me''

206

(1)

Clare's Story: ``I Found a Way of Shutting It All Out''

207

(1)

Mike's Story: ``Sleep Deprivation and Work Are an Incompatible Combination''

208

(1)

Sue's Story: ``I Want Better for Them''

208

(1)

Jocelle's Story: ``Never Give Up!''

209

(2)

Section III: Secondary Restless Legs Syndrome

Iron Deficiency---Associated Restless Legs Syndrome

211

(8)

William G. Ondo

Introduction

211

(1)

Central Nervous System Iron Deficiency in RLS

211

(2)

Clinical Experience

213

(1)

Iron Deficiency and Other Associations of Restless Legs Syndrome

214

(1)

Iron Replacement

215

(1)

References

216

(3)

Restless Legs Syndrome and Renal Failure

219

(10)

Kai Ming Chow

David Shu Cheong Hui

Introduction

219

(1)

Epidemiology

219

(2)

Pathogenesis

221

(1)

Diagnosis

222

(2)

Treatment

224

(1)

Prognosis

225

(1)

Summary

226

(1)

References

226

(3)

Restless Legs Syndrome and Neuropathy/Myelopathy

229

(10)

Birgit Hogl

Werner Poewe

Introduction

229

(1)

Polyneuropathy, Radiculopathy, and Peripheral Nerve Lesions

229

(5)

Possible Interpretations of the Evidence

234

(1)

References

235

(4)

Restless Legs Syndrome in Pregnancy

239

(8)

Luigi Ferini-Strambi

Mauro Manconi

Introduction

239

(1)

Epidemiology

240

(1)

Clinical Course

241

(1)

Etiopathogenetic Hypotheses

242

(2)

Treatment

244

(1)

References

245

(2)

Restless Legs Syndrome and Parkinson's Disease

247

(8)

Vandana Dhawan

K. Ray Chaudhuri

Background

247

(1)

Pathophysiology

247

(2)

Clinical Surveys

249

(2)

Conclusions

251

(1)

References

252

(3)

Iatrogenic Restless Legs Syndrome

255

(14)

Changkook Yang

John W. Winkelman

Introduction

255

(1)

Antidepressants

256

(2)

Antipsychotics

258

(2)

Histamine-Receptor Antagonists

260

(1)

Lithium

261

(1)

Antiepileptics

261

(1)

Smoking

261

(1)

Caffeine

262

(1)

Alcohol

262

(1)

Miscellaneous

262

(1)

Augmentation

263

(1)

Conclusion

263

(1)

References

264

(5)

Other Restless Legs Syndrome Associations

269

(6)

Irfan Lalani

William G. Ondo

Introduction

269

(1)

Rheumatological Disorders

269

(1)

Ataxia

270

(1)

Tremor

271

(1)

Tourette's Syndrome

271

(1)

Multiple Sclerosis

272

(1)

Sleep Apnea

272

(1)

Miscellaneous Associations

273

(1)

Conclusion

273

(1)

References

273

(2)

Section IV: Treatment of Restless Legs Syndrome

Treatment Overview

275

(12)

William G. Ondo

Scales for Restless Legs Syndrome

275

(3)

Treatment Overview

278

(2)

References

280

(2)

Appendix A

282

(2)

Appendix B

284

(1)

Appendix C

285

(2)

Dopaminergic Therapy for Restless Legs Syndrome

287

(18)

Philip M. Becker

Introduction

287

(1)

Proposed Therapeutic Action

287

(1)

Pharmacology of Common Dopaminergic Agents

288

(9)

Investigational Dopamine Agonists

297

(1)

Augmentation Due to Dopaminergic Therapy

298

(1)

Conclusion

299

(1)

References

300

(5)

Dopaminergic Augmentation

305

(10)

Diego Garcia-Borreguero

Oscar Larrosa

Renata Egatz

Belen Cabrero

Patrick Troster

Introduction

305

(1)

Clinical Description and Significance

305

(2)

Augumentation Under Dopaminergic Agents

307

(1)

Augmentation Under Nondopaminergic Agents

307

(1)

The Pathophysiology of Augmentation

307

(2)

Measurement of Augmentation

309

(1)

Differential Diagnosis of Augmentation

310

(2)

Treatment of Augmentation

312

(1)

References

312

(3)

Opioids and the Restless Legs Syndrome: Treatment and Pathogenetic Considerations

315

(10)

Arthur S. Walters

Introduction

315

(1)

Therapeutic Trials of Opioids in Restless Legs Syndrome/Periodic Limb Movements

315

(2)

Overall Therapeutic Recommendations

317

(1)

Role of the Endogenous Opiate System in the Pathogenesis of the Restless Legs Syndrome/Periodic Limb Movements

318

(2)

Implications of the Receptor Blocking Studies

320

(1)

Other Evidence Supporting a Role of the Endogenous Opiate System in the Pathogenesis of Restless Legs Syndrome

320

(2)

References

322

(3)

Iron Therapy in Restless Legs Syndrome

325

(10)

Charlene E. Gamaldo

Christopher J. Earley

Introduction

325

(1)

Oral Iron Therapy

325

(3)

Intravenous Iron Therapy

328

(4)

Follow-up

332

(1)

References

332

(3)

Other Therapies in Restless Legs Syndrome

335

(10)

Joohi Shahed

William G. Ondo

Introduction

335

(1)

Antiepileptics

335

(3)

Clonidine

338

(1)

Benzodiazepines

338

(1)

Other Drugs

339

(1)

Nonpharmacologic Therapies

340

(1)

Conclusions

341

(1)

References

341

(4)

Section V: Future Directions in Restless Legs Syndrome

Future Directions

345

(6)

William G. Ondo

Introduction

345

(1)

Diagnosis

345

(1)

Epidemiology

346

(1)

Disease Associations

347

(1)

Pathology

347

(1)

Treatment

348

(1)

Summary

349

(1)

References

349

(2)

Index

351

Please wait while the item is added to your bag...

FREE SHIPPING

Amazon no longer offers textbook rentals. We do!

Restless Legs Syndrome: Diagnosis and Treatment

Summary

Table of Contents

Supplemental Materials