Review Of Medical Microbiology and Immunology

There's no faster or more effective way to prepare for the USMLE Step 1 and course exams than Medical Microbiology & Immunology Examination. Completely updated throughout, the Ninth Edition offers a concise, high-yield review of the basic and clinical aspects of bacteriology, virology, mycology, parasitology, and immunology, with an emphasis on the clinical application of microbiology and immunology to infectious diseases.

Warren Levinson, MD PhDProfessor of Microbiology and ImmunologyUCSF

Preface

vii

Acknowledgments

ix

How to Use This Book

x

I. BASIC BACTERIOLOGY

1

(101)

Bacteria Compared With Other Microorganisms

1

(3)

Structure of Bacterial Cells

4

(11)

Growth

15

(2)

Genetics

17

(6)

Classification of Medically Important Bacteria

23

(2)

Normal Flora

25

(5)

Pathogenesis

30

(23)

Host Defenses

53

(9)

Laboratory Diagnosis

62

(7)

Antimicrobial Drugs: Mechanism of Action

69

(16)

Antimicrobial Drugs: Resistance

85

(9)

Bacterial Vaccines

94

(4)

Sterilization & Disinfection

98

(4)

II. CLINICAL BACTERIOLOGY

102

(90)

Overview of the Major Pathogens & Introduction to Anaerobic Bacteria

102

(4)

Gram-Positive Cocci

106

(13)

Gram-Negative Cocci

119

(5)

Gram-Positive Rods

124

(9)

Gram-Negative Rods Related to the Enteric Tract

133

(19)

Gram-Negative Rods Related to the Respiratory Tract

152

(5)

Gram-Negative Rods Related to Animal Sources (Zoonotic Organisms)

157

(4)

Mycobacteria

161

(8)

Actinomycetes

169

(2)

Mycoplasmas

171

(2)

Spirochetes

173

(6)

Chlamydiae

179

(3)

Rickettsiae

182

(4)

Minor Bacterial Pathogens

186

(6)

III. BASIC VIROLOGY

192

(56)

Structure

193

(6)

Replication

199

(13)

Genetics & Gene Therapy

212

(4)

Classification of Medically Important Viruses

216

(5)

Pathogenesis

221

(7)

Host Defenses

228

(5)

Laboratory Diagnosis

233

(3)

Antiviral Drugs

236

(8)

Viral Vaccines

244

(4)

IV. CLINICAL VIROLOGY

248

(86)

DNA Enveloped Viruses

251

(11)

DNA Nonenveloped Viruses

262

(4)

RNA Enveloped Viruses

266

(17)

RNA Nonenveloped Viruses

283

(8)

Hepatitis Viruses

291

(10)

Arboviruses

301

(5)

Tumor Viruses

306

(10)

Slow Viruses & Prions

316

(5)

Human Immunodeficiency Virus

321

(9)

Minor Viral Pathogens

330

(4)

V. MYCOLOGY

334

(16)

Basic Mycology

334

(5)

Cutaneous & Subcutaneous Mycoses

339

(2)

Systemic Mycoses

341

(5)

Opportunistic Mycoses

346

(4)

VI. PARASITOLOGY

350

(41)

Intestinal & Urogenital Protozoa

351

(6)

Blood & Tissue Protozoa

357

(10)

Minor Protozoan Pathogens

367

(2)

Cestodes

369

(6)

Trematodes

375

(5)

Nematodes

380

(11)

VII. IMMUNOLOGY

391

(86)

Immunity

391

(10)

Cellular Basis of the Immune Response

401

(20)

Antibodies

421

(9)

Humoral Immunity

430

(2)

Cell-Mediated Immunity

432

(2)

Major Histocompatibility Complex & Transplantation

434

(5)

Complement

439

(4)

Antigen-Antibody Reactions in the Laboratory

443

(10)

Hypersensitivity (Allergy)

453

(8)

Tolerance & Autoimmune Disease

461

(8)

Tumor Immunity

469

(2)

Immunodeficiency

471

(6)

VIII. BRIEF SUMMARIES OF MEDICALLY IMPORTANT ORGANISMS

477

(38)

Summaries of Medically Important Bacteria

477

(16)

Summaries of Medically Important Viruses

493

(10)

Summaries of Medically Important Fungi

503

(3)

Summaries of Medically Important Parasites

506

(9)

IX. CLINICAL CASES

515

(10)

X. PEARLS FOR THE USMLE

525

(7)

XI. USMLE (NATIONAL BOARD) PRACTICE QUESTIONS

532

(51)

Basic Bacteriology

532

(5)

Clinical Bacteriology

537

(8)

Basic Virology

545

(4)

Clinical Virology

549

(7)

Mycology

556

(3)

Parasitology

559

(3)

Immunology

562

(10)

Extended Matching Questions

572

(2)

Clinical Case Questions

574

(9)

XII. USMLE (NATIONAL BOARD) PRACTICE EXAMINATION

583

(12)

Index

595

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Review Of Medical Microbiology and Immunology

Summary

Author Biography

Table of Contents

Supplemental Materials