Addresses the challenges faced in the design, development, and scale-up of large-scale chromatographic processes. Offers fundamental analysis of the underlying physiochemical principles.
Preface
v
Contributors
xi
Part I Methods and Approaches
An Overview of Scale-Up in Preparative Chromatography
1
(32)
Anurag S. Rathore
Ajoy Velayudhan
Interaction of Mass Transfer and Fluid Mechanics
33
(44)
Edwin N. Lightfoot
John S. Moscariello
Mark A. Teeters
Thatcher W. Root
Optimization of Preparative Separations
77
(46)
Attila Felinger
Engineering Aspects of Ion-Exchange Chromatography
123
(50)
Peter Watler
Shuichi Yamamoto
Oliver Kaltenbrunner
Daphne N. Feng
A Simple Approach to Design and Control of Simulated Moving Bed Chromatographs
173
(30)
Firoz D. Antia
Large-Scale Ion-Exchange Chromatography: A Comparison of Different Column Formats
203
(28)
Peter R. Levison
Part II Case Studies
Development and Operation of a Cation-Exchange Chromatography Process for Large-Scale Purification of a Recombinant Antibody Fragment
231
(20)
Robert L. Fahrner
Stacey Y. Ma
Michael G. Mulkerrin
Nancy S. Bjork
Gregory S. Blank
Case Study: Capacity Challenges in Chromatography-Based Purification of Plasmid DNA
251
(22)
Sangeetha L. Sagar
Ying G. Chau
Matthew P. Watson
Ann L. Lee
Case Study: Purification of an IgG1 Monoclonal Antibody
273
(16)
Paul K. Ng
Case Study: Normal Phase Purification of Kilogram Quantities of a Synthetic Pharmaceutical Intermediate
289
(14)
Larry Miller
James Murphy
Case Study: Development of Chromatographic Separation to Remove Hydrophobic Impurities in Altrafloxacin
303
(14)
Sam Guhan
Mark Guinn
Case Study: Process Development of Chromatography Steps for Purification of a Recombinant E. coli Expressed Protein
317
(22)
Anurag S. Rathore
Index
339
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