Transforming Growth Factor-B in Cancer Therapy

, by Jokowlew, Sonia B., Ph.D.; Sporn, Michael B.

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ISBN: 9781588297143 | 1588297144
Cover: Hardcover
Copyright: 3/30/2008

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Transforming Growth Factor-[beta] in Cancer Therapy, Volumes I and II, provide a compendium of findings about the role of transforming growth factor-[beta] (TGF-[beta]) in basic and clinical biology and cancer treatment and therapy. The first volume, Basic and Clinical Biology, is divided into three parts. Part I presents basic concepts of TGF-[beta] signaling in normal physiology and cancer pathobiology. Part II investigates TGF-[beta] superfamily members in normal and tumor biology. Part III details TGF-[beta] in inflammation and fibrosis.

In Memoriam	p. v
Foreword	p. vii
Preface	p. ix
Biography	p. xiii
Contributors	p. xix
Basic Concepts of TGF-[beta] Signaling in Normal Physiology and Cancer Pathobiology
Component Hardware for Transforming Growth Factor-[beta] Signal Transduction: TGF-[beta] Ligands, TGF-[beta] Receptors, and Smads	p. 3
TGF-[beta] Signaling in Homeostasis and Cancer	p. 23
TGF-[beta] Availability: Latent TGF-[beta] and Latent TGF-[beta] Binding Proteins	p. 37
Biological Functions of Latent TGF-[beta]-Binding Proteins and Activation of TGF-[beta]	p. 57
Regulators of Smad2/3 Transcription and Phosphorylation	p. 77
Interaction of Smad4 and Embryonic Liver Fodrin-[beta]-spectrin in Hyperplasia, Neoplasia, and Tumor Suppression	p. 91
Regulation of Smad Activity by Phosphorylation	p. 105
Nuclear Targeting of TGF-[beta]-Activated Smads in Normal and Tumor Biology	p. 125
Ski, SnoN, and Akt as Negative Regulators of Smad Activity: Balancing Cell Death and Cell Survival	p. 139
Transforming Growth Factor-[beta] in Cancer Therapy: Smurfs in TGF-[beta] Signaling and Regulation of Bone Homeostasis and Cancer	p. 155
Involvement of km23 Dynein Light Chains in TGF [beta] Signaling	p. 169
TGF-[beta] Signaling in Fibroblastic Cells and Oncogenesis	p. 185
Mechanisms of TGF-[beta]-Induced Apoptosis in Cancer Cells	p. 199
Mechanisms of Cell Cycle Regulation by TGF-[beta] Disabled in Cancer	p. 213
Transforming Growth Factor-[beta] in Cancer Therapy: Proteasome in the Control of TGF-[beta] Signaling During Development and Cancer	p. 243
TGF-[beta] and Smad Signaling in Transcriptome Reprogramming During EMT	p. 259
Functional Interactions Between MMPs and TGF-[beta] in Normal and Tumor Tissue	p. 275
Cooperation Between TGF-[beta] and Wnt Pathway Components in Regulating Mesenchymal Stem Cell Function	p. 293
Interaction of Oncogenic Ras and TGF[beta]1 Signaling in Cancer: Lessons From the Multistage Skin Carcinogenesis Model	p. 305
TGF-[beta] Superfamily Members in Normal and Tumor Biology
Proteomics Analysis of TGF[beta] Superfamily Members	p. 319
Mullerian Inhibiting Substance: A Potential Nontoxic, Naturally Occurring Therapeutic Agent for Certain Human Cancers	p. 333
Activins, Inhibins, and Bone Morphogenetic Proteins as Modulators and Biomarkers of Prostate Cancer Progression	p. 355
Bone Morphogenic Proteins and Angiogenesis in Developing Tumors	p. 373
Histone Methyltransferase and Smad Interactions in BMP Signaling	p. 383
Endoglin (CD105): A Strong Candidate for Immunologic Targeting of Tumor Neovasculature in Human Malignancies	p. 395
Activins and Inhibins in Cancer Progression	p. 411
Bone Morphogenetic Proteins/Growth Differentiation Factors and Smad Activation in Ovarian Granulosa Cells and Carcinoma	p. 425
Regulation of the Transforming Growth Factor-[beta] Superfamily by Betaglycan	p. 451
Uterine Sensitization Associated Gene-1: A Bone Morphogenetic Protein Antagonist with a Role in Kidney	p. 463
Role of Betaig-h3 Gene in Carcinogenesis	p. 475
Activins and the Liver	p. 483
Myostatin Signaling in Normal and Tumor Cells	p. 509
TGF-[beta] in Inflammation and Fibrosis
Triterpenoids, Vitamin D, and TGF-[beta]/Smad Signaling in Inflammation and Cancer	p. 525
Thrombospondin-Dependent Activation of Latent TGF-[beta] in Fibrosis and Disease	p. 549
TGF-[beta] in Pulmonary Fibrosis	p. 569
The Role of TGF-[beta] in Bleomycin Induced Pulmonary Fibrosis	p. 581
Smads in the Fibrotic Response: Findings in the Smad3 Knockout Mouse	p. 595
TGF-[beta] Signaling in Renal Fibrosis and Inflammation: Gene Therapy Using Ultrasound-Microbubble-Mediated Inducible Smad7	p. 609
Transforming Growth Factor-[beta] Peptide Signaling in Pulmonary Development, Bronchopulmonary Dysplasia, Fibrosis, and Emphysema	p. 621
The Role of TGF-[beta] in Radiation and Chemotherapy Induced Pulmonary Fibrosis: Inhibition of TGF-[beta] as a Novel Therapeutic Strategy	p. 629
Negative Regulation of the TGF-[beta] Family Signal Pathway by Inhibitory Smads and Their Involvement in Cancer and Fibrosis	p. 649
TGF-[beta]-Related Antifibrotic Strategies in the Eye	p. 663
Transforming Growth Factor-[beta] in Cutaneous Tissue Repair	p. 675
Topical Application of TGF-[beta]1 Peptide Inhibitors for the Therapy of Skin Fibrosis	p. 693
Overexpressed Truncated TGF-[beta] Type II Receptor Inhibits Fibrotic Behavior of Keloid Fibroblasts In Vitro and Experimental Scar Formation In Vivo	p. 703
Index	p. 723
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Transforming Growth Factor-B in Cancer Therapy

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