Molecular and Cellular Gerontology

, by Toussaint, Olivier; Osiewaz, Heinz D.; Lithgow, Gordon J.; Brack, Christine

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ISBN: 9781573312714 | 1573312711
Cover: Hardcover
Copyright: 7/1/2000

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Supplemental Materials

Preface

Christine Brack

Gordon J. Lithgow

Heinz D. Osiewacz

Olivier Toussaint

Some New Directions for Research on the Biology of Aging

(13)

George M. Martin

Molecular Gerontology. Bridging the Simple and the Complex

(7)

Thomas B.L. Kirkwood

Metabolic Control and Gene Dysregulation in Yeast Aging

(10)

S. Michal Jazwinski

Mitochondrial Oxidative Stress and Aging in the Filamentous Fungus Podospora anserina

(9)

Heinz D. Osiewacz

Corina Borghouts

Molecular Genetic Mechanisms of Life Span Manipulation in Caenorhabditis elegans

(10)

Shin Murakami

Patricia M. Tedesco

James R. Cypser

Thomas E. Johnson

Genetics of Human Aging. The Search for Genes Contributing to Human Longevity and Diseases of the Old

(14)

P. Eline Slagboom

Bastiaan T. Heijmans

Marian Beekman

Rudi G.J. Westendorp

Ingrid Meulenbelt

Genetics of Survival

(7)

Francois Schachter

Melanin Accumulation Accelerates Melanocyte Senescence by a Mechanism Involving p16INK4a/CDK4/pRB and E2F1

(14)

Debdutta Bandyopadhyay

Estela E. Medrano

Stress-Induced Premature Senescence. Essence of Life, Evolution, Stress, and Aging

(14)

Oliver Toussaint

Patrick Dumont

Jean-Francois Dierick

Thierry Pascal

Christophe Frippiat

Florence Chainiaux

Francis Sluse

Francois Eliaers

Jose Remacle

Role of Oxidative Stress in Telomere Length Regulation and Replicative Senescence

(12)

Thomas von Zglinicki

Replicative Senescence and Oxidant-Induced Premature Senescence. Beyond the Control of Cell Cycle Checkpoints

111

(15)

Qin M. Chen

Poly (ADP-Ribosyl)ation, Genomic Instability, and Longevity

126

(7)

Alexander Burkle

Aging and Longevity. A Paradigm of Complementation between Homeostatic Mechanisms and Genetic Control?

133

(10)

Chariklia Petropoulou

Niki Chondrogianni

Davina Simoes

Georgia Agiostratidou

Natalia Drosopoulos

Violetta Kotsota

Efstathios S. Gonos

Protein Degradation by the Proteasome and Its Implications in Aging

143

(12)

Bertrand Friguet

Anne-Laure Bulteau

Niki Chondrogianni

Mariangela Conconi

Isabelle Petropoulos

Fibroblast Responses to Exogenous and Autocrine Growth Factors Relevant to Tissue Repair. The Effect of Aging

155

(12)

Dimitris Kletsas

Harris Pratsinis

Irene Zervolea

Panagiotis Handris

Eleni Sevaslidou

Enzo Ottaviani

Dimitri Stathakos

The Werner Syndrome. A Model for the Study of Human Aging

167

(13)

Jan O. Nehlin

Gunhild Lange Skovgaard

Vilhelm A. Bohr

Calorie Restriction and Age-Related Oxidative Stress

180

(19)

B.J. Merry

Role of Mitochondrial DNA Mutations in Disease and Aging

199

(9)

D.A. Cottrell

E.L. Blakely

G.M. Borthwick

M.A. Johnson

G.A. Taylor

E.J. Brierley

P. Ince

D.M. Turnbull

Inherited Variability of the Mitochondrial Genome and Successful Aging in Humans

208

(11)

G. De Benedictis

G. Carrieri

O. Varcasia

M. Bonafe

C. Franceschi

Mitochondrial Oxidative Stress. Physiologic Consequences and Potential for a Role in Aging

219

(7)

Simon Melov

Tissue Mitochondrial DNA Changes. A Stochastic System

226

(18)

George Kopsidas

Sergey A. Kovalenko

Damien R. Heffernan

Natalia Yarovaya

Ludmilla Kramarova

Diane Stojanovski

Judy Borg

Monirul Islam

Aphrodite Caragounis

Anthony W. Linnane

Inflamm-aging. An Evolutionary Perspective on Immunosenescence

244

(11)

Claudio Franceschi

Massimiliano Bonafe

Silvana Valensin

Fabiola Olivieri

Maria De Luca

Enzo Ottaviani

Giovanna de Benedictis

The CA1 Region of the Human Hippocampus Is a Hot Spot in Alzheimer's Disease

255

(5)

M.J. West

C.H. Kawas

L.J. Martin

J.C. Troncoso

Transgenic Mouse Models of Alzheimer's Disease

260

(7)

Klaus D. Bornemann

Matthias Staufenbiel

Molecular Misreading. A New Type of Transcript Mutation in Gerontology

267

(15)

Fred W. van Leeuwen

David F. Fischer

Rob Benne

Elly M. Hol

Biogerontology: The Next Step

282

(9)

Suresh I.S. Rattan

Nuclear-Mitochondrial Interactions Involved in Aging in Podospora anserina

291

(4)

Corina Borghouts

Heinz D. Osiewacz

Inherited Frailty. ApoE Alleles Determine Survival after a Diagnosis of Heart Disease or Stroke at Ages 85+

295

(4)

E.H. Corder

H. Basun

L. Fratiglioni

Z. Guo

L. Lannfelt

M. Viitanen

L.S. Corder

K.G. Manton

B. Winblad

MtDNA Deletions in Aging and in Nonmitochondrial Pathology

299

(3)

A. Cormio

A.M.S. Lezza

J. Vecchiet

G. Felzani

L. Marangi

F.W. Guglielmi

A. Francavilla

P. Cantatore

M.N. Gadaleta

Transcriptome and Proteome Analysis in Human Senescent Fibroblasts and Fibroblasts Undergoing Premature Senescence Induced by Repeated Sublethal Stresses

302

(4)

Jean-Francois Dierick

Thierry Pascal

Florence Chainiaux

Francois Eliaers

Jose Remacle

Peter Mose Larsen

Peter Roepstorff

Olivier Toussaint

Human Diploid Fibroblasts Display a Decreased Level of c-fos mRNA at 72 Hours after Exposure to Sublethal H2O2 Stress

306

(4)

Patrick Dumont

Maggi Burton

Qin M. Chen

Christophe Frippiat

Thierry Pascal

Jean-Francois Dierick

Francois Eliaers

Florence Chainiaux

Jose Remacle

Olivier Toussaint

Replicative Senescence of Interleukin-2-Dependent Human T Lymphocytes. Flow Cytometric Characteristics of Phenotype Changes

310

(5)

Ewa Jaruga

Janusz Skierski

Ewa Radzieszewska

Ewa Sikora

Age-Related Changes in Irradiation-Induced Apoptosis and Expression of p21 and p53 in Crypt Stem Cells of Murine Intestine

315

(4)

Kareen Martin

Christopher S. Potten

Thomas B.L. Kirkwood

Testing Evolutionary Theories of Aging

319

(2)

Gawain McColl

Nicole L. Jenkins

David W. Walker

Gordon J. Lithgow

A Novel in Vitro Model of Conditionally Immortalized Human Vascular Smooth Muscle Cells. A Tool for Aging Studies

321

(3)

Harris Pratsinis

Catherine Demoliou-Mason

Alun Hughes

Dimitris Kletsas

Using Stress Resistance to Isolate Novel Longevity Mutations in Caenorhabditis elegans

324

(3)

James N. Sampayo

Nicole L. Jenkins

Gordon J. Lithgow

Telomere Length As a Marker of Oxidative Stress in Primary Human Fibroblast Cultures

327

(4)

Violeta Serra

Tilman Grune

Nicolle Sitte

Gabriele Saretzki

Thomas von Zglinicki

Programmed Cell Death and Senescence in Skeletal Muscle Stem Cells

331

(5)

Kathryn Woods

Anna Marrone

Janet Smith

Study of the H1 Linker Histone Variant, H1o, during the in Vitro Aging of Human Diploid Fibroblasts

336

(5)

D.S. Tsapali

K.E. Sekeri-Pataryas

T.G. Sourlingas

Aging-Related Muscle Dysfunction. Failure of Adaptation to Oxidative Stress?

341

(3)

S. Spiers

F. McArdle

M.J. Jackson

A Theoretical Model for ``in machina'' Experiments on Immunosenescence

344

(5)

Silvana Valensin

Gianni Di Caro

Index of Contributors

349

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Molecular and Cellular Gerontology

Table of Contents

Supplemental Materials