Evolution of Virulence in Eukaryotic Microbes

"Evolution of Virulence in Eukaryotic Microbes" addresses new developments in defining the molecular basis of virulence in eukaryotic pathogens. By examining how pathogenic determinants have evolved in concert with their hosts, often overcoming innate and adaptive immune mechanisms, "Evolution of Virulence" takes a fresh look at the selective processes that have shaped their evolution. Introductory chapters ground the reader in principal evolutionary themes such as phylogenetics and genetic exchange, building a basis of knowledge for later chapters covering advances in genetic tools, how pathogens exchange genetic material in nature, and the common themes of evoluationary adaptation that lead to disease in different hosts.

Dr. David Sibley, PhD, is a faculty member at the Washington University School of Medicine, where he teaches graduate courses in microbiology and has served on the steering committee for the Molecular Microbiology program for the past 10 years. In addition to authoring over 150 publications,?Dr. Sibley is an associate editor for PLoS Pathogens, edits reviews for Cellular Microbiology, and serves on the board of reviewing editors for Science.

Dr. Barbara Howlett, PhD, is a Professor in the School of Botany at the University of Melbourne, specializing in fungal diseases of plants. She serves in an editorial capacity for PLoS Pathogens, Eukaryotic Cell, and the European Journal of Plant Pathology.

Dr. Joseph Heitman, MD, PhD is currently Chair of the Dept of Molecular Genetics and Microbiology at Duke University. Dr. Heitman has co-authored four other books on the topics of eukayrotic function and pathogenesis, and serves as an editor for numerous?publication includingEukaryotic Cell, Virulence, and the Journal of Molecular Medicine.

Preface	p. ix
Acknowledgments	p. xi
Contributors	p. xiii
General Overviews	p. 1
Population Genetics and Parasite Diversity	p. 3
Evolution of Meiosis, Recombination, and Sexual Reproduction in Eukaryotic Microbes	p. 17
Phylogenomic Analysis	p. 44
Phylogenetics and Evolution of Virulence in the Kingdom Fungi	p. 70
Population Genetics and Evolutionary Approaches	p. 91
Malaria: Host Range, Diversity, and Speciation	p. 93
From Population Genomics to Elucidated Traits in Plasmodium Falciparum	p. 111
Selective Sweeps in Human Malaria Parasites	p. 124
Evolution of Drug Resistance in Fungi	p. 143
Discovery of Extant Sexual Cycles in Human Pathogenic Fungi and Their Roles in the Generation of Diversity and Virulence	p. 168
Worldwide Migrations, Host Shifts, and Reemergence of Phytophthora Infestans, the Plant Destroyer	p. 192
Experimental and Natural Evolution of the Cryptococcus Neoformans and Cryptococcus Gattii Species Complex	p. 208
Population Genetics, Diversity, and Spread of Virulence in Toxoplasma Gondii	p. 231
Forward and Reverse Genetic Systems for Defining Virulence	p. 247
Genetic Crosses in Plasmodium Falciparum: Analysis of Drug Resistance	p. 249
Genetic Mapping of Virulence in Rodent Malarias	p. 269
Genetic Mapping of Acute Virulence in Toxoplasma Gondii	p. 285
Virulence in African Trypanosomes: Genetic and Molecular Approaches	p. 307
The Evolution of Antigenic Variation in African Trypanosomes	p. 324
Antigenic Variation, Adherence, and Virulence in Malaria	p. 338
Invasion Ligand Diversity and Pathogenesis in Blood-Stage Malaria	p. 362
Comparative "Omics" Approaches to Defining Virulence	p. 385
Evolution of Virulence in Oomycete Plant Pathogens	p. 387
Evolution and Genomics of the Pathogenic Candida Species Complex	p. 404
Evolution of Entamoeba Histolytica Virulence	p. 422
Sex and Virulence in Basidiomycete Pathogens	p. 437
Emergence of the Chytrid Fungus Batrachochytrium Dendrobatidis and Global Amphibian Declines	p. 461
Impact of Horizontal Gene Transfer on Virulence of Fungal Pathogens of Plants	p. 473
Evolution of Plant Pathogenicity in Fusarium Species	p. 485
Genetic, Genomic, and Molecular Approaches to Define Virulence of Aspergillus Fumigatus	p. 501
Ctyptosporidium: Comparative Genomics and Pathogenesis	p. 518
Index	p. 545
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Evolution of Virulence in Eukaryotic Microbes

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