Cytotoxins and Immunotoxins for Cancer

This book presents state-of-the-art information on various cytotoxins and immunotoxins in a single resoruce. The editors bring together leading researchers to summarize their work and discuss clinical trial data concerning some of the most widely studied tumors. The book describes Pseudomonas exotoxin (PE)-based immunotoxins and presents the latest results from clinical trials for the treatment of recurrent glioblastoma and other human cancers. It reviews the role of ricin-based immunotoxins for the treatment of lymphoma, explores several DT-based immunotoxins, and details the preclinical and clinical development of the first FDA-approved cytotoxin.

Preface: An Overview of Immunotoxins and Cytotoxins in Clinical Trials
Pseudomonas Exotoxin (Pe)-Based Immunotoxins/Cytotoxins
Targeting of Pseudomonas Exotoxin-based Immunotoxins to Hematologic Malignancies
Interleukin-4-targeted Cytotoxin for Recurrent Glioblastoma Therapy
Interleukin-13 Receptors and Development of IL-13-Pseudomonas Exotoxin for Human Cancer Therapy
Ricin-Based Immunotoxins/Cytotoxins
Ricin Immunotoxins in Lymphomas
Diphtheria Toxin
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Cytotoxins and Immunotoxins for Cancer Therapy : Clinical Applications

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