Synaptic Plasticity: Basic Mechanisms to Clinical Applications

Note: Supplemental materials are not guaranteed with Rental or Used book purchases.

ISBN: 9780824759001 | 0824759001
Cover: Hardcover
Copyright: 4/12/2005

Rent

(Recommended)

$155.74

Term

Due

Price

Semester

Dec 13

$173.04

Quarter

Aug 30

$164.39

Short Term

Jul 26

$155.74

*This item is part of an exclusive publisher rental program and requires an additional convenience fee. This fee will be reflected in the shopping cart.
Buy Used

Usually Ships in 2-4 Business Days

$176.40
Buy New

Usually Ships in 3-5 Business Days

$236.41
eBook

Available Instantly

Online: 180 Days

Downloadable: 180 Days

$123.75

This reference provides a clear understanding of the basic mechanisms of synaptic transmission and information processing and illustrates potential clinical applications for the recovery of lost function as a result of gene defects, injury, or disease-relating the most recent advances in the design of new therapeutics, the treatment of neurological disease and age-related loss of cognitive function, rehabilitation therapy, and neural engineering and computation.

Preface

iii

Contributors

xvii

Memory: From Molecular Mechanisms to Clinical Applications

(24)

Michel Baudry

Introduction

(1)

LTP: A Cellular Mechanism for Learning and Memory

(7)

Current Hypotheses for LTP/LTD Mechanisms

(4)

Ampakines, LTP, and Memory

(2)

Clinical Trials of Ampakines

(1)

Conclusions

(9)

References

(9)

Synaptogenesis as a Correlate of Activity-Induced Plasticity

(14)

Irina Nikonenko

Pascal Jourdain

Bemadett Boda

Dominique Muller

Introduction

(1)

Changes in Spine Dynamics with Activity

(1)

Modulation of Spine Morphology by Activity

(2)

Evidence for Activity-Induced Synaptogenesis

(2)

Postsynaptic Mechanisms Controlling Activity-Induced Synaptogenesis

(1)

Activity-Induced Remodeling of Presynaptic Terminals

(1)

Conclusions

(7)

References

(6)

Volume Transmission: Role in the Carry-Over Functional Effect in Tactile Vestibular Substitution?

(14)

Paul Bach-y-Rita

Volume Transmission

(3)

The History of Volume Transmission

(2)

Computational Neuroscience VT Studies

(3)

Carry-Over Functional Effect in Tactile Vestibular Substitution?

(6)

References

(5)

Lysosomal Dysfunction in Brain Aging and Neurodegeneration: Roles in Trophic Signaling and Neuroinflammation

(22)

Xiaoning Bi

Lysosomal Dysfunction and Brain Aging

(4)

Lysosomal Dysfunction and Trophic Endosomal Signaling

(1)

Lysosomal Dysfunction and Neuroinflammation

(4)

Roles of Lysosomal Dysfunction in Brain Aging and Neurodegeneration: A Hypothesis

(13)

References

(11)

Axonal Sprouting in the Adult Brain: Mechanisms of Lesion-Specific Sprouting of the Corticostriatal Pathway in Adult Rats

(14)

Marie-Francoise Chesselet

S. Thomas Carmichael

Marc Shomer

Dorothy Harris

Veronique Riban

Introduction

(1)

Lesion-Specific Axonal Sprouting of the Corticostriatal Pathway

(4)

The Role of Electrophysiological Activity in Axonal Sprouting in the Adult Brain

(5)

Myelin-Associated Proteins and Axonal Sprouting in the Adult Brain

(1)

Conclusion

(4)

References

(3)

Behavioral Implications for the Activity Dependent Regulation of Neurotrophins

(42)

Fernando Gomez-Pinilla

Shoshanna Vaynman

Introduction

(1)

Cell Biology of NTs

(5)

Neurotrophins and Neural Activity

(6)

Neurotrophins and Learning and Memory

101

(6)

Neurotrophins and Behavior and Lifestyle: Experience-Dependent Plasticity

107

(11)

Conclusions and Research Demands

118

(13)

References

118

(13)

Estrogen Therapy for Prevention of Alzheimer's Disease But Not for Rehabilitation Following Onset of Disease: The Healthy Cell Bias of Estrogen Action

131

(28)

Roberta Diaz Brinton

Introduction

131

(1)

Alzheimer's Disease: A Potential Health Crisis

132

(1)

Hormone Replacement Therapy (HRT) and Risk of Developing AD: Importance of the Time of Onset and the Type of HRT

133

(7)

The Role of Estrogen in Cognitive Functions

140

(6)

How Might Estrogen-Replacement Therapy Reduce the Risk of AD?

146

(3)

Speculations on When to Intervene with Estrogen-Replacement Therapy

149

(2)

Summary

151

(8)

References

152

(7)

The Use of PET to Evaluate Neural Plasticity and Repair in Rodent Brain

159

(16)

Harley I. Kornblum

Keith J. Tatsukawa

S. Thomas Carmichael

Simon R. Cherry

Introduction

159

(1)

Principles of PET

160

(3)

Dedicated Lab Animal PET Scanners

163

(1)

Studies of Glucose Utilization and Neuroplasticity

164

(4)

Other Potential Applications of PET in Neuroplasticity

168

(1)

Current Limitations for the Use of PET in Studies of Rodent CNS Plasticity

169

(2)

Comparison of PET to Other In Vivo Functional Imaging Modalities

171

(4)

References

173

(2)

Use of Estrogens as Neuroprotectants in Stroke and Alzheimer's Disease

175

(14)

James W. Simpkins

Shao-Hua Yang

Yi Wen

Introduction

175

(1)

Estrogen Physiology and Pharmacology

176

(1)

Current Clinical Uses of Estrogens

176

(1)

Evidence for Efficacy of Estrogens and Estrogen Analogs in Stroke Neuroprotection

177

(3)

Transient Cerebral Ischemia as a Model for Alzheimer's Disease Neuropathology

180

(3)

Need for Further Studies

183

(6)

References

183

(6)

Cell Death After Spinal Cord Injury: Basic Mechanisms and Potential Therapeutic Approaches to Promote Functional Recovery

189

(20)

Steven S. Schreiber

Apoptosis vs. Necrosis

190

(1)

Molecular and Cellular Mechanisms of Apoptosis

191

(4)

Evidence for Apoptosis After SCI

195

(3)

Prevention of Apoptosis After SCI

198

(2)

Conclusion

200

(9)

References

200

(9)

Motor Rehabilitation After Stroke: Novel Physical Treatment Strategies

209

(20)

Stefan Hesse

Cordula Werner

Introduction

209

(1)

General Principles of Physical Therapy

210

(1)

Special Aspects of Upper Limb Rehabilitation

210

(8)

Special Aspects of Gait Rehabilitation

218

(6)

Summary

224

(5)

References

224

(5)

Neural Bases for Rehabilitation After Stroke

229

(26)

Randolph J. Nudo

Ann M. Stowe

Ines Eisner-Janowicz

Numa Dancause

Animal Models of Stroke and Rehabilitation

230

(1)

Effects of Motor Injury on Behavioral Function: Recovery and Compensation

231

(2)

Neurophysiological Consequences of Motor Cortex Injury

233

(5)

Influence of Postinjury Motor Experience on Reorganization of Motor Maps

238

(1)

Anatomical Consequences Following Motor Cortex Injury

239

(2)

Influence of Postinjury Motor Experience on Neuroanatomical Plasticity

241

(2)

New Approaches to Maximize Neuroplasticity and Recovery After Stroke

243

(2)

Summary

245

(10)

References

245

(10)

Plasticity of Language Networks

255

(16)

Cynthia K. Thompson

Neuroimaging Studies

256

(4)

Factors Related to Neuroplastic Processes

260

(7)

Conclusion

267

(4)

References

267

(4)

Locomotor Training-Induced Plasticity

271

(10)

Bruce H. Dobkin

Introduction

271

(1)

The Distributed Locomotor System

271

(4)

Interventions to Drive Activity-Dependent Plasticity

275

(1)

Summary

276

(5)

References

277

(4)

Constraint-Induced Therapy for Functional Recovery After Brain Injury: Unraveling the Key Ingredients and Mechanisms

281

(48)

C. J. Winstein

M. G. Prettyman

Introduction

281

(3)

Essentials of Constraint-Induced Therapy: What is the Evidence?

284

(26)

Two Complementary Mechanisms Underlying CI Therapy: What is the Evidence?

310

(19)

References

317

(12)

Stem Cell Grafting and Spinal Cord Injury

329

(32)

Richard L. Benton

Gaby U. Enzmann

Scott R. Whittemore

Introduction

329

(1)

Neural Stem Cell Transplantation in the Spinal Cord

330

(12)

Immortalized Cell Transplantation in the Spinal Cord

342

(5)

Bone Marrow and Stromal Stem Cell Transplantation in the Spinal Cord

347

(4)

Conclusions

351

(10)

References

351

(10)

Stem Cells and Huntington's Disease

361

(34)

N. Popovic

A. Petersen

J.-Y. Li

P. Brundin

Features of Huntington's Disease

361

(3)

Symptoms of HD

364

(1)

Strategies in the Treatment of HD

365

(7)

Striatal Neural Transplantation in Nonhuman Primates

372

(2)

Clinical Transplantation Trials in HD

374

(4)

Risk Factors of Neural Transplantation

378

(1)

Neurogenesis in HD

378

(1)

Conclusion

379

(16)

References

381

(14)

Plasticity, Cell Transplantation, and Brain Repair

395

(28)

Mate D. Dobrossy

Stephen B. Dunnett

Introduction

395

(1)

Cell Transplantation and Plasticity

396

(3)

Enhancing Graft Function

399

(5)

The Influence of Behavioral Experience and Training on Graft Function

404

(6)

The Choice of Cells

410

(2)

Conclusion: Plasticity and the Clinical Application of Cell Replacement Therapy

412

(11)

References

413

(10)

Brain-Implantable Biomimetic Electronics as Neural Prostheses to Restore Lost Cognitive Function

423

(36)

Theodore W. Berger

Ashish Ahuja

Patrick Nasiatka

Spiros H. Courellis

Gopal Erinjippurath

Ghassan Gholmieh

John J. Granacki

Min Chi Hsaio

Jeffrey LaCoss

Vijayaraghavan Srinivasan

Vasilis Z. Marmarelis

Dong Song

Armand R. Tanguay, Jr.

Jack Wills

Introduction

424

(1)

The System: Hippocampus

425

(2)

General Strategy and System Requirements

427

(2)

Proof-of-Concept: Replacement of the CA3 Region of the Hippocampal Slice with a Biomimetic Device

429

(1)

Experimental Characterization of Nonlinear Properties of the Hippocampal Trisynaptic Pathway

430

(2)

Nonlinear Dynamic Modeling of CA3 Input/Output Properties

432

(7)

Microcircuitry Implementation of the CA3 Input/Output Model

439

(8)

Conformal, Multisite Electrode Array Interface

447

(4)

System Integration: Current Status of the Hippocampal Slice Prosthetic

451

(8)

References

453

(6)

Behaviorally Relevant Neural Codes in Hippocampal Ensembles: Detection on Single Trials

459

(18)

John D. Simeral

Robert E. Hampson

Sam A. Deadwyler

Introduction

459

(1)

Recording and Analysis Methods

460

(5)

Representation of Phase and Position

465

(6)

Detection and Dynamics of Representations

471

(6)

References

473

(4)

Recent Advances Toward Development of Practical Brain--Machine Interfaces

477

(26)

David J. Krupa

Brain--Machine Interfaces

477

(3)

Input BMIs

480

(4)

Output BMIs

484

(8)

Closed-Loop Input--Output BMIs

492

(3)

Conclusions

495

(8)

References

495

(8)

Index

503

Please wait while the item is added to your bag...

FREE SHIPPING

Amazon no longer offers textbook rentals. We do!

Synaptic Plasticity: Basic Mechanisms to Clinical Applications

Summary

Table of Contents

Supplemental Materials