Systems Biology in Drug Discovery and Development

This is the first comprehensive systems biology book to focus on its applications in drug discovery and development. Using real-world examples, the book shows how systems biology can be used to enhance pharmaceutical research and drug development. It highlights essential components of drug discovery like target identification and validation and complementary systems approaches like text-mining, large multi-context datasets and regression modeling. It also provides models for treatment personalization and methods for applying systems biology to pharmacokinetics, pharmacodynamics, and candidate biomarker indentification. Introducing key methods and technical approaches the book addresses the challenges currently facing the drug industry.

Daniel L. Young, Phd, is the Director of Computational Biosciences at Theranos Inc., where he leads the development of systems biology approaches to advances and entrance drug discovery and development and the optimal delivery of healthcare. He has written over twenty publications in the field of systems biology. Seth Michelson, PhD, is the Director of Nonclinical Biostatistics at Genomic Health, Inc. inventor or co-inventor for fourteen patient applications and one issued patient, and has contributed to over severity publications.