A Textbook of Modern Toxicology

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ISBN: 9780470462065 | 047046206X
Cover: Hardcover
Copyright: 6/21/2010

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Toxicology is a multi-faceted field that requires a keen analytical eye. A Textbook of Modern Toxicology is a unique resource that provides both students and practitioners with an insightful overview of this discipline. This Fourth Edition adds chapters on new approaches to toxicology along with end-of-chapter questions and a solutions manual for academic adopters. Continuing its legacy as a valuable learning tool, this expert text will find a prominent place on the bookshelf of anyone studying this science.

Introduction
Introduction
Definition and Scope
Relationship to Other Sciences
A Brief History of Toxicology
Dose-Response Relationships
Sources of Toxic Compounds
Movement of Toxicants in the Environment
Suggested Reading
Sample Questions
Introduction to Biochemical and Molecular Methods in Toxicology
Introduction
Cell Culture Techniques
Molecular Techniques
Immunochemical Techniques
Proteomics
Metabolomics
Bioinformatics
Summary and Conclusions
Suggested Reading
Sample Questions
Classes of Toxicants
Exposure Classes, Toxicants in Air, Water, Soil, Domestic and Occupational Settings
Air Pollutants
Water and Soil Pollutants
Occupational Toxicants
Suggested Reading
Sample Questions
Classes of Toxicants: Use Classes
Introduction
Metals
Agricultural Chemicals (Pesticides)
Food Additives and Contaminants
Toxins
Solvents
Therapeutic Drugs
Drugs of Abuse
Combustion Products
Cosmetics
Suggested Reading
Sample Questions
Toxicant Processing In Vivo
Absorption and Distribution of Toxicants
Introduction
Cell Membranes
Mechanisms of Transport
Physicochemical Properties Relevant to Diffusion
Routes of Absorption
Toxicant Distribution
Toxicokinetics
Suggested Reading
Sample Questions
Metabolism of Toxicants
Introduction
Phase I Reactions
Phase II Reactions
Suggested Reading
Sample Questions
Reactive Metabolites
Introduction
Activation Enzymes
Nature and Stability of Reactive Metabolites
Fate of Reactive Metabolites
Factors Affecting Toxicity of Reactive Metabolites
Reactive Oxygen Species
Examples of Activating Reactions
Summary and Conclusions
Suggested Reading
Sample Questions
Chemical and Physiological Influences on Xenobiotic Metabolism
Introduction
Nutritional Effects
Physiological Effects
Comparative and Genetic Effects
Chemical Effects
Environmental Effects
Summary and Conclusions
Suggested Reading
Sample Questions
Elimination of Toxicants
Introduction
Transport
Renal Elimination
Hepatic Elimination
Respiratory Elimination
Conclusion
Suggested Reading
Sample Questions
Toxic Action
Acute Toxicity
Introduction
Acute Exposure and Effect
Dose-Response Relationships
Non-Conventional Dose-Response Relationships
Alternative Methods
Mechanisms of Acute Toxicity
Suggested Reading
Sample Questions
Chemical Carcinogenesis
DNA Damage and Mutagenesis
General Aspects of Cancer
Human Cancer
Classes of Agents That Are Associated with Carcinogenesis
General Aspects of Chemical Carcinogenesis
Oncogenes
Tumor Suppressor Genes
Suggested Reading
Sample Questions
Teratogenesis
Introduction
Overview of Embryonic Development
Principles of Teratogenesis
Mechanisms of Teratogenesis
Future Considerations
Suggested Reading
Sample Questions
Organ Toxicity
Hepatotoxicity
Introduction
Susceptibility of the Liver
Types of Liver Injury
Mechanisms of Hepatotoxicity
Examples of Hepatotoxicants
Metabolic Activation of Hepatotoxicants
Suggested Reading
Sample Questions
Nephrotoxicity
Introduction
Factors Contributing to Nephrotoxicity
Examples of Nephrotoxicants
Summary
Suggested Reading
Sample Questions
Toxicology of the Nervous System
Introduction
The Nervous System
Toxicant Effects on the Nervous System
Neurotoxicity Testing
Summary
Suggested Reading
Sample Questions
Reproductive System
Introduction
The-Hypothalamic-Pituitary-Gonadal Axis
Male Reproductive Physiology
Disruption of Male Reproduction by Toxicants
Female Reproductive Physiology
Disruption of Female Reproduction by Toxicants
Summary
Suggested Reading
Sample Questions
Endocrine System
Introduction
Endocrine System
Endocrine Disruption
Incidents of Endocrine Toxicity
Conclusion
Suggested Reading
Sample Questions
Respiratory Toxicity
Introduction
Anatomy and Function of the Respiratory Tract
Toxicant-Induced Lung Injury, Remodeling and Repair
Occupational and Environmental Lung Diseases
Suggested Reading
Sample Questions
Immunotoxicity
Introduction
The Immune System
Immune Suppression
Classification of Immune-Mediated Injury (Hypersensitivity)
Effects of Chemicals on Allergic Disease
Other Issues: Autoimmunity, and the Developing Immune System
Suggested Reading
Sample Questions
Applied Toxicology
Toxicity Testing
Introduction
Experimental Administration of Toxicants
Chemical and Physical Properties
Exposure and Environmental Fate
In Vivo Tests
In Vitro and Other Short-Term Tests
Ecological Effects
Risk Analysis
The Future of Toxicity Testing
Suggested Reading
Sample Questions
Forensic and Clinical Toxicology
Introduction
Forensic Toxicology
Clinical Toxicology
Analytical Methods in Forensic and Clinical Toxicology
Suggested Reading
Sample Questions
Prevention of Toxicity
Introduction
Legislation and Regulation
Prevention in Different Environments
Education
Suggested Reading
Sample Questions
Human Health Risk Assessment
Introduction
Risk Assessment Methods
Non-Cancer Risk Assessment
Cancer Risk Assessment
PBPK Modeling
Suggested Reading
Sample Questions
Environmental Toxicology
Toxicant Analysis
Introduction
Environmental Sample Collection Methods
Analytical Techbiques
Quantification, Quality Assurance and Quality Control
Summary
Suggested Reading
Sample Questions
Basics of Environmental Toxicology
Introduction
Environmental Persistence
Bioaccumulation
Toxicity
Conclusion
Suggested Reading
Sample Questions
Transport and Fate of Toxicants in the Environment
Introduction
Sources of Toxicants to the Environment
Transport Processes
Equilibrium Partitioning
Transformation Processes
Environmental Fate Models
Suggested Reading
Sample Questions
Ecological Risk Assessment
Introduction
Formulating the Problem
Analyzing Exposure and Effects Information
Characterizing Risk
Managing Risk
Suggested Reading
Sample Questions
New Approaches in Toxicology
Perspectives on Informatics in Toxicology
Introduction
Transcriptomics
Annotation Resources
Genome Sequencing, Re-sequencing and Genotyping
Epigenomic Profiling
Computation Toxicology
Informatics Tools in Toxicology
Suggested Reading
Sample Questions
Future Considerations
Introduction
Risk Assessment
Risk Management
Risk Communication
In Vivo Toxicity
In Vitro Toxicity
Molecular and Biochemical Toxicology
Development of Selective Toxicants
Summary and Conclusions
Suggested Reading
Sample Questions
Glossary
Index
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A Textbook of Modern Toxicology

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