Therapeutic Oligonucleotides : Transcriptional and Translational Strategies for Silencing Gene Expression

, by Gewirtz, Alan M.; Cooley's Anemia Symposium 2005 Lake Buen; Vichinsky, Elliott P.

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ISBN: 9781573316088 | 1573316083
Cover: Hardcover
Copyright: 1/1/2006

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Foreword

Cliff Lane

Foreword: Looking to the Future

Paul Zamecnik

Introduction

xiii

Y. S. Cho-Chung

Alan M. Gewirtz

Cy A. Stein

Part I. Kill the Messenger: Gene Silencing by Nucleic Acid Molecules

Knock-down of the Cytoprotective Gene, Clusterin, to Enhance Hormone and Chemosensitivity in Prostate and Other Cancer

(15)

Martin Gleave

Kim N. Chi

Recognition of Chromosomal DNA in Human Cells by Peptide Nucleic Acids and Small Duplex RNAs

(10)

David R. Corey

Part II. Antisense and siRNA: Chemistry, Sequence Specificity, and Target Validation

Design and Development of Thermolytic DNA Oligonucleotide Prodrugs

(13)

Andrzej Grajkowski

Joao Pedras-Vasconcelos

Cristina Ausin

Daniela Verthelyi

Serge L. Beaucage

Rationally Targeted, Conformationally Constrained, Oxetane-Modified Oligonucleotides Demonstrate Efficient Gene-Silencing Activity in a Cellular System.

(13)

J. B. Opalinska

A. M. Gewirtz

Part III. Delivery Cellular and Phenotype Effect of Silencing Agents

In Vivo Potentialities of EWS-Fli-1 Targeted Antisense Oligonucleotides-Nanospheres Complexes.

(10)

Andrei Maksimenko

Valerie Polard

Marie Villemeur

Hind Elhamess

Patrick Couvreur

Jean-Remi Bertrand

Malam Aboubakar

Marina Gottikh

Claude Malvy

Endo-Porter: A Novel Reagent for Safe, Effective Delivery of Substances into Cells.

(14)

James E. Summerton

Tumor Reversion: Protein Kinase a Isozyme Switching.

(11)

Yoon S. Cho-Chung

Maria V. Nesterova

Part IV. Immune Modulation of and Resistance to Silencing Agents

Therapeutic Potential of Oligonucleotides Expressing Immunosuppressive TTAGGG Motifs.

(9)

Dennis M. Klinman

Ihsan Gursel

Sven Klaschik

Li Dong

Debbie Currie

Hidekazu Shirota

Breaking Tolerance to Tumors with Dendritic Cell-Based Immunotherapy.

(9)

Ines Mende

Edgar G. Engleman

Development of Resistance to RNAi in Mammalian Cells.

105

(14)

Zhi-Ming Zheng

Shuang Tang

Mingfang Tao

Part V. Transcription Silencing by Nucleic Acid Molecules

The Development of Bioactive Triple Helix-Forming Oligonucleotides.

119

(9)

Michael M. Seidman

Nitin Puri

Alokes Majumdar

Bernard Cuenouds

Paul S. Miller

Rowshon Alam

Transcription Factor Decoys: A New Model for Disease Intervention.

128

(12)

Michael J. Mann

DNA Damage Produced by 125I-Triplex-Forming Oligonucleotides as a Measure of Their Successful Delivery into Cell Nuclei.

140

(11)

Irina V. Panyutin

Olga A. Sedelikova

William M. Bonner

Igor G. Panyutin

Ronald D. Neumann

Targeted Genome Modification via Triple Helix Formation.

151

(11)

Jennifer M. Kalish

Peter M. Glazer

Part VI. Functional Genomics---Antisense/RNAi

``Promoter Array'' Studies Identify Cohorts of Genes Directly Regulated by Methylation, Copy Number Change, or Transcription Factor Binding in Human Cancer Cells.

162

(24)

Yipeng Wang

Jun Hayakawa

Fred Long

Qiuju Yu

Ann H. Cho

Gaelle Rondeau

John Welsh

Shalu Mittal

Ian de Belle

Eileen Adamson

Michael McClelland

Dan Mercola

Application of Expression Genomics for Predicting Treatment Response in Cancer

186

(10)

Khew-Voon Chin

Leah Alabanza

Kazuyuki Fujii

Kazuya Kudoh

Tsunekazu Kita

Yoshihiro Kikuchi

Zachariah E. Selvanayagam

Yick Fu Wong

Yong Lin

Wei Chung Shih

Stability Regulation of mRNA and the Control of Gene Expression.

196

(9)

Chris Cheadle

Jinshui Fan

Yoon S. Cho-Chung

Thomas Werner

Jill Ray

Lana Do

Myriam Gorospe

Kevin G. Becker

Part VII. Chemosensitivity Enhancement by Antisense and RNAi

Novel MDM2 p53-Independent Functions Identified through RNA Silencing Technologies.

205

(10)

Zhuo Zhang

Hui Wang

Mao Li

Elizabeth Rayburn

Sudhir Agrawal

Ruiwen Zhang

Application of XIAP Antisense to Cancer and Other Proliferative Disorders: Development of AEG35156/GEM®640.

215

(20)

Eric C. Lacasse

Ekambar R. Kandimalla

Peter Winocour

Tim Sullivan

Sudhir Agrawal

John W. Gillard

John Durkin

Part VIII. Nucleic Acid Therapeutics for Human Diseases

Induction of Apoptosis by G3139 in Melanoma Cells.

235

(11)

Luba Benimetskaya

Johnathan C. Lai

Anastasia Khvorova

Sijian Wu

Paul Miller

C. A. Stein

Zebularine: A Unique Molecule for an Epigenetically Based Strategy in Cancer Chemotherapy.

246

(9)

Victor E. Marquez

James A. Kelley

Riad Agbaria

Tisipi Ben-Kasus

Jonathan C. Cheng

Christine B. Yoo

Peter A. Jones

Chemoprevention with Protein Kinase A RIα Antisense in DMBA-Mammary Carcinogenesis.

255

(10)

Maria V. Nesterova

Yoon S. Cho-Chung

Index of Contributors

265

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Therapeutic Oligonucleotides : Transcriptional and Translational Strategies for Silencing Gene Expression

Table of Contents

Supplemental Materials