Transforming Growth Factor-Beta in Cancer Therapy

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ISBN: 9781588297150 | 1588297152
Cover: Hardcover
Copyright: 3/30/2008

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Transforming Growth Factor-[beta] in Cancer Therapy, Volumes I and II, provide a compendium of findings about the role of transforming growth factor-[beta] (TGF-[beta]) in basic and clinical biology and cancer treatment and therapy. The second volume, Cancer Treatment and Therapy, is divided into three parts. Part I examines TGF-[beta] in developing and advanced cancers. Part II details TGF-[beta] in cancer treatment and therapy. Part III includes an investigation into the development of inhibitors of TGF-[beta] signaling for therapy.

In Memoriam	p. v
Foreword	p. vii
Preface	p. ix
Biography	p. xiii
Contributors	p. xix
Transforming Growth Factor-[beta] in Developing and Advanced Cancers
Transforming Growth Factor-[beta] Signaling in Pancreas Development and Pancreatic Disease	p. 3
Role of Transforming Growth Factor-[beta] in the Pathogenesis of Human Head and Neck Squamous Cell Carcinoma	p. 21
TGF-[beta], Smads and Cervical Cancer	p. 33
TGF-[beta] Signaling and Biglycan in Pancreatic Cancer	p. 51
TGF-[beta] Signaling in Endometrial Cancer	p. 63
TGF-[beta] Ligands, TGF-[beta] Receptors, and Lung Cancer	p. 79
Role of TGF-[beta] in Osteolytic Bone Metastases	p. 95
Hormonal Regulation of Transforming Growth Factor-[beta] in Breast Cancer	p. 125
TGF-[beta] and Progression of Esophageal Cancer	p. 133
TGF-[beta] and HER2/ErbB2 and Breast Cancer Progression	p. 141
TGF-[beta] Dependent T-Cell Regulation in Colitis and Colon Cancer	p. 153
Role of Transforming Growth Factor-[beta] in the Kidney-Physiology and Pathology	p. 167
Perturbations of TGF-[beta] Signaling in Leukocytes as Drivers of Leukemogenesis and Epithelial Tumorigenesis	p. 181
Transforming Growth Factor-[beta] in Brain Functions and Dysfunctions	p. 203
Inhibition of TGF-[beta] Signaling in Multiple Myeloma and Its Bone Marrow Microenvironment	p. 219
Key Roles of TGF-[beta] and Smad3 in Prostate Cancer	p. 229
Smad Signaling in Leukemic Growth and Differentiation: Crosstalk Between Smad and Multiple Pathways Through Activation of the TGF-[beta] Type I Receptor	p. 247
Transforming Growth Factor-[beta] in Cancer Treatment and Therapy
High-Throughput Screening of Protein Interaction Networks in the TGF[beta] Interactome: Understanding the Signaling Mechanisms Driving Tumor Progression	p. 265
Tumor Suppressor and Pro-progression Roles for TGF-[beta] in Breast Cancer	p. 285
Tumor Suppressors p53 and TGF[beta] Converge to Regulate the Alpha-Fetoprotein Oncodevelopmental Tumor Marker	p. 309
TGF[beta]: Roles in DNA Damage Responses	p. 321
The Rationale for and Effects of Targeting TGF-[beta] for Glioma Therapy	p. 335
Tumor Suppressor Functions of TGF[beta]1 in T Cells	p. 353
Therapeutic Effects of Adenovirus-Mediated Gene Transfer of TGF-[beta] Signal Antagonists on Undesirable Epithelial-Mesenchymal Transition and Neovascularization	p. 367
Role of TGF-[beta] in Tumor Protection and Antitumor Immunity	p. 383
Regulation of Angiogenesis and Tumor Growth by Thrombospondin-1	p. 401
Cancer-Associated Fibroblasts and the Role of TGF-[beta]	p. 417
Adoptive Transfer of Tumor Reactive TGF-[beta] Insensitive CD8[superscript +] T-cells for Cancer Therapy	p. 443
DNA Methylation and Histone Deacetylation Inhibitors as Potential Therapeutic Agents for the Reconstitution of TGF-[beta] Signaling in Breast Cancer	p. 463
Reactive Stroma and Evolution of Tumors: Integration of Transforming Growth Factor-[beta], Connective Tissue Growth Factor, and Fibroblast Growth Factor-2 Activities	p. 475
TGF-[beta] Signaling and Vascular Morphogenesis	p. 507
Aberrant Transforming Growth Factor-[beta] Signaling in Human Pancreatic Cancer: Translational Implications	p. 523
TGF-[beta] and Stromal Influences Over Local Tumor Invasion	p. 537
TGF-[beta] at the Crossroads Between Inflammation, Suppression and Cancer	p. 553
Development of Inhibitors of Transforming Growth Factor-[beta] Signaling for Therapy
Transforming Growth Factor-[beta] (TGF-[beta]) Signaling Inhibitors in Cancer Therapy	p. 573
Targeting TGF-[beta] as a Strategy to Ameliorate Intestinal Side Effects of Radiation Therapy	p. 589
Targeting Transforming Growth Factor-[beta] in Metastasis: In Vitro and In Vivo Mechanisms	p. 609
Targeted Downregulation of TGF-[beta]2 with AP 12009 in Tumor Therapy	p. 635
Modulating TGF-[beta] Receptor Signaling: A Novel Approach of Cancer Therapy	p. 653
Engineering TGF-[beta] Traps: Artificially Dimerized Receptor Ectodomains as High-affinity Blockers of TGF-[beta] Action	p. 671
The Use of Virtual Screening in ALK5 Kinase Inhibitor Discovery and Validation of Orally Active ALK5 Kinase Inhibitors in Oncology	p. 685
Soluble Type II Transforming Growth Factor-[beta] Receptor Inhibits Tumorigenesis by Augmenting Host Antitumor Immunity	p. 697
Reversal of EMT by Small-Molecule Inhibitors of TGF-[beta] Type I and II Receptors: Implications for Carcinoma Treatment	p. 707
Soluble TGF-[beta] Type III Receptor Suppresses Malignant Progression of Human Cancer Cells	p. 723
Targeting Smad-Dependent TGF-[beta] Signaling with Peptide Aptamers	p. 737
Rationale for Anti-TGF-[beta] Antibody Therapy in Oncology	p. 757
Index	p. 775
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Transforming Growth Factor-Beta in Cancer Therapy

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