Transgenics in Endocrinology

, by Matzuk, Martin M.; Brown, Chester W.; Kumar, T. Rajendra, Ph.D.

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ISBN: 9780896037649 | 0896037649
Cover: Hardcover
Copyright: 8/1/2001

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A panel of expert clinical and basic investigators summarize the state-of-the-art in the use of transgenic technology in a broad range of endocrinological applications. Up-to-date and comprehensive, Transgenics in Endocrinology reviews the most recent developments in the analysis of endocrine physiology and its pathologies through mouse models, and provides a host of creative approaches to understand better the complex processes that are characteristic of hormonal systems.

Preface

Contributors

Germline Genetic Engineering Techniques in Endocrinology

(18)

Albert S. Y. Chang

Michael J. Reardon

Francesco J. DeMayo

The Transgenic Mouse in Studies of Mammalian Sexual Differentiation

(22)

Deanne J. Whitworth

Richard R. Behringer

The In Vivo Function of Mullerian-Inhibiting Substance During Mammalian Sexual Development

(20)

Yuji Mishina

Control of Ovarian Function

(30)

Julia A. Elvin

Martin M. Matzuk

Mouse Models to Study the Pituitary-Testis Interplay Leading to Regulated Gene Expression

(24)

Emiliana Borrelli

T. Rajendra Kumar

Paolo Sassone-Corsi

Functional Analysis of the Bc12 Gene Family in Transgenic Mice

115

(32)

Andrea J. Ross

Grant R. macGregor

The Role of C-Kit/Kit Ligand Axis in Mammalian Gametogenesis

147

(18)

Peter J. Donovan

Maria P. de Miguel

Gene Knockout Approaches to Steroidogenesis

165

(8)

Tomonobu Hasegawa

Liping Zhao

Kathleen M. Caron

Morag Young

Keith L. Parker

The Progesterone Receptor Knockout Mouse Model: New Insights into Progesterone Action In Vivo

173

(32)

John P. Lydon

Selma Soyal

Bert W. O'Malley

Preeti M. Ismail

Knockout and Transgenic Mouse Models that Have Contributed to the Understanding of Normal Mammary Gland Development

205

(26)

Tiffany N. Seagroves

Jeffrey M. Rosen

Prolactin and the Prolactin Receptor

231

(14)

Nelson D. Horseman

Transgenic Models for Oxytocin and Vasopressin

245

(16)

Larry J. Young

Thomas R. Insel

Glycoprotein Hormones: Transgenic Mice as Tools to Study Regulation and Function

261

(36)

Ruth A. Keri

John H. Nilson

Genetic Approaches to the Study of Pituitary Follicle-Stimulating Hormone Regulation

297

(22)

Daniel J. Bernard

Teresa K. Woodruff

Transgenic Analysis of the Proopiomelanocortin Neuroendocrine Systems

319

(20)

Malcolm J. Low

Marcelo Rubinstein

E. Cheng Chan

Overexpression and Targeted Disruption of Genes Involved in the Control of Growth, Food Intake, and Obesity

339

(32)

Andrzej Bartke

Michael Michalkiewicz

Insulin and Insulin-Like Growth Factors: Targeted Deletion of the Ligands and Receptors

371

(14)

Carolyn A. Bondy

Domenico Accili

Use of Transgenic Animals in Skeleton Biology

385

(16)

Thomas Gunther

Mary Jo Doherty

Gerard Karsenty

Transgenic Mouse Models of Prostate Cancer

401

(26)

Robert J. Matusik

Naoya Masumori

Tania Thomas

Thomas Case

Manik Paul

Susan Kasper

Scott B. Shappell

Neural- and Endocrine-Cell-Specific Immortalization Using Transgenic Approaches

427

(42)

T. Rajendra Kumar

Index

469

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Transgenics in Endocrinology

Summary

Table of Contents

Supplemental Materials