Transplantation and Mechanical Support for End-Stage Heart and Lung Disease, 2 Volume Set

Comprehensive textbook covering all aspects of the care of patients with advanced heart or lung disease

Transplantation and Mechanical Support for End-Stage Heart and Lung Disease is the most comprehensive and contemporary textbook available that addresses the medical and surgical treatment options for patients with end-stage heart and lung disease. All facets of these complex and resource-intensive therapies are covered by leading experts — including the basics of transplant immunology, databases, regulatory and ethical aspects of transplantation and conventional and new modalities of donor organ harvest.

Transplantation and Mechanical Support for End-Stage Heart and Lung Disease includes further information on topics such as:

• Historical developments that facilitated heart and lung transplantation; engineering advances in continuous flow technologies
• Transplant organizations, oversight, structure, process, databases and registries in the thoracic transplants and MCS field
• Current strategies in immune modulation, desensitization protocols and mechanisms of allograft rejection and tolerance/immunosenescence
• Detailed descriptions of donor and recipient surgical procedures as well as comprehensive implantation techniques for all available short- and long-term mechanical circulatory support devices, including ECMO
• Organ allocation and prioritization, donor evaluation, high risk donors, marginal donors, and risk assessment

Richly enhanced with summary tables and color illustrations to provide an engaging and supportive learning experience, the book will serve as a highly valuable source of contemporary knowledge for medical students, residents, nurses, perfusionists, physicians and surgeons involved in the care of these desperately ill group of patients.

“This comprehensive book covers all aspects of advanced heart and lung failure treatment, including shock, short-term and durable mechanical assistance, as well as transplantation. The in-depth information will be welcome by newcomers in the field as well as seasoned veterans.”
—Andreas Zuckermann, M.D Vice-Chair, Department of Cardiac Surgery, Director of Cardiac Transplantation Program, Medical University of Vienna, Vienna General Hospital

“This comprehensive tour-de-force compendium covers practical issues of clinical administration, program development, care pathways, ongoing challenges and opportunities in each treatment area as a must go-to reference for guidance in the rapidly evolving fields of mechanical circulatory support and transplantation.”
—Mandeep R. Mehra, MBBS, MSc, FRCP Executive Director, Center for Advanced Heart Disease, Brigham and Women’s Hospital, Harvard Medical School

“This unique textbook authored by key opinion leaders is a refreshing ???wind of change??? in our field, one that will well serve all professionals involved in the care of end-stage heart and lung patients for many years to come.”
—Marcelo Cypel MD, MSc, FACS, FRCSC Surgical Director Ajmera Transplant Centre at UHN , University of Toronto

Yaron D. Barac, M.D, Ph.D

Associate Professor of Surgery and Cardiovascular Physiology

Director; Heart and Lung Transplantation and Mechanical Circulatory Support Programs

Director; The Cardiothoracic Surgery Translational Research Lab

The Division of Cardiovascular and Thoracic Surgery, Rabin Medical Center, Tel Aviv University, Israel

Mani A. Daneshmand, M.D

Andrew J. McKelvey Professor of Lung Transplant Surgery

Director, Section of Thoracic Transplant and MCS Surgery

Division of Cardiothoracic Surgery, Department of Surgery

Emory University School of Medicine

Scott C. Silvestry, M.D

Co-Executive Medical Director, Heart Lung & Vascular Institute

Surgical Director, Thoracic Transplant Programs

AdventHealth Transplant Institute,

AdventHealth Orlando

Daniel J. Goldstein, MD

Professor and Vice-Chair

Surgical Director, Cardiac Transplantation & Mechanical Assistance Programs

Department of Cardiothoracic and Vascular Surgery

Montefiore Medical Center

Albert Einstein College of Medicine

Contents

Section IX The MCS Patient 785

Stephan Schueler

56 Postoperative ICU Care for Mechanical Circulatory Support Patients 787

Nicholas C. Cavarocchi

57 Post-ICU LVAD Course 797

Melissa Lyle and Divya Gupta

58 The VAD Coordinator’s Role: Education and Team Communication 805

Heidi Craddock and Christy Kay

59 The LVAD Patient Bridging to Wellness: Psychological Assessment and Rehabilitation 812

Mary Amanda Dew

60 LVAD Clinic: Outpatient Monitoring and Causes for Readmission 833

Nancy K. Sweitzer and Sophia Airhart

61 Hemodynamic Optimization of the LVAD Patient 849

Nikhil Narang, Gabriel Sayer, and Nir Uriel

62 Myocardial Recovery During LVAD Support 858

Christos P. Kyriakopoulos, Craig H. Selzman, and Stavros G. Drakos

Section X MCS-Related Complications in the Chronic Patient 881

Joseph G. Rogers

63 Right Heart Failure: Risk Scores and Management 883

Brent C. Lampert and Jeffrey J. Teuteberg

64 LVAD-Associated Acquired von Willebrand Syndrome and Gastrointestinal Bleeding: Pathophysiology, Etiologies, and Management 898

Sanjhai L. Ramdeen and Carlo R. Bartoli

65 Mechanical Circulatory Support Infections 907

Gerard Giblin, Ciara O’Connor, Emer Joyce, and Margaret M. Hannan

66 Pump Thrombosis: Medical and Surgical Management 932

Andrew Xanthopoulos, Filippos Triposkiadis, and Randall C. Starling

67 Neurologic Complications: Pathophysiology, Incidence, Types, Prevention, and Management 945

Paolo C. Colombo, Chinwe Ibeh, Kara R. Melmed, and Joshua Willey

68 Renal Dysfunction in MCS Patients: Perioperative and Long-Term Considerations 966

Natasha A. Vedage and Meredith A. Brisco-Bacik

69 De Novo Aortic Insufficiency 977

Jennifer Cowger

Section XI The LVAD Program and Future Directions 987

Daniel J. Goldstein

70 Regulatory and Miscellaneous Aspects of an LVAD Program 989

Christina Cheyne, Igor Gosev, and Sunil Prasad

71 Current Limitations and Characteristics of Next-Generation Ventricular Assist Devices 996

Yuji Kaku, Yoshifumi Naka, and Daniel Burkhoff

72 MCS and Novel Adjunctive Therapies: An Update 1011

Doris A. Taylor, Lourdes I. Chacon, Camila Hochman-Mendez, and Luiz C. Sampaio

73 Artificial Intelligence and Machine Learning in MCS 1021

Manreet Kanwar, Marek J. Druzdzel, Faezeh Movahedi, and Jim Antaki

Lung Transplant

Section XII The Pretransplant Phase: Recipient 1035

Mani A. Daneshmand

74 Recipient Selection and the Lung Transplant Window for Adult and Pediatric Patients 1037

David C. Neujahr and William R. Hunt

75 Advanced Lung Disease 1053

Cynthia Jane Gries

76 The Acute Lung Failure Patient and Temporary Mechanical Support 1070

Purav Shah, Maria C. Creel, and Satish Chandrashekaran

77 Preoperative Optimization for Lung Transplant 1081

Andrew M. Vekstein, John C. Haney, John M. Reynolds, and Jacob A.Klapper

78 Lung Transplant Waitlist Management 1089

Joshua B. Smith and Alice L. Gray

Section XIII The Pretransplant Phase: Donor 1101

Yaron D. Barac

79 Prioritization: Candidate Selection and Organ Allocation Systems 1103

Are Martin Holm andMatthew G. Hartwig

80 Donor Lungs Evaluation 1110

Louis Stein, Alex Leung, Yaron D. Barac, Mani A. Daneshmand, and Yuri Pesachovitz

81 Lung Transplantation: Marginal Donors and Risk Assessment 1119

Laura L. Donahoe and Shaf Keshavjee

82 Organ Procurement and Preservation 1132

Reshma Biniwale and Abbas Ardehal

83 Machines and Donation After Circulatory Death (DCD) in Lung Transplantation 1145

Gabriel Loor and Pablo Sanchez

Section XIV The Transplant Phase 1163

Mani A. Daneshmand

84 Components of the Lung Transplant Team 1165

Keshava Rajagopal

85 Anesthesia and Hemodynamic Management for Lung Transplantation 1167

Angela Pollak, Charles Overbeek, and Brandi Bottiger

86 Techniques in Lung Transplantation 1183

Maziar Khorsandi, Jeffrey Keenan, and Matthew Hartwig

87 Technical Considerations in the Complex Recipient 1193

Jamil F. Borgi and Stephen J. Forest

88 Taking the First Breath: ICU Care of the Lung Transplant Patient 1204

Daniel Herr and Patrick Odonkor

Section XV The Post-Transplant Phase 1215

Yaron D. Barac

89 Post-Transplant Phase: Issues in the Early Postoperative Period 1217

John Mackintosh and Peter Hopkins

90 Post-Transplant Phase: From ICU Discharge to Hospital Discharge 1240

Osnat Shtraichman and Mordechai R. Kramer

91 Lung Transplant Rejection 1268

Caroline Patterson and Martin Goddard

92 Transplant Infectious Diseases 1288

Grace Chan, Breda Lynch, Michelle Murray, and Margaret M. Hannan

93 Post-Transplant Complications 1317

Jagan Murugachandran, Debra Thomas, and Jasvir Parmar

94 Post-Transplant Other Adverse Events 1333

Andres Pelaez and Karoun H. Bagamian

95 Survival and Quality of Life Post Lung Transplantation 1345

Attawar Sandeep, Vijil Rahulan, and Unmil Shah

Section XVI Thoracic Transplant in a Long-Term Perspective 1359

Mani A. Daneshmand

96 The Future of Heart and Lung Transplantation 1361

Jane M.O., David C. Becerra, and Joren C. Madsen

97 Heart and Lung Xenotransplantation 1389

Jane O., Cynthia L. Miller, and Joren C. Madsen

Index 1404

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