Tuberculosis

The reemergence of TB is a major health problem; as is its persistence as the largest cause of death from a single infectious disease in the world. Because of the lack of support, and the difficulties in working with Mycobacterium tuberculosis, research and knowledge have lagged behind most infectious diseases. This book summarises the current state of knowledge about tuberculosis - its global importance, epidemiology, molecular biology and immunology - in a single book. It is designed to present what is currently known and to indicate directions for future research on the disease organism, its pathogenesis and treatment.

Introduction to Tuberculosis;he global problem;istory of tuberculosis;verview of clinical tuberculosis, Epidemiology of tuberculosis;urrent laboratory diagnosis of tuberculosis;nimal models of tuberculosis;iohazard considerations;ycobacteriophages;lasmids;ransposons, insertion elements and restriction polymorphisms;pproach to genomic structure;xpression of foreign genes in mycobacteria;enetic strategies for analyzing virulence;he Physiology of M tuberculosis;ltrastructure;ipids and carbohydrates of M tuberculosis;Proteins and antigens of M tuberculosis;Metabolism of M tuberculosis;Transport in M tuberculosis;The Immunology of Tuberculosis;mmune mechanisms of protection;cell responses and lymphokines;and T cell recognition;athogenesis of tuberculosis;athogenesis of tuberculosis in AIDS;ew Approaches to Prevention and Treatment of Tuberculosis;olecular approaches to diagnosis;CG and new approaches to vaccines for tuberculosis;earch for new drugs;olecular epidemiology;perational and economic issues;ultivation of M tuberculosis