Tumor Models in Cancer Research

The past 6 years since the first edition of this book have seen great progress in the development of genetically engineered mouse (GEM) models of cancer. These models are finding an important role in furthering our understanding of the biology of malignant disease. A comfortable position for GEM models in the routine conduct of screening for potential new therapeutics is coming more slowly but is coming. Increasing numbers of genetically engineered mice are available, some with conditional activation of oncogenes, some with multiple genetic changes providing mouse models that are moving closer to the human disease.

Introduction
Perspectives on the History and Evolution of Tumor Models	p. 3
Transplantable Syngeneic Rodent Tumors
Murine L1210 and P388 Leukemias	p. 23
Transplantable Syngeneic Rodent Tumors: Solid Tumors in Mice
B16 Murine Melanoma: Historical Perspective on the Development of a Solid Tumor Model	p. 79
Human Tumor Xenografts
Human Tumor Xenograft Efficacy Models	p. 99
Imaging the steps of metastasis at the macro and cellular level with fluorescent proteins in real time	p. 125
Patient-Derived Tumor Models and Explants	p. 167
The Pediatric Preclinical Testing Program	p. 195
Imaging Efficacy in Tumor Models	p. 215
Carcinogen-Induced Tumors
Mammary Cancer in Rats	p. 245
Disease and Target-Specific Models
Animal Models of Melanoma	p. 259
Experimental Animal Models for Investigating Renal Cell Carcinoma Pathogenesis and Preclinical Therapeutic Approaches	p. 287
Animal Models of Mesothelioma	p. 307
The Use of Mouse Models to Study Leukemia/Lymphoma and Assess Therapeutic Approaches	p. 325
Spontaneous Companion Animal (Pet) Cancers	p. 353
Genetically Engineered Mouse Models of Cancer
Genetically Engineered Mouse Models of Pancreatic Ductal Adenocarcinoma	p. 377
Transgenic Adenocarcinoma of the Mouse Prostate: A Validated Model for the Identification and Characterization of Molecular Targets and The Evaluation of Therapeutic Agents	p. 397
The Utility of Transgenic Mouse Models for Cancer Prevention Research	p. 423
Metastasis Models
Models for Evaluation of Targeted Therapies of Invasive and Metastatic Disease	p. 447
Normal Tissue Response Models
Animal Models of Toxicities Caused by Anti-Neoplastic Therapy	p. 499
Bone Marrow as a Critical Normal Tissue that Limits Drug Dose/Exposure in Preclinical Models and the Clinic	p. 521
Anesthetic Considerations for the Study of Murine Tumor Models	p. 553
Experimental Methods and Endpoints
Preclinical Tumor Response End Points	p. 571
Tumor Cell Survival	p. 607
Apoptosis In Vivo	p. 625
Transparent Window Models and Intravital Microscopy: Imaging Gene Expression, Physiological Function and Therapeutic Effects in Tumors	p. 641
Index	p. 681
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Tumor Models in Cancer Research

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