The Ubiquitous Roles of Cytochrome P450

Helmut Sigel, Astrid Sigel and Roland K.O. Sigel, in close cooperation with John Wiley & Sons launch a new Series "Metal Ions in Life Sciences".There exists a whole range of books on Cytochromes P450, but none with the focus of this volume. This new volume in the Series concentrates on current hot topics in the area and tries to work out the underlying common developments.As a result the reader will find a systematic account of new results in this exciting research area. The table of contents gives an idea on the wide span of chapters, starting with overviews and the presentation of specific systems, and ending with chapters on carbon-carbon bond cleavage by P450 sytems, drug metabolism as catalyzed by P450 systems, decomposition of xenobiotics by P450 enzymes and design and engineering of new P450 systems.

Astrid Sigel has studied languages and was an editor of the Metal Ions in Biological Systems series (until Volume 44) and also of the Handbooks on Toxicity of Inorganic Compounds (1988), on Metals in Clinical and Analytical Chemistry (1994; both with H.G. Seiler), and on Metalloproteins (2001; with Ivano Bertini) (Dekker, New York).

Helmut Sigel is Emeritus Professor (2003) of Inorganic Chemistry at the University of Basel, Switzerland, and a previous editor of the MIBS series until Volume 44. He serves on various editorial and advisory boards, published over 300 articles on metal ion complexes of nucleotides, coenzymes, and other ligands of biological relevance, and lectured worldwide. He was named Protagonist in Chemistry (2002) by ICA (issue 339); among further honors are the P. Ray Award (Indian Chemical Society, of which he is also an Honorary Fellow), the Werner Award (Swiss Chemical Society), a Doctor of Science honoris causa degree (Kalyani University, India), appointments as Visiting Professor (e.g., Austria, China, UK) and Endowed Lectureships.

Roland K.O. Sigel is Assistant Professor (2003) of Inorganic Chemistry at the University of Zürich, Switzerland, endowed with a Förderungsprofessur of the Swiss National Science Foundation. He received his doctoral degree summa cum laude (1999) from the University of Dortmund, Germany, working with Bernhard Lippert; thereafter he spent nearly three years at Columbia University, New York, USA, in the group of Anna Marie Pyle (now Yale University); during the six years abroad he received several fellowships from various sources. His research focuses on the structural and catalytic role of metal ions in ribozymes, especially group II introns, and on related topics. He was also an editor of Volumes 43 and 44 of the MIBS series.

Historical Development And Perspectives Of The Series
Preface To Volume 3
Contributors To Volume 3
Titles Of Volumes 1-44 In The Metal Ions In Biological Systems Series
Contents Of Volumes In The Metal Ions In Life Sciences Series
Diversities And Similarities In P450 Systems: An Introduction
Oxygenases: Mediators of Biochemical Diversity
P450 Superfamily: Diversity at the Sequence Level
Diversity of P450 Structures: Folds and Conformations for Functions
Diversity in P450 Mechanisms
Diversity in Regulation Across the Superfamily
Diversity in the Evolution of Common Metabolic Functions
Summary and Outlook
Acknowledgments
Abbreviations
References
Structural And Functional Mimics Of Cytochromes P450
Introduction
Iron Porphyrins Carrying a Thiolate or Modified Thiolate Ligand
Structurally Remote P450 Mimics
Concluding Remarks
Acknowledgments
Abbreviations
References
Structures Of P450 Proteins And Their Molecular Phylogeny
Introduction
P450 Evolution
P450 Families and Subfamilies
P450 Structures
Variation in P450 Function and Fold
Archaeon P450s
Summary and Conclusions
Acknowledgments
Abbreviations
References
Aquatic P450 Species
Introduction: 'P450s Under the Surface'
Diversity of Aquatic Species
P450 Activities in Aquatic Invertebrates
Aquatic P450 Gene Families Identified
How Can We Use Information About P450s in Aquatic Species?
Conclusions and Outlook
Acknowledgments
Abbreviations
References
The Electrochemistry Of Cytochrome P450
Introduction
Redox Titration (Potentiometric Equilibrium) Measurements
Voltammetric (Dynamic) Measurements
Conclusions
Acknowledgments
Abbreviations
References
P450 Electron Transfer Reactions
Introduction
Catalytic Cycles
Electron Tunneling Wires
Concluding Remarks
Acknowledgments
Abbreviations
References
Leakage In Cytochrome P450 Reactions In Relation To Protein Structural Properties
Introduction
Protein Structural Parameters
The Reaction Cycle of Cytochrome P450
Protein Structural Parameters and Extent of Competitive Reactions
Concluding Remarks
Acknowledgments
Abbreviations
References
Cytochromes P450 - Structural Basis For Binding And Catalysis
Introduction
Ligand Binding: Substrate Recognition and Access to the Distal Pocket
Architecture of the Active Site of CYP101
The Distal Acid-Alcohol Pair
Experimental Characterization of Reaction Intermediates. Radiolysis as a Tool to Study Redox Reactions
Crystal Structures of Oxy-Ferrous Complexes
Mechanism: Summary, Conclusions, Speculations
Acknowledgments
Abbreviations
References
Beyond Heme-Thiolate Interactions: Roles Of The Secondary Coordination Sphere In Cytochrome P450 Systems
Overview of Cytochrome P450 Active Site Structure
Secondary Coordination Sphere on the Proximal Side
Secondary Coordination Sphere on the Distal Side
Summary and Outlook
Acknowledgments
Abbreviations
References
Interactions Of Cytochrome P450 With Nitric Oxide And Related Ligands
Introduction: Interactions of Ligands and Substrates with P450 Enzymes: General Features
Nitric Oxide and Its Interactions with P450S
Interactions of Imidazoles and Substituted Imidazoles with P450S
Other Ligands and Inhibitors of P450 Function
Conclusions and Future Prospects
Acknowledgments
Abbreviations
References
Cytochrome P450-Catalyzed Hydroxylations And Epoxidations
Introduction
The Cytochrome P450 Enzymes
Three-Dimensional Structures of the Active Sites of Cytoch
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The Ubiquitous Roles of Cytochrome P450 Proteins

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