Upstream Industrial Biotechnology, 2 Volume Set

Editor-in-Chief, Dr. Michael C. Flickinger is the Associate Director for Academic Programs of the Golden LEAF Biomanufacturing Training and Education Center (BTEC) and a Professor of Microbiology and Chemical and Biomolecular Engineering at North Carolina State University, Raleigh.
Dr. Flickinger was Director of the University of Minnesota's Institute for Advanced Studies in Biological Process Technology, which was later renamed the Biotechnology Institute ), and a Professor of Biochemistry, Molecular Biology and Biophysics at the University of Minnesota, St. Paul. Prior to coming to Minnesota Dr. Flickinger was Director of the Fermentation Program at the National Cancer Institute in Frederick, Maryland.
Dr. Flickinger received his academic training at the University of Wisconsin, Madison.?(B.S.?(1973) in microbial biochemistry;? M.S. (1975) and Ph.D.?(1977) in pharmaceutical biochemistry.)? He did his postdoctoral work at the Laboratory for Renewable Resources Engineering? in the School of Chemical Engineering, Purdue University.
He is Editor-in-Chief of the Encyclopedia of Industrial Biotechnology (Wiley, 2010) and Co-Editor of the Encyclopedia of Bioprocess Technology: Fermentation, Biocatalysis and Bioseparation (Wiley, 1999).

VOLUME I: EXPRESSION SYSTEMS & PROCESS DEVELOPMENT

PREFACE xi

CONTRIBUTORS xiii

PART I INTRODUCTION 3

PART II INDUSTRIAL CELL GROWTH AND GENE EXPRESSION SYSTEMS 7

1 Animal Cells, Suspension Culture 9
John R. Birch

2 Baculovirus Expression Systems 19
Robert D. Possee, Richard B. Hitchman, and Linda A. King

3 Baculovirus Kinetics, Insect Culture 33
Leslie Chan, Steve Reid, and Lars Keld Nielsen

4 Cell Culture, Aseptic Techniques 49
John M. Davis and Kevin L. Shade

5 Cell Cycle in Bioprocesses 71
Mariam Naciri and Mohamed Al-rubeai

6 Cell Growth and Protein Expression Kinetics 85
Dhinakar S. Kompala

7 Cell Viability Measurement 97
Ning Wei and Benjamin Sommer

8 Contamination Detection in Animal Cell Culture 105
Carol Mclean and Colin Harbour

9 Culture Collections and Biological Resource Centers (BRCs) 131
David Smith

10 Culture Preservation 153
Robert L. Gherna

11 Expression and Secretion of Heterologous Proteins, Bacillus and Other Gram-Positive Bacteria 163
Boyke Bunk, Rebekka Biedendieck, Dieter Jahn, and Patricia S. Vary

12 Gene Expression in Human Cells 181
Marco A. Cacciuttolo, Gene Lee, John Chon, and John Lewis

13 Gene expression in Pichia and other methylotroph yeast 195
Koti Sreekrishna

14 Gene Expression in Recombinant Animal Cells and Transgenic Animals 213
Richard M. Twyman and Bruce Whitelaw

15 Inoculum Expansion Methods, Animal Cell Lines 297
Claudia Kloth, Glenn Maclsaac, Haile Ghebremariam, and Alahari Arunakumari

16 Insect Cell Culture 311
Someet Narang, Erik M. Whiteley, Sunyia Hussain, and Michael J. Betenbaugh

17 Kinetics of Microbial Growth 331
Nicolai S. Panikov

18 Microalgae, Mass Culture Methods 371
Emílio Molina Grima, Jose María Fernández Sevilla, and Francisco Gabriel Acién Fernández

19 Microbial Growth Measurement 399
Arthur L. Koch

20 Microbial Media Composition 413
Rosalie J. Cote

21 Microscopic Characterization of Cells 437
Erwin Huebner

22 Mycoplasma Contamination of Cell Cultures 467
Cord C. Uphoff and Hans G. Drexler

23 Protein Glycosylation: Analysis, Characterization, and Engineering 489
Mikael R. Andersen, Jong Hyun Nam, and Susan T. Sharfstein

24 Secretion of Heterologous Proteins, Gram Positive Bacteria 543
Eric Morello, Isabelle Poquet, Philippe Langella

25 Soluble Protein Expression in Bacteria 557
Catherine H. Schein

PART III MEDIA, CELL LINES AND PROCESS DEVELOPMENT 579

26 Animal Cell Culture Media 581
Natarajan Vijayasankaran, Jincai Li, Robert Shawley, Aaron Chen, Masaru Shiratori, Martin Gawlitzek, Feng Li, Robert Kiss, and Ashraf Amanullah

27 Animal Cell Culture, Effects of Osmolality and Temperature 599
James C. Warren and Shyamsundar Subramanian

28 Animal Cell Stability 617
Martin S. Sinacore, Timothy S. Charlebois, Denis Drapeau, Mark Leonard, Scott Harrison, and S. Robert Adamson

29 Animal Cell Types, Hybridomas 635
K. Heilmann and B. Micheel

30 Antibody Production, Human Recombinant 645
Stefan Dübel

31 Antifoams and Pluronic Polyols, Cell Protection 663
David W. Murhammer

32 Biominiaturization of Bioreactors 669
Michael A. Hanson and Govind Rao

33 Inoculum Preparation 699
Craig J.L. Gershater

34 Microcarrier Culture 711
Susan T. Sharfstein and Christian Kaisermayer

35 Monoclonal Antibody Production, Cell Lines 733
Julia F. Markusen and David K. Robinson

36 Plant Cell Culture, Laboratory Techniques 747
Mark Richard Fowler

37 Scale-Up of Biotechnological Processes 759
Marko Zlokarnik

VOLUME II: EQUIPMENT, PROCESS DESIGN, SENSING, CONTROL, AND cGMP OPERATIONS

PREFACE ix

CONTRIBUTORS xi

PART IV BIOREACTOR DESIGN, ENGINEERING, PROCESS SENSING AND CONTROL 789

38 Aeration, Mixing, and Hydrodynamics in Animal Cell Bioreactors 791
Ruben Godoy-Silva, Claudia Berdugo, and Jeffrey J. Chalmers

39 Biocatalytic Membrane Reactors 821
Lidietta Giorno and Enrico Drioli

40 Bioreactor Scale-Down 847
Laura A. Palomares, Alvaro R. Lara, and Octavio T. Ramírez

41 Bioreactor Scale-Up 863
Laura A. Palomares and Octavio T. Ramírez

42 Bioreactors: Airlift Reactors 887
J.C. Merchuk and F. Garcia Camacho

43 Bioreactors, Continuous Culture of Plant Cells 955
H.J.G. Ten Hoopen

44 Bioreactors, Fluidized-Bed 963
Winfried Storhas

45 Bioreactors, Gas-Treatment 979
Graham Andrews and William Apel

46 Bioreactors, Perfusion 995
Wei Wen Su

47 Bioreactors: Rotating Biological Contactors 1013
Susana Cortez, Pilar Teixeira, Rosário Oliveira, and Manuel Mota

48 Bioreactors, Stirred Tank for Culture of Plant Cells 1031
Pauline M. Doran

49 Cell Immobilization, Engineering Aspects 1069
Ronnie Willaert

50 Fermenter/Bioreactor Design 1101
Marvin Charles and Jack Wilson

51 Gas-Holdup in Bioreactors 1137
Christian Sieblist and Andreas Lübbert

52 Immobilization of Proteins and Enzymes, Mesoporous Supports 1147
Martin Hartmann and Dirk Jung

53 Immobilized Cells 1179
Manojlovic Verica, Bugarski Branko, and Nedovic Viktor

54 Immobilized Enzymes 1201
Jose M. Guisan, Lorena Betancor, and Gloria Fernandez-Lorente

55 Impeller Selection, Animal Cell Culture 1219
Alvin W. Nienow

56 Mammalian Cell Bioreactors 1233
Weichang Zhou, Gargi Seth, Maria J. Guardia, and Wei-Shou Hu

57 Mammalian Cell Culture Reactors, Scale-Up 1245
J. Bryan Griffiths

58 Mass Transfer 1261
Yusuf Chisti

59 Oxygen Transfer Rate Determination Methods 1303
Felix Garcia-Ochoa and Emilio Gomez

60 Photobioreactors 1327
Mario R. Tredici, Graziella Chini Zittelli and Liliana Rodolfi

61 Rheological Behavior of Fermentation Fluids 1347
Colin R. Thomas and Grainne L. Riley

62 Rheology of Filamentous Microorganisms, Submerged Culture 1359
Maria Papagianni

63 Sampling and Sample Handling for Process Control 1377
Bo Mattiasson and Martin Hedström

64 Solid State Fermentation, Kinetics 1387
David A. Mitchell, Deidre M. Stuart, and Robert D. Tanner

65 Solid Substrate Fermentation, Automation 1413
Mario Fernández-fernández and J. Ricardo Pérez-correa

66 Stainless Steels 1427
C.P. Dillon

67 Static Mixing, Fermentation Processes 1435
Radu Z. Tudose and Maria Gavrilescu

68 Transfer Phenomena in Multiphase Systems 1451
Rodica-Viorica Roman

PART V PROCESS ANALYTICAL TECHNOLOGIES (PAT) 1469

69 Bioprocess and Fermentation Monitoring 1471
Michael Pohlscheidt, Salim Charaniya, Marco Jenzsch, Christopher Bork, Tim L. Noetzel, and Andreas Luebbert

70 Flow Injection Analysis in Industrial Biotechnology 1493
Elo Harald Hansen and Manuel Miró

71 Fluorescence Techniques for Bioprocess Monitoring 1511
Fabienne Anton, Carsten Lindemann, Bernd Hitzmann, Kenneth F. Reardon, and Thomas Scheper

72 Off-Line Analysis in Animal Cell Culture 1523
Heino Büntemeyer

73 Process Analytical Technology: Strategies for Biopharmaceuticals 1543
Anurag S. Rathore and Gautam Kapoor

74 Vent Gas Analysis 1567
David Pollard and Jens Christensen

PART VI UPSTREAM cGMP OPERATIONS 1585

75 Antibody Manufacture, Disposable Systems 1587
Regine Eibl and Dieter Eibl

76 Bioreactor Operations 1595
David R. Gray

77 Bioreactors, Cell Culture, Commercial Production 1635
Tan-Che Zhou, Wen-Wen Zhou, Weiwei Hu, and Jian-Jiang Zhong

78 Biotransformation, Process Optimization 1665
Lutz Hilterhaus, Andreas Liese, and Udo Kragl

79 Foam Formation and Control in Bioreactors 1679
Frank Delvigne and Jean-Paul Lecomte

80 Pilot Plants, Design and Operation 1695
Beth H. Junker

81 Shear Sensitivity 1719
Yusuf Chisti

82 Sterilization and Decontamination, Bioprocess Equipment 1763
Peter L. Roberts

INDEX 1781

The New copy of this book will include any supplemental materials advertised. Please check the title of the book to determine if it should include any access cards, study guides, lab manuals, CDs, etc.

The Used, Rental and eBook copies of this book are not guaranteed to include any supplemental materials. Typically, only the book itself is included. This is true even if the title states it includes any access cards, study guides, lab manuals, CDs, etc.