Vector Targeting for Therapeutic Gene Delivery

"...very informative and comprehensive...belongs on the shelf ofevery library and lab providing essential resources for research onvector design or delivery."-Cancer Biology and TherapyThis comprehensive volume presents the most recent advances in target definitiontechnology and provides a detailed overview on the rational design of targetedvectors for gene therapy. A theoretical framework for advanced vector design is provided that integrates all of the allied sciences relevant to the study of vector targeting. The text discusses the basic underlying science and then leads to discussions of the various viral vectors and methods of definingtargets. Finally, an expert outlook on promising therapeutic applications is offered.

David T. Curiel, M.D. heads the Gene Therapy Center of the University of Alabama at Birmingham. His scientific training includes tenure at the National Institutes of Health in Bethesda, Maryland and at the Pulmonary Branch of the National Heart, Lung, and Blood Institute from 1985-1989, as well as a fellowship in Biotechnology at the National Cancer Institute, Navy Medical Oncology Branch from 1989-1990. Dr. Curiel has been at the University of Alabama at Birmingham since 1993 and is currently Director of the Gene Therapy Center as well as Director of the Division of Human Gene Therapy. He is also Jeanne and Anne Griffin Chair of Women's Cancer Research, and Professor of Experimental Gene Therapy at the Free University of Amsterdam. Joanne T. Douglas, Ph.D. is an Assistant Professor in the Division of Human Gene Therapy at the University of Alabama at Birmingham.

Preface.

Contributors.

PART I: TRANSDUCTIONALLY TARGETED VECTORS--NONVIRAL.

Alternative Strategies for Targeted Delivery of Nucleic Acid-Liposome Complexes (N. Templeton).

Targeted Gene Delivery via Lipidic Vectors (S. Li, et al.).

Immunoliposomes: A

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Vector Targeting for Therapeutic Gene Delivery

Summary

Author Biography

Table of Contents

Supplemental Materials