Viral Hepatitis

The 4^th edition of Viral Hepatitis covers comprehensively the entire complex field of infections caused by all of the different hepatitis viruses, which affect many millions of people throughout the world with considerable morbidity and mortality.

Howard Thomas and Arie Zuckerman are joined by Anna Lok from the USA and Stephen Locarnini from Australia as Editors.  They have recruited leading researchers and physicians from many countries, who have produced an authoritative account of current knowledge and research on this important infection, including new insights into immune response to HBV and HCV. 

The result is a comprehensive account on all aspects of viral hepatitis, including rapid advances in the diagnosis, management, treatment and prevention of a complex infection, which in the case of hepatitis B, C and D may lead to severe complications including chronic hepatitis, cirrhosis and hepatocellular carcinoma.

The latest edition of Viral Hepatitis offers an essential resource of current information for hepatologists, gastroenterologists, infectious diseases specialists and other clinicians, researchers, public health physicians and National and International Health Authorities.

Arie Zuckerman is chair of the Hepatitis B Foundation UK. He was the Director of?WHO Collaborating Centre for Reference and Research on Viral Hepatitis from 1974-1989 and 1990-2006. He was also?Principal and Dean of the Royal Free and University College Medical School and Principal and Dean of the Royal Free Hospital School of Medicine.

Howard Thomas?is Vice President of British Liver Trust, 1993-present and Hepatitis B Foundation — Trustee, 2005-present. He was also President of British Association for the Study of the Liver 1996-1998.

Anna Lok is a Professor of Internal Medicine and Director of Clinical Hepatology at the University of Michigan Medical Center. Her contributions include:?hepatitis B's?role in infection, treatment of hepatitis-induced diseases, development?of?cost-effective methods for preventing recurrent hep B infection following liver transplantation, and long-term effects of interferon treatment in patients with hep C.

Stephen Locarnini's research group is composed of: molecular diagnostics, new drug targets in HBV and molecular pathogenesis. Stephen is also the Director of the World Health Organisation (WHO) Collaborating Centre for Virus Reference and Research at the VIDRL.

List of Contributors, xxx

Preface, xxx

SECTION I: Introduction to liver biology

1 Liver regeneration and fibrosis
Stuart J. Forbes and Malcolm R. Alison

2 Hepatic Immunology
Gyongyi Szabo and Johanna Bruneau

SECTION II: Hepatitis A Virus

3 Structure, molecular virology, natural history and experimental models
Gerardo Kaplan, Krishnamurthy Konduru, Mohanraj Manangeeswaran, Jerome Jacques, Nadia Amharref and Siham Nakamura

4 Epidemiology and prevention
Ben Cowie & Stephen A Locarnini

SECTION III: Hepatitis B virus and other Hepadnaviridae

5 Structure and molecular virology
Souphalone Luangsay and Fabien Zoulim

6 Epidemiology and prevention
Philip R. Spradling, Dale J. Hu and Brian J. McMahon

7 Other Hepadnaviridae (including Avihepadnaviridae and Woodchuck Hepatitis Viruses)
Stephen A Locarnini and Michael Roggendorf

8 Molecular variants of hepatitis B surface antigen (HBsAg)
Seyed Mohammad Jazayeri, Seyed Moayed Alavian, Payam Dindoost, Howard C Thomas and Peter Karayiannis

9 Molecular variants of the precore, core and core promoter regions of hepatitis B virus, and their clinical significance
Peter Karayiannis, William F Carman and Howard C Thomas

10 Natural history of chronic hepatitis B virus infection
Yun-Fan Liaw

11 Extrahepatic manifestations of hepatitis B infection
Christian Trépo, Majid Amiri and Loïc Guillevin

12 Hepatocellular carcinoma: molecular aspects
Marie Annick Buendia and P. Tiollais

13 Murine models and human studies of pathogenesis of chronic hepatitis B
Juandy Jo, Anthony Tanoto Tan and Antonio Bertoletti

14 Treatment of hepatitis B
Hellan K. Kwon and Anna S.F. Lok

15 Liver transplantation for chronic hepatitis B and C
Ed Gane

SECTION IV: Hepatitis C Virus

16 Structure and molecular virology
Michael J McGarvey and Michael Houghton

17 Epidemiology and prevention
Josep Quer and Juan I Esteban Mur

18 The immune response to HCV in acute and chronic Infection
Robert Thimme and Salim I Khakoo

19 Animal models of hepatitis C virus infection
Patrizia Farci and Jens Bukh

20 Extrahepatic manifestations of hepatitis C virus infection
Benjamin Maasoumy, Michael P. Manns and Markus Cornberg

21 Central nervous system complications of hepatitis C virus infection
Daniel M Forton, Simon D Taylor-Robinson, Markus Gess and Howard C Thomas

22 In vitro replication models
Volker Lohmann, Sandra Bühler and Ralf Bartenschlager

23 Natural history of chronic HCV infection and non-invasive assessment of hepatic fibrosis
Laurent Castera

24 Hepatitis C and Hepatocellular Carcinoma
Hubert Blum

25 Treatment of hepatitis C
Christoph Welsch and Stefan Zeuzem

26 Development of anti-HCV drugs
Esperance Schaefer and Raymond Chung

SECTION VI: Hepatitis D Virus

27 Structure and molecular virology
Francesco Negro

28 Epidemiology and natural history
Heiner Wedemeyer, Svenja Hardtke & Michael P. Manns

29 Treatment of hepatitis D
A. Ciancio and Mario Rizzetto

SECTION VII: Hepatitis E Virus

30 Structure and molecular virology
Xiang-Jin Meng

31 Epidemiology, experimental models, prevention and zoonotic aspects
Subrat Kumar Panda, Satya Pavan and Kumar Varma

32 Clinical and pathologic features, diagnosis
Cyril Sieberhagen and Matthew E Cramp

SECTION VII: Clinical Aspects of Viral Liver Disease

33 Clinical and Diagnostic Aspects of Viral Hepatitis
Cui Li Lin, Chelsea Q. Xu and Jack R. Wands

34 Treatment of acute, severe acute hepatitis and fulminant hepatitis/acute liver failure
Hans L. Tillmann and Alastair D Smith

35 Hepatitis and haemophilia
Mike Makris and Geoffrey Dusheiko

36 Hepatitis in persons infected with HIV
Janice Main and Brendan McCarron

37 Migration and hepatitis
Manuel Carballa

38 Occupational aspects of hepatitis
William L Irving and Fortune Ncube

39 Neonatal and paediatric infection
Deirdre Kelly and C. Y. William Tong

40 Management of hepatocellular carcinoma
Massimo Iavarone and Massimo Colombo

41 Application of molecular biology to the diagnosis of viral hepatitis
Stéphane Chevaliez, Christophe Rodriguez and Jean-Michel Pawlotsky

42 Disinfection and sterilization
Martin S Favero and Walter W Bond

43 Evolution of hepatitis viruses
Peter Simmonds and Donald B. Smith

Index

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