The Wiley Handbook on the Aging Mind and Brain

A thought-provoking treatise on understanding and treating the aging mind and brain

This handbook recognizes the critical issues surrounding mind and brain health by tackling overarching and pragmatic needs so as to better understand these multifaceted issues. This includes summarizing and synthesizing critical evidence, approaches, and strategies from multidisciplinary research—all of which have advanced our understanding of the neural substrates of attention, perception, memory, language, decision-making, motor behavior, social cognition, emotion, and other mental functions.

Written by a plethora of health experts from around the world, The Wiley Handbook on the Aging Mind and Brain offers in-depth contributions in 7 sections: Introduction; Methods of Assessment; Brain Functions and Behavior across the Lifespan; Cognition, Behavior and Disease; Optimizing Brain Function in Health and Disease; Forensics, Competence, Legal, Ethics and Policy Issues; and Conclusion and New Directions.

• Geared toward improving the recognition, diagnosis, and treatment of many brain-based disorders that occur in older adults and that cause disability and death
• Seeks to advance the care of patients who have perceptual, cognitive, language, memory, emotional, and many other behavioral symptoms associated with these disorders
• Addresses principles and practice relevant to challenges posed by the US National Academy of Sciences and National Institute of Aging (NIA)
• Presents materials at a scientific level that is appropriate for a wide variety of providers

The Wiley Handbook on the Aging Mind and Brain is an important text for neurologists, psychiatrists, psychologists, physiatrists, geriatricians, nurses, pharmacists, social workers, and other primary caregivers who care for patients in routine and specialty practices as well as students, interns, residents, and fellows.

Matthew Rizzo is the Frances and Edgar Reynolds Professor and Chair of the Department of Neurological Sciences and Chief Physician for Neuroscience Clinical Programs at the University of Nebraska Medical Center.

Steven Anderson is Associate Professor in the Department of Neurology and the Interdisciplinary Graduate Program of Neuroscience at the University of Iowa.

Bernd Fritzsch is an Entrepreneurial Professor at the University of Iowa. He is also Director of the Center on Aging and Director of the Aging Mind and Brain Initiative. 

List of Contributors viii

Acknowledgments xii

List of Abbreviations xiv

Glossary xx

Part I Introduction 1

1 The Aging Mind and Brain: Overview 3
Matthew Rizzo, Steven Anderson, and Bernd Fritzsch

Part II Theoretical, Animal Models, Social, and Humanistic Perspectives 17

2 Social Networks, Social Relationships, and Their Effects on the Aging Mind and Brain 19
Sato Ashida and Ellen J. Schafer

3 Aging and the Brain 37
Veena Prahlad and Madhusudana Rao Chikka

4 Animal Models of Pathological Aging 61
Eric B. Emmons, Youngcho Kim, and Nandakumar S. Narayanan

5 Humanistic Perspectives: Arts and the Aging Mind 78
Andrea Charise and Margaret L. Eginton

Part III Methods of Assessment 101

6 Medical Assessment of the Aging Mind and Brain 103
T. Scott Diesing and Matthew Rizzo

7 Neuropsychological Assessment of Aging Individuals 130
R. D. Jones

8 Normal Aging: Brain Morphologic, Chemical and Physiologic Changes Detected within vivo MRI 146
A. A. Capizzano, T. Moritani, M. Jacob, and David E. Warren

9 Positron Emission Tomography (PET) Imaging: Principles and Potential Role in Understanding Brain Function 164
Laura L. Boles Ponto

10 Electrophysiological Measures of Age-Related Cognitive Impairment In Humans 188
David E. Anderson and Olga Taraschenko

11 The Brain in the Wild: Tracking Human Behavior in Naturalistic Settings 204
Gabriella E. M. Rizzo and Matthew Rizzo

12 Quality of Life Assessment 223
Fredric D. Wolinsky and Elena M. Andresen

Part IV Brain Functions and Behavior Across the Lifespan 253

13 Executive Functions and Behavior Across the Lifespan 255
Paul J. Eslinger and Claire Flaherty

14 Memory and Language in Aging: How Their Shared Cognitive Processes, Neural Correlates, and Supporting Mechanisms Change with Age 270
David E. Warren, Rachael Rubin, Samantha Shune, and Melissa C. Duff

15 Vision and Aging 296
Cynthia Owsley, Deepta Ghate, and Sachin Kedar

16 Aging-Related Balance Impairment and Hearing Loss 315
Deema Fattal, Marlan Hansen, and Bernd Fritzsch

17 Attention and Processing Speed 337
Benjamin D. Lester, Daniel B. Vatterott, and Shaun P. Vecera

18 Motor Functions and Mobility 362
Warren G. Darling, Kelly J. Cole, and James A. Ashton-Miller

19 Incontinence and Sexual Dysfunction 389
Karl J. Kreder, Sarah Fraumann Faris, Matthew Rizzo, and Satish S-C. Rao

20 Emotional Function During Aging 417
Kuan-Hua Chen and Steven W. Anderson

Part V Brain Disease and Dysfunction 445

21 Alzheimer’s Disease and Mild Cognitive Impairment 447
David T. Jones, Marla B. Bruns, and Ronald C. Petersen

22 Cerebrovascular Disease and White Matter Disorders 483
Nandakumar Nagaraja and Enrique C. Leira

23 Movement Disorders 523
Dronacharya Lamichhane and Ergun Y. Uc

24 Psychiatric Disorders 541
Steven P. Wengel, Roberto F. Cervantes, and William J. Burke

25 Encephalopathy 553
Alberto Serrano-Pozo

26 Traumatic Brain Injury and Neurodegenerative Disease 591
Dawn McGuire

27 Sleep and Sleep Disorders in Older Adults 619
Jon Tippin

28 PAIN 628
Keela Herr, Stephen Gibson, and Thomas Hadjistavropoulos

Part VI Optimizing Brain Function in Health and Disease 649

29 The Benefits of Physical Activity on Brain Structure and Function in Healthy Aging and Age-Related Neurological Disease 651
Michelle W. Voss

30 Aging, Mind and Brain: A Human Factors Engineering Perspective 662
Sara J. Czaja

31 Community and Long-Term Care Supports for Older Adults with Cognitive Decline 673
Kristine Williams and Ying-Ling Jao

Part VII Legal and Ethical Issues 687

32 Neuroethics of Aging 689
Steven Anderson

33 The Public Health Challenge Presented by the Growing Population of Persons with Alzheimer’s Disease and Other Forms of Dementia: A Survey of American Public Policy Activity 702
Brian P. Kaskie and Christopher Stamy

34 Competency and Capacity in the Aging Adult 723
Joseph Barrash

35 Boomers After the Bust: Ageism and Employment Discrimination Trends After the Great Recession 742
Helen D. (Heidi) Reavis and Alison Roh Park

Part VIII Conclusion 761

36 Science, Society, and a Vision for Mind and Brain Health Across the Lifespan 763
Matthew Rizzo, Steven Anderson, and Bernd Fritzsch

Index 769

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