Reflections on a Century of Malaria

Malaria is one of the most common infectious diseases and an enormous public health problem. Each year it causes disease in approximately 650 million people and kills between one and three million, most of them young children in Sub-Saharan Africa. This book provides an overview of the research that has been done in malaria biochemistry in the quest to find a cure. It discusses how our understanding has helped us to develop better diagnostics and novel chemotherapies. Researchers will find having all of this information in one volume, annotated with personal reflections from a leader in the field, invaluable given the big push being made on various fronts to use the latest drug discovery tools to attack malaria and other developing country diseases. * Reviews the past 100 years of malaria biochemistry research providing researchers with an overview of the investigations that have been undertaken in this field Benefit: Allows researchers to see what progress has been made so that they can use this knowledge when trying to develop the latest drug discovery tools to attack malaria * Chronicles both biochemical successes and failures Benefit: Allows researchers to see what has and hasn?t work which they can then apply in their own research

Contributor	p. vii
Introduction	p. 1
An Introduction to Malaria Parasites	p. 3
The Early Years	p. 9
Show Me the Money	p. 15
In Vivo and In Vitro Models	p. 27
Life in the Erythrocyte	p. 27
Life Outside the Erythrocyte	p. 32
Life in the Mosquito	p. 37
Malaria Pigment	p. 49
Chloroquine and Haemozoin	p. 59
Isoenzymes	p. 63
The Road to the Plasmodium falciparum Genome	p. 73
Carbohydrate Metabolism	p. 85
Glycolysis and the Tricarboxylic Acid Cycle	p. 85
The Pentose Phosphate Pathway	p. 89
Pyridine Nucleotides	p. 89
Carbon Dioxide Fixation	p. 90
Pyrimidines and the Mitochondrion	p. 93
The Road to Atovaquone	p. 101
The Ring Road to the Apicoplast	p. 105
Ribosomes and Ribosomal Ribonucleic Acid Synthesis	p. 113
De Novo Synthesis of Pyrimidines and Folates	p. 119
Salvage of Purines	p. 141
Polyamines	p. 149
New Permeability Pathways and Transport	p. 153
Haemoglobinases	p. 173
Erythrocyte Surface Membrane Proteins	p. 183
The Road to PfeMP1	p. 183
PfeMP1, Knobs and Adhesion	p. 192
PfeMP1 and Rosetting	p. 196
PfeMP1 and Placental Adhesion	p. 198
Knob-Associated Proteins Involved with Adhesion	p. 199
Band 3 and Adhision	p. 201
Adhesion and Cerebral Malaria	p. 204
Trafficking	p. 209
Erythrocyte Membrane Lipids	p. 217
Invasion of Erythrocytes	p. 231
Vitamins and Anti-Oxidant Defences	p. 255
Vitamin B[subscript 1] (Thiamin)	p. 256
Vitamin B[subscript 6]	p. 257
Pantothenate	p. 259
Biotin (Vitamin B[subscript 7])	p. 260
Vitamin B[subscript 3] (Niacin)	p. 260
p-Aminobenzoic Acid	p. 261
Riboflavin	p. 262
Vitamins A, C, D and E	p. 263
Anti-Oxidant Defences	p. 264
Shocks and Clocks	p. 273
Transcriptomes, Proteomes and Data Mining	p. 283
Transcriptomes	p. 284
Proteomes	p. 293
Data Mining	p. 297
Mosquito Interactions	p. 301
Sexual Stages in the Blood	p. 301
Gametogenesis and Ookinete Formation	p. 303
Oocyst and Sporozoite Formation	p. 314
Journey to the Liver	p. 318
References	p. 325
Index	p. 395
Contents of Volumes in This Series	p. 403
Table of Contents provided by Ingram. All Rights Reserved.

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Reflections on a Century of Malaria Biochemistry

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