Handbook of Reward and Decision Making

This book presents the most recent and compelling neuroimaging, electrophysiological, behavioral and pharmacological techniques, in combiination with molecular and genetic tools, which have led to a clearer understanding of neural mechanisms behind reward and decision making. Armed with this understanding, neuroscientists will be able to develop new pharmacological and nonpharmacological therapies to improve cognitive function in patients with neurological and psychiatric disorders (e.g., schizophrenia, Parkinson's, substance abuse, pathological gambling). * Offers most current evidence of neural mechanisms underlying decision making from studies on animal and human subjects * Presents latest functional MRI studies that provide insights into specific cognitive processes and how the brain makes decisions when facing multiple options * Explains impaired reward processing and clinical implications in human disease states (addiction, schizophrenia, Parkinson's Disease)

Preface	p. ix
List of contributors	p. xiii
Monkey Anatomical and Electrophysiological Studies on Reward and Decision making	p. 1
Anatomy and connectivity of the reward circuit	p. 3
Electrophysiological correlates of reward processing in dopamine neurons	p. 29
The ventral striatum: a heterogeneous structure involved in reward processing, motivation and decision-making	p. 51
Role of the primate lateral prefrontal cortex in integrating decision-making and motivational information	p. 79
From reward value to decision-making: neuronal and computational principles	p. 97
fMRI Studies on Reward and Decision Making	p. 135
Decomposing brain signals involved in value-based decision making	p. 137
Reward processing in the human brain: insights from fMRI	p. 165
Spatiotemporal characteristics of perceptual decision making in the human brain	p. 185
Feedback valuation processing within the prefrontal cortex	p. 213
Computational neuroimaging: monitoring reward learning with blood flow	p. 229
Brain Disorders Involving Dysfunctions of Reward and Decision Making Processes	p. 249
Can models of reinforcement learning help us to understand symptoms of schizophrenia?	p. 251
Effects of dopamine depletion on reward-seeking behavior: evidence from human and non-human primates	p. 271
A neuropsychological perspective on the role of the prefrontal cortex in reward processing and decision-making	p. 291
Genetic and Hormonal Influences on the Reward System	p. 307
Gonadal steroid hormones' influence on reward and decision making processes	p. 309
Hormone effects on specific motivational states and underlying CNS arousal	p. 335
The genetic basis of individual differences in reward processing and the link to addictive behavior	p. 345
Catechol-O-methyltransferase (COMT) genotype effects on brain activation elicited by affective stimuli and cognitive tasks	p. 361
Computational Models of the Reward System and Decision Making	p. 373
Optimal decision-making theories	p. 375
The basal ganglia in reward and decision making: computational models and empirical studies	p. 399
Reward-based emotions: affective evaluation of outcomes and regret learning	p. 427
Bayesian decision making in two-alternative forced choices	p. 441
Predicting risk in a multiple stimulus-reward environment	p. 459
Index	p. 475
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Handbook of Reward and Decision Making

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Handbook of Reward and Decision Making

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