The Lure of Bacterial Genetics

John Roth has had a long and very productive career in bacterial genetics and has influenced many in the field through his teaching and research. On the occasion of his 70th birthday, and in the year in which he is to receive the prestigious Thomas Hunt Morgan Award from the Genetics Society of America, a number of his students and colleagues have assembled a collection of essays in bacterial genetics in his honor. These essays are designed to be interesting reading for all those working in or interested in bacterial genetics, and they examine topics in some of the areas in which John Roth has worked, including gene expression and regulation; physiology and metabolism; chromosomes, genomes and evolution; and applications of microbial genetics to such things as antibiotic resistance and the quest for new vaccines.

Contributors	p. ix
Preface	p. xiii
Introduction	p. 1
John Roth's Paths and Pathways	p. 3
Giving a Seminar: Suggestions for Graduate Students	p. 9
Phage and Bacterial Genetics at Cold Spring Harbor Laboratory	p. 23
Reflections of a Beer Auxotroph	p. 27
Gene Expression and Genetic Regulation	p. 33
The Biotin Operon of Escherichia coli	p. 35
Why Galactose? The Early Curiosities and the Consequences	p. 43
Control of Gene Expression by Compartmentalization: the put Operon	p. 55
Genetics of the Heme Pathway and Its Regulation	p. 65
Regulation of NAD(P) Metabolism in Salmonella	p. 75
Ethanolamine Utilization in Salmonella	p. 87
Fishing for Fluke: the Genetics of Flk and the Flagellar Type 3 Secretion Specificity Switch	p. 99
tRNA and Suppressors	p. 115
Souvenirs from My Genetic Initiation	p. 117
Complementary Studies in the Histidine Operon and on Frameshifting: a Compliment to What Roth Has Wrought	p. 123
Adventures with Frameshift Suppressor tRNAs	p. 131
Physiology and Metabolism	p. 141
Microbial Channels: Forbidden Fruit from Missense Rather than Nonsense	p. 143
Of Bacteria and Bile	p. 153
Swarming Adventures	p. 163
Using Genetic Approaches To Delineate the Pathway of Contact-Dependent Growth Inhibition	p. 173
Covert Operations: the Adaptable Plan of Attack Deployed by Pathogenic Bacteria	p. 185
Phenotypic Variation and Gene Regulation in the Pathogenesis of Salmonella Infection	p. 201
Genes, Chromosomes, and Rearrangements	p. 209
DNA Methylation and Mismatch Repair	p. 211
Salmonella Genetics	p. 219
Finding Inversions	p. 227
Barriers to the Formation of Inversion Rearrangements in Salmonella	p. 233
Adventures with Mutation and Selection in Beehive and Cow Country	p. 245
Genomes and Evolution	p. 255
From Genetics to Genomics	p. 257
Baltimore and Beyond: from Gene Action to the Postgenomic Era	p. 267
Three Histories of Competence and Transformation	p. 277
A Plethora of Putative Phages and Prophages	p. 291
Impact of Horizontal Genetic Transfer on the Evolution of Bacterial Genomes	p. 307
Germ Line DNA Parasites That Have Converged on an Altruistic Somatic Excision Strategy	p. 325
Recombineering: Advanced-Advanced Bacterial Genetics	p. 333
Epilogue	p. 341
Predicting the Future: a Fish Story	p. 343
Index	p. 349
Table of Contents provided by Ingram. All Rights Reserved.

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The Lure of Bacterial Genetics

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