Cell Survival and Cell Death, Second Edition

In multicellular organisms, cell death is required for normal development, homeostasis, and the elimination of infected or injured cells. The mechanisms by which cell death occurs are genetically encoded and carefully controlled. Perturbations that enhance or suppress cell death may lead to cancer, neurodegeneration, and inflammatory diseases.

Written and edited by experts in the field, this collection from Cold Spring Harbor Perspectives in Biology provides a comprehensive update on the cell signaling that underlies the main cell death programs (apoptosis, pyroptosis, and necroptosis) and how this knowledge is driving the development of therapeutic drugs to treat some human diseases. Contributors describe in detail the molecular mechanisms of cell death signaling and the myriad players involved, including death receptor-ligand systems, BCL-2 family proteins, caspases, inflammasomes, gasdermin, MLKL, RIPK1, A20, and XIAP. They also examine the involvement of cell death programs in various pathologies and the therapeutic potential of inhibiting key pathway components.

Chapters are additionally devoted to cell death signaling mechanisms in plants and lower organisms, as well as the evolution of those mechanisms and the influence of pathogens that seek to evade them. This volume is therefore an essential reference for cell and developmental biologists, cancer biologists, and all who wish to explore recent progress in our understanding of cell death programs.

(preliminary)

BAX, BAK, and BOK; A Coming of Age for the BCL-2 Family Effector Proteins
Tudor Moldoveanu and Peter E. Czabotar

BH3 Mimetics: Targeting Pro-Survival Bcl2 Family Members for the Treatment of Cancer
David Huang and Wayne Fairbrother

Mechanisms of Caspase Activation
Marion Macfarlane

Cracking the Cell Death Code
Carla V. Rothlin and Sourav Ghosh

Phagocyte Responses to Cell Death in Flies
Andrew J. Davidson and Will Wood

Multi-tasking Kinase RIPK1 Regulates Cell Death and Inflammation
Kim Newton

The Killer Pseudokinase MLKL
James M. Murphy

Targeting Death Receptors in Cancer and Inflammation
Henning Walczak

Recent Insights on Inflammasomes, Gasderin Pores, and Pyroptosis
Nathalia M. de Vasconcelos and Mohamed Lamkanfi

Mechanism and Regulation of Gasdermin-Mediated Cell Death
Shiyu Xia, Louis Robert Hollingsworth IV, and Hao Wu

A20 at the Crossroads of Cell Death, Inflammation, and Autoimmunity
Arne Martens and Geert van Loo

Regulation of Cell Death and Immunity by XIAP
Philipp J. Jost and Domagoj Vucic

Cell Death and Neurodegeneration
Benjamin J. Andreone, Martin Larhammar, and Joseph W. Lewcock

Evolution of the Cell Death Machinery
Kay Hofmann

Programmed Cell Death in the Evolutionary Race Against Bacterial Virulence Factors
Carolyn A. Lacey and Edward A. Miao

How Viral Pathogens Subvert the Cell Death Machinery
Bill Kaiser

Cell Cycle Crosstalk with Caspases and Their Substrates
Patrick Connolly, Irmina García-Carpio, and Andreas Villunger

The Hypersensitive Response Cell Death in Plant Immunity
Eugenia Pitsii, Ujjal J. Phukan, and Núria S. Coll

Dysregulation of Cell Death in Chronic Human Inflammation
Yue Li, Christoph Klein, and Daniel Kotlarz

Neutrophil Extracellular Traps in Host Defense
Sabrina Sofia Burgener and Kate Schroder