Trends in Drug Research III: Proceedings of

Free Univ. Amsterdam, The Netherlands. Proceedings of the 13th Noordwijkerhout-Camerino Symposium, held in The Netherlands on May 6-11, 2002.

Preface

ix

Towards rational design of AMPA receptor ligands: an integrated medicinal, computational, biostructural and molecular pharmacological approach

1

(12)

A. Hogner

J.S. Kastrup

J. Greenwood

S.B. Vogensen

E.H. Møller

T.B. Stenbøl

J. Egebjerg

P. Krogsgaard-Larsen

From heparin to synthetic antithrombotics. The pentasaccharide story and follow- up

13

(8)

C.C.A van Boeckel

A new future for synthesis?

21

(6)

A. Bruggink

Directed evolution of enantioselective enzymes as catalysts in the production of chiral pharmaceuticals

27

(12)

M.T. Reetz

At the interface of organic synthesis and biosynthesis

39

(14)

R. Schoevaart

A.P.G. Kieboom

What can structure tell us about function in the estrogen receptors?

53

(4)

R.E. Hubbart

Molecular docking and dynamics simulations in the ligand binding domain of steroid hormone receptors

57

(10)

M. Kouwijzer

J. Mestres

Peroxisome proliferator-activated receptors and reverse endocrinology

67

(14)

S. Kliewer

Biomolecular mass spectrometry related to drug research

81

(14)

A.J.R. Heck

C.S. Maier

Chemical and biological diversity in drug discovery

95

(2)

P. Angeli

G. Gaviraghi

Muscarine acetylcholine receptor knockout mice: phenotypical analysis and clinical implications

97

(18)

J. Gomeza

M. Yamada

A. Duttaroy

W. Zhang

R. Makita

T. Miyakawa

J. Crawley

L. Zhang

H. Shannon

F.P. Bymaster

C. C. Felder

C. Deng

J. Wess

Changes in expression of the orphan G-protein coupled receptor GPR7 in human painful peripheral neuropathies

115

(10)

P.F. Zaratin

A. Quattrini

S. Previtali

G. Hervieu

M.A. Scheideler

Computational methods for the analysis of molecular diversity

125

(10)

V.J. Gillet

P. Willett

Enhancing drug discovery by acquisition of chemical diversity

135

(12)

D. Langley

Chemical diversity as a driving force to design and put in practice synthetic strategies leading to combinatorial libraries for lead discovery and lead optimization

147

(14)

P. Seneci

Beyond G proteins: the role of accessory proteins in G protein-coupled receptor signalling

161

(14)

H. Just

E. Stefan

C. Czupalla

B. Nurnberg

Chr. Nanoff

M. Freissmuth

Mechanisms of action of antipsychotic drugs: the role of inverse agonism at the D2 dopamine receptor

175

(6)

Ph.G. Strange

Agonist channeling of α2-adrenoceptor function

181

(12)

K.E.O. Akerman

J. Nasman

T. Holmqvist

J.P. Kukkonen

Antibacterials as wonder drugs and how their effectiveness is being compromised

193

(14)

D. Golemi

L. Maveyraud

J. Haddad

W. Lee

A. Ishiwata

K. Miyashita

L. Mourey

S. Vakulenko

L. Kotra

J. Samama

S. Mobashery

Pseudomonas aeruginosa quorum sensing: a target for antipathogenic drug discovery

207

(6)

E.P. Greenberg

Discovery and development of new anti-bacterial drugs

213

(14)

I. Chopra

L. Hesse

A. O'Neill

Discovery of small molecule insulin mimetics as potential novel antidiabetic agents

227

(10)

B.B. Zhang

Expression databases for pharmaceutical lead optimisation

237

(12)

L.M. Furness

New developments in the pharmacology of cannabinoids

249

(10)

R.G. Pertwee

Author index

259

(2)

Subject index

261

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Trends in Drug Research III: Proceedings of the 13th Noordwijkerhout-Caminero Symposium, the Netherlands, 6-11 May 2001

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Table of Contents

Supplemental Materials