Oxford Textbook of Neurologic and Neuropsychiatric Epidemiology

Neurologic and neuropsychiatric disorders are of great importance to societies and they also raise special considerations in epidemiological research methodology. Not only do neurologic and neuropsychiatric disorders form a major group of disorders associated with ageing populations, but those disorders that occur in earlier life can be associated with severe individual, family, and societal distress and burden. The inter-relationship of syndromes and disorders is a topic of major interest and growing biological insights across psychiatry and neurology. This includes not only overlaps in neurodegenerative syndromes but also those related to other systems such as metabolic, inflammatory, immune and vascular disorders.

Part of the Oxford Textbooks in Clinical Neurology series, the Oxford Textbook of Neurologic and Neuropsychiatric Epidemiology is designed to focus on the overlaps and inter-relationships between neuro-epidemiological disorders, as well as on ways to harmonise large cohort studies to maximise opportunities for determining causes related to rarer disorders. Divided into three main parts, the book covers 1) the principles of neurologic and neuropsychiatric epidemiology; 2) specific neuropsychiatric disorders and their inter-relationships and 3) the implications of neuro-epidemiologic research for patient populations and current medical practice. This comprehensive work serves as an invaluable reference to current neuro-epidemiological methods for neurologists, psychiatrists, and senior trainees in those disciplines, as well as public health practitioners and students with an interest in neurology and neuropsychiatry.

Carol Brayne, Professor of Public Health Medicine and Director of the Cambridge University Department of Public Health, University of Cambridge, Cambridge, United Kingdom,Valery Feigin, Director, National Institute for Stroke and Applied Neuroscience (NISAN), Auckland University of Technology, Auckland, New Zealand,Lenore Launer, Senior Investigator, National Institute on Aging, Bethesda, Maryland, United States of America,Giancarlo Logroscino, Director, Department of Clinical Research in Neurological Diseases, University of Bari, Bari, Italy

Carol Brayne CBE is Professor of Public Health Medicine at the University of Cambridge and Director of the Cambridge Institute of Public Health. Graduating from the Royal Free Hospital School of Medicine at the University of London in 1981, she went on to train in general medicine from 1982-1983. Since then, her work has been focused around longitudinal studies of the neurological health of older people from a public health perspective.
Since joining Cambridge, she has been appointed chair of the Faculty of Public Health, Academic & Research Comittee, CLAHRC theme lead, Special Adivsor to the Royal College of Physicians, fellow of the Academy of Sciences, and co-chair of the Alzherimer's Society Research Strategy Council.
Listed among the highest cited scholars in the world in 2018, Professor Brayne was awarded a CBE for services to public health medicine in the Queen's 2017 Honours.


Professor Valery Feigin is the director of Auckland University of Technology's National Institute for Stroke and Applied Neuroscience (NISAN), associate director of the Centre for Neurocomputation and Brain Study at KEDRI, and affiliate professor of the Department of Global Health at the Institute for Health Metrics and Evaluation at the University of Washington.
A current board member of the World Stroke Organisation, Professor Feigin's work focuses predominantly on stroke, TBI, treatment, and epidemiology. He has authored or co-authored over 600 academic publications, and been cited over 31,000 times, and currently serves as Editor-in-Chief of the journal Neuroepidemiology. Feigin has received numerous awards over his career, including the Bruce Shoenburh International Award and Lecture in Neuropepidemiology, the Fogarty International Centre Research Grant Award, and the World Stroke Organization President's award for his services to stroke research.


Dr. Launer is a senior investigator at the National Institute on Aging in Bethesda, Maryland. In 1987, she received her PhD in Epidemiology and Nutrition from Cornell University, after which she undertook a three year post-doctoral fellowship at NICHD. She has held positions at the National Insitute of Health and the Environment and Erasmus University, where she led and was involved with numerous large-scale epidemiological studies into dementia and migraine. Since 1999, she has led the Neuroepidemiology section of the NIA Laboratory of Epidemiology, Demography, and Biometry, where she has researched the genetic, inflammatory, vascular, metabolic, and hormonal factors of sub-clinical and clinical outcomes in brain disease.


Giancarlo Logroscino, MD PhD is Professor of Neurology and director of the Neurodegenerative Diseases Unit at The University of Bari, and Chair of the Department of Clinical Research in Neurology at Pia Fondazione Panico in Tricase (LE). His primary research interests are natural history of neurodegenerative diseases and environmental risk factors for neurodegenerative diseases related to aging.
He has been President of the Neuroepidemiological Italian Association (NEP), a member of the steering committee of the Italian Neurological Association (SIN), and Convenor for the Neuroepidemiology Section of the last meetings (Wien, Austria 2013) (Santiago, Chile 2015) of the World Federation of Neurology Congress.
With more than 300 papers included in journals such as BMJ, JAMA, Lancet, Lancet Neurology, Annals of Neurology, Neurology and Brain, he is associate editor of the journal Neuroepidemiology, Karger, and Basel.

1. A historical perspective on neurological and neuropsychiatric definitions, German E. Berrios and Ivana S. Markov?
2. Neuroimaging and fluid biomarkers of Alzheimer s disease: implications for definition, diagnosis and treatment, V.R. Varma, Y. F. Chuang, and M. Thambisetty
3. Life course, exposure, and ageing populations, Yoav Ben-Shlomo
4. Examining trends in dementia incidence and prevalence using an age-period-cohort framework, Kenneth M. Langa, Eileen Crimmins, and Mark D. Hayward
5. Overview of common designs, measures of effect, and biases in neuro-epidemiological studies, Derrick A. Bennett
6. Conducting research in low and middle income settings., Ma?lenn Guerchet, Rosie Mayston, and A. Matthew Prina
7. Trial designs including observational to interventional, Edo Richard
8. Cardiometabolic morbidities and dementia, Chengxuan Qiu, Davide Liborio Vetrano, and Laura Fratiglioni
9. Early onset Alzheimer s disease, Ratnavalli Ellajosyula
10. Huntington s Disease, Juliana R. Dutra
11. Idiopathic Parkinson s disease and classification of Parkinsonisms, Valentina Gallo, Tanya P. Garcia, and Karen Marder
12. Dementia and Parkinson s disease, Rodolfo Savica and Pierpaolo Turcano
13. FTD and ALS, Giancarlo Logroscino and Adriano Chi?
14. Rare Neurodegenerative Parkinsonism (PSP, MSA, CBD), James B. Rowe and Ian T.S. Coyle-Gilchrist
15. Posterior Cortical Atrophy, Keir X. X. Yong, S. J. Crutch, and J. M. Schott
16. Epidemiology of essential tremor, Elan D. Louis
17. Detecting dementia early in populations, Amy R. Borenstein
18. The oldest-old and dementia at the end of life, Mar?a M. Corrada and Claudia H. Kawas
19. Global stroke burden and prevention strategies- findings from GBD 2015, Rita V. Krishnamurthy and Valery L. Feigin
20. Stroke and TIA, Bo Norrving, MD, PhD
21. Small vessel disease, Fergus Doubal, Anna Poggesi, Leonardo Pantoni, and Joanna Wardlaw
22. Migraine: Descriptive epidemiology and related neurobiology, Julio R. Vieira and Richard B. Lipton
23. The clinical spectrum of neurodegenerative disease: moving beyond Mild Cognitive Impairment, Stina Saunders, Graciela Muniz-Terrera , Tom C. Russ, Craig W. Ritchie, and Karen Ritchie
24. The epidemiology of apathy in neurological disorders, Sergio Starkstein, Bradleigh Hayhow, and Pierre Wibawa
25. Behavioural and Psychological Symptoms of Dementia, Rianne van der Linde and Tom Dening
26. Delirium, Daniel Davis, Sarah Richardson, and Esteban Sepulveda
27. Methods and approaches to examining the interface of late-life depression and dementia, Mirjam I. Geerlings
28. Epidemiology of schizophrenia and related disorders, Assen Jablensky, H. E. Jongsma HE, James B. Kirkbride, and Peter B. Jones
29. Multiple sclerosis: Descriptive epidemiology and related neurobiology, Elisabeth Gulowsen Celius
30. Myasthenia gravis, Anne Taraldsen Heldal and Nils Erik Gilhus
31. Epilepsy, Ettore Beghi, Giorgia Giussani, and Torbjorn Tomson
32. Neuropathies: Descriptive epidemiology and related neurobiology, Ettore Beghi, Giorgia Giussani, and Marco Poloni
33. Sensory loss Vision, Paul J. Foster, Anthony Khawaja, Lisanne J. Balk, Zaynah Muthy, and Axel Petzold
34. Sensory loss - Hearing, Adele M. Goman and Frank R. Lin
35. The Neuroepidemiology of Human Prion Disease, Patrick J. M. Urwin and Anna M. Molesworth
36. Epidemiology of bacterial and parasitic infections of the central nervous system, Charles R. Newton
37. Infection: other than bacterial, including HIV, In?s Yoro-Zohoun, Jaime Luna, Salmane Amidou, and Pierre-Marie Preux
38. Traumatic brain and spinal cord injury, Alice Theadom and Kelly M. Jones
39. Electromagnetic fields, Joachim Sch?z and Maria Feychting
40. Metals and neurodegeneration, Susan Peters, Anne E. Visser, Marc Weisskopf, Marianthi-Anna Kioumourtzoglou, and Roel Vermeulen
41. Estimating the global burden of stroke: methods and challenges, Thomas Truelsen, Catherine Johnson, Mohsen Naghavi, Theo Vos, Valery L. Feigin, and Gregory Roth
42. What is the role of trials and other well designed studies in the understanding of neurological and neuropsychiatric conditions, Carol Brayne
43. Research and methodologic opportunities and challenges conducting research among U.S military personnel, Ann I. Scher, David W. Niebuhr, and Darrell Singer
44. Global evidence generation, Adesola Ogunniyi
45. The role of prevention in common neurological disorders, Giancarlo Logroscino, Carol Brayne, and Rosanna Tortelli