The Biology of Heart Disease

The heart is the first organ to form in a developing embryo, and all subsequent life processes depend on its proper function. But a range of genetic and environmental factors can lead to its failure. Inherited mutations give rise to congenital heart disease, the most common birth defect, and abnormalities of the adult heart are a leading cause of illness and death in industrialized countries.

Written and edited by experts in the field, this collection from Cold Spring Harbor Perspectives in Medicine describes how recent advances in genetics, stem cell biology, and developmental biology are transforming the way we understand and treat heart disease. Contributors review the various cell lineages and molecular networks involved in heart development; the genetic basis of inherited cardiac conditions such as congenital heart disease, cardiomyopathies, and aortic aneurysm; and how various cutting-edge technologies and models are being employed to study heart biology, uncover disease-related processes, and identify therapeutic targets. Topics include tissue engineering, genome editing, stem cells, cardiomyocyte reprogramming, chemically modified RNA, and next-generation DNA sequencing.

The authors also consider the process of drug discovery and development, and the potential for patient-specific treatments and therapies. This volume is a valuable reference for cardiologists, geneticists, and cell and developmental biologists interested in this complex, vital organ and the future of cardiovascular medicine.

Preface

Cardiac Cell Lineages that Form the Heart
Sigolène M. Meilhac, Fabienne Lescroart, Cédric Blanpain, and
Margaret E. Buckingham

Heart Fields and Cardiac Morphogenesis
Robert G. Kelly, Margaret E. Buckingham, and Antoon F. Moorman

Genetic Networks Governing Heart Development
Ashley J. Waardenberg, Mirana Ramialison, Romaric Bouveret, and Richard P. Harvey

Embryonic Heart Progenitors and Cardiogenesis
Thomas Brade, Luna S. Pane, Alessandra Moretti, Kenneth R. Chien, and Karl-Ludwig Laugwitz

Next Generation Models of Human Cardiogenesis via Genome Editing
Xiaojun Lian, Jiejia Xu, Jinsong Li, and Kenneth R. Chien

How to Make a Heart Valve: From Embryonic Development to Bioengineering of Living Valve Substitutes
Donal MacGrogan, Guillermo Luxán, Anita Driessen-Mol, Carlijn Bouten, Frank Baaijens, and José Luis de la Pompa

Insights into the Genetic Structure of Congenital Heart Disease from Human and Murine Studies on Monogenic Disorders
Terence Prendiville, Patrick Y. Jay, and William T. Pu

Complex Genetics and the Etiology of Human Congenital Heart Disease
Bruce D. Gelb and Wendy K. Chung

Genetics and Disease of Ventricular Muscle
Diane Fatkin, Christine E. Seidman, and J. G. Seidman

The Genetic Basis of Aortic Aneurysm
Mark E. Lindsay and Harry C. Dietz

Model Systems for Cardiovascular Regenerative Biology
Jessica C. Garbern, Christine L. Mummery, and Richard T. Lee

Pluripotent Stem Cell Models of Human Heart Disease
Alessandra Moretti, Karl-Ludwig Laugwitz, Tatjana Dorn, Daniel Sinnecker, and Christine Mummery

Synthetic Chemically Modified mRNA (modRNA): Toward a New Technology Platform for Cardiovascular Biology and Medicine
Kenneth R. Chien, Lior Zangi, and Kathy O. Lui

Direct Cardiomyocyte Reprogramming: A New Direction for Cardivascular Regenerative Medicine
B. Alexander Yi, Christine L. Mummery, and Kenneth R. Chien

Personalized Genomes and Cardiovascular Disease
Kiran Musunuru

Myocardial Tissue Engineering: In Vitro Models
Gordana Vunjak Novakovic, Thomas Eschenhagen, and Christine Mummery

Regenerative Medicine: Transforming the Drug Discovery and Development Paradigm
Sotirios K. Karathanasis

Cardiovascular Drug Discovery: A Perspective from a Research-Based Pharmaceutical Company
G. Gromo, J. Mann, and J. D. Fitzgerald

Human, Human, and Human: A New Century for the Biology of Heart Disease
Kenneth R. Chien

Index