Oxford Textbook of Respiratory Critical Care

Respiratory critical care is essential to modern critical care medicine. To successfully support critically ill patients, an understanding of specific lung conditions and syndromes, their pathophysiological basis, and evidence-based management strategies is of vital importance. The Oxford Textbook of Respiratory Critical Care provides an authoritative account of respiratory critical care medicine with a clear focus on how to manage respiratory disease in the critically ill.

The fundamentals of pathophysiology, diagnosis, and treatment, for respiratory diseases and conditions are outlined with a specific focus on management in the critical care setting. Across 66 chapters, common and unusual respiratory conditions are included as well as those aspects of pulmonary disease in which the management in critical illness is unique. The text equips the reader with up-to-date knowledge of clinical practice for the respiratory system, lung diseases within critical care medicine and the impact of critical illness on lung biology.

Each chapter highlights advances in the field as well as emphasising the importance of getting the basics right. Key messages, controversies, and directions to further research points allow both focused reading and deeper engagement. A dedicated chapter to COVID-19, and sections throughout explore the impact of this novel virus in specific areas of respiratory critical care.

Edited and written by an international group of recognized experts from many disciplines, this essential textbook is relevant to medics globally. This is an indispensable guide for clinicians, researchers and nurses working in Critical Care, Anaesthesia, Respiratory Medicine, Acute Medicine, and Emergency Medicine.

Suveer Singh, Consultant Respiratory and Intensive Care Physician; Professor of Practice, Royal Brompton Hospital, Chelsea & Westminster Hospital; Imperial College London, UK,Paolo Pelosi, Full professor in Anesthesiology and Critical Care;, Department of Surgical Sciences and Integrated Diagnostics, University of Genoa; San Martino Policlinico Hospital, IRCCS for Oncology and Neuosciences, Genoa, Italy,Andrew Conway Morris, Division of Anaesthesia, Department of Medicine, University of Cambridge and Division of Immunology, Department of Pathology, University of Cambridge; JVF Intensive Care Unit, Addenbrooke's Hospital, Cambridge

Dr Singh's academic career combines full time clinical work, with high educational and research output, within Respiratory and Critical Care Medicine. He works in one of the UK's national ECMO centres, leading the follow up service, and in Burns-General ICU. His Grant funded collaborative research is in early diagnostic markers for Ventilator associated pneumonia, behavioural aspects of antibiotic stewardship, safe practice of bronchoscopy in ICU, and Burns inhalation injury. He supervises MD, PhD, MSc, BSc students. He was Imperial College Campus Director of Undergraduate Studies, and is Examiner to the Royal College of Physicians, Faculty of Intensive Care Medicine, European Society of Intensive Care.

Paolo Pelosi: Full Professor in Anaesthesiology and Critical Care, University of Genoa, Genoa, Italy.
Director of Anaesthesia and Critical Care, San Martino Policlinico Hospital, IRCCS for Oncology and Neurosciences, Genoa, Italy. Director of Regional Poison Control Center, San Martino Policlinico Hospital, IRCCS for Oncology and Neurosciences, Genoa, Italy. Fellow of the European Respiratory Society (FERS). Fellow of the Brasilian Academy of Medical Sciences.

Dr Conway Morris undertook his undergraduate training at the University of Glasgow before moving to Edinburgh to train in anaesthesia and intensive care medicine. He completed a PhD at the University of Edinburgh on the function of neutrophils in critical illness, during which time he identified factors which pre-dispose patients to nosocomial pneumonia as well as developing several diagnostics for pneumonia. He moved to the University of Cambridge to continue post-doctoral studies. He is currently an MRC Clinician Scientist Fellow pursuing his research in critical illness immunology and pneumonia, alongside working as a consultant in intensive care medicine in Addenbrooke's Hospital.

Part 1 Basic concepts - lung and critical care
1. History of Mechanical Ventilation, Mark Griffiths, Mary White, and Nirmala Chakkalakal
2. The Respiratory System, Richard Leach
3. Gas Exchange, Andrew Cumpstey and Mike Grocott
4. Airway Defences, Thomas S. Wilkinson
Part 2 The Critical Care Unit
5. Organisation, Judit Orosz and Steve McGoughlin
6. Emergency Planning and Disaster Management, Richard Keays
Part 3 Non-invasive Ventilation
7. High Flow Nasal Oxygen Therapy, Federico Longhini, Paolo Navalesi, Mariachiara Ippolito, and Cesare Gregoretti
8. Non invasive Ventilation in Critical Care, Cesare Gregoretti, Andrea Cortegiani, Vincenzo Russotto, and Lara Pisani
9. Clinical applications of Non invasive ventilation in Critical Care, Federico Longhini, Rosanna Vaschetto, and Paolo Navalesi
10. Medical Gases and Humidification, Lorenzo Ball, Francesco Tasso, Veronica Vercesi, Marco Tixi, Iacopo Firpo, and Paolo Pelosi
Part 4 Basic Concepts in Positive Pressure Ventilation
11. Mechanical Ventilation: how to set up the ventilator, Christoph Boesing, Thomas Luecke, and Joerg Krebs
12. Pulmonary effects of Positive Pressure Ventilation, Pedro Leme Silva, Gary Nieman, Paolo Pelosi, and Patricia RM Rocco
13. Extrapulmonary effects of Positive pressure Ventilation, Pedro Leme Silva, Gary Nieman, Paolo Pelosi, and Patricia RM Rocco
Part 5 Monitoring the Mechanically Ventilated Patient
14. Monitoring airway inflammation and infection, Anthony Rostron, Thomas Hellyer, and A John Simpson
15. Monitoring lung protective ventilation, Paolo Formenti and John J Marini
16. Monitoring Respiratory muscle function, Benjamin Garfield and Sunil Patel
17. Monitoring Cardiovascular function in Critically Ill patients, Rodney A Gabriel and Michael R Pinksy
18. Imaging Critically Ill patients, Arjun Nair
19. Bronchoscopy in Critical Care, Suveer Singh
Part 6 Advanced Mechanical Ventilation
20. Airway Management, Johannes M Huitink and Lorenz G Theiler
21. Acute Respiratory Distress Syndrome, Michele Umbrello, Paolo Formenti, and Davide Chiumello
22. Advanced Respiratory Therapies: Inhaled therapies, Heliox, ECMO and ECCO2-R, Non conventional ventilatory modes, Stephan Ehrmann, Nicole P. Juffermans, Marcus J. Schultz, Nicolò Patroniti, Alex Molin, Martin Scharffenberg, Sabine Nabecker, and Marcelo Gama de Abreu
Part 7 Care of the ventilated patient
23. Thromboprophylaxis, Emma Louise Hartley and Andrew Retter
24. Fluid Balance, Hollmann D. Aya and Maurizio Cecconi
25. Sedation, Analgesia, and Paralysis, Yahya Shehabi and Maja M. Green
26. Nutrition, Danielle E Bear and Zudin Puthucheary
27. Gastric Protection, Mette Krag, Morten Hylander Møller, Suveer Singh, and Matt P Wise
28. Mucus and Bronchopulmonary clearance, Susannah Leaver and Jonathan Ball
29. Delirium and Sleep, Ahmed Al-Hindawi, Eli Rogers, and Marcela P. Vizcaychipi
30. Physiotherapy, Bronwen Connolly and Paul Twose
31. Human Factors and End of Life, Christopher D Hingston
Part 8 Respiratory Infections
32. Ventilator associated pneumonia, Vimal Grover and Suveer Singh
33. Bacterial Pneumonia, David R. Woods and Ricardo J. José
34. Viral Pneumonias, Jordi Rello, Eleonora Bunsow, and Leonel Lagunes
35. COVID-19 in the intensive care unit: Epidemiology, Pathophysiology, Respiratory management, Haemodynamic support, Renal support, Pharmacological treatments and Superinfection, Jonathon P. Fanning, Gianluigi Li Bassi, Patricia Rieken Macedo Rocco, Lorenzo Ball, Antonio Messina, Marlies Ostermann, Matteo Bassetti, and Daniele Roberto Giacobbe
36. Pleural infection, Loïc Lang-Lazdunski
37. Fungal respiratory Infections, Matteo Bassetti, Alessia Carnelutti, and Elda Righi
38. Mycobacterial Infections, Christopher M. Orton, Hannah Jarvis, and Onn Min Kon
39. Traveller's Pneumonia, Dhruva Chaudhry, Pawan Kumar Singh, and Manjunath B. Govindagoudar
40. Pharmacology of anti infective drugs in critical illness, Vanya Gant
Part 9 Critical Care management of Pulmonary Diseases and other Respiratory manifestations
41. Chronic obstructive pulmonary disease, Andrea Carsetti and Simone Bazzurro
42. Asthma, Mara Ricci, Giovanni Carmine Iovino, Lucrezia Mincione, Ivan Dell'atti, and Salvatore Maurizio Maggiore
43. Thromboembolic disease, Caroline Patterson and Derek Bell
44. Pulmonary Haemorrhage, Vasilis Kouranos
45. Pulmonary Hypertension and Cor Pulmonale, Laura C Price, S John Wort, and Simon J Finney
46. Organising Pneumonia, Peter M George, Suveer Singh, and Felix Chua
47. Interstitial Lung disease, Philip Molyneux and Athol U Wells
48. The Haematological patient, Nilima Parry-Jones, Jack Parry-Jones, and Matt P Wise
49. Oncological aspects of respiratory critical care, Hemang Yadav, Alastair C Carr, and Philippe R Bauer
50. Sickle cell disease, Muriel Fartoukh, Guillaume Voiriot, Aude Gibelin, Julien Lopinto, Armand Mekontso-Dessap
51. Neuromuscular disease, Michael I Polkey
52. Pleural Disease, Fraser Brims and Edward TH Fysh
53. Chest wall disease and Post thoracic surgery, Thomas Kiss and Marcelo Gama de Abreu
54. Obesity, Audrey de Jong and Samir Jaber
55. Trauma, Timothy Scott and Christopher M R Satur
56. Pneumothorax and Air Leaks, Giorgio della Rocca and Luigi Vetrugno
57. The Obstetric patient, Timothy Crozier
58. Transfusion, Markus Honickel, Oliver Grottke, and Rolf Rossaint
59. Anaphylaxis, Jasmeet Soar, Fiona Moghaddas, and Stephen M. Robinson
60. Aspiration and Drowning, Simone Bazurro, Andrea Carsetti, and Greg McAnulty
61. Burns and Inhalation Injury, Sabri Soussi, Matthieu Legrand, and Suveer Singh
62. Poisoning, Omender Singh, Suneel Kumar Garg, and Deven Juneja
63. Lung Transplantation, Thomas Bein and Michael Pfeifer
Part 10 Weaning and Long-term ventilation
64. Liberation from Mechanical Ventilation, Patrick B Murphy, Andrew Jones, and Luigi Camporota
65. Home Mechanical Ventilation, Rachel d'Oliveiro and Michael Davies