Methods in Neurosciences Vol. 21 : Providing Pharmacological Access to the Brain, Alternate Approaches

, by Flanagan, Thomas R.; Emerich, Dwaine F.; Winn, Shelley R.

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ISBN: 9780121852917 | 0121852911
Cover: Hardcover
Copyright: 9/1/1994

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This volume focuses on contemporary approaches for delivering experimental and therapeutic agents into the brain. The contributions provide methodological details that are typically not available in the literature. Subtleties and shortcuts critical to each procedure are included to facilitate their use by both the experienced researcher and novice. Highlights * Polymeric, cellular, and molecular drug delivery * Neuropharmacology * Blood-brain barrier * Central nervous system

Characterizing the Blood-Brain Barrier
Cellular Response of Central Nervous System Tissue to Invasive Therapeutic Measures
Models of Angiogenesis and the Blood-Brain Barrier
Transiently Removing the Blood-Brain Barrier
Osmotic Opening of the Blood-Brain Barrier and Brain Tumor Chemotherapy
Osmotic Blood-Brain Barrier Modification: Increasing Delivery of Diagnostic and Therapeutic Agents to the Brain
Facilitated Transport through the Blood-Brain Barrier
Peripheral Administration of Nerve Growth Factor Conjugated to an Anti-transferrin Receptor Antibody Increases Cholinergic Neuron Survival in Intraocular Forebrain Transplants
Ferrotransferrin and Antibody against the Transferrin Receptor as Potential Vehicles for Drug Delivery across the Mammalian Blood-Brain-Barrier into the Central Nervous System
Depofoam-Mediated Drug Delivery into Cerebrospinal Fluid
Polymeric Release Systems for the Central Nervous System
Interstitial Drug Delivery to the Central Nervous System Using Controlled Release Polymers: Chemotherapy for Brain Tumors
Sustained Intracerebral Delivery of Nerve Growth Factor with Biodegradable Polymer Microspheres
Polymeric Drug Carrier Systems in the Brain
Using Pump Delivery Devices within the Brain
Using Osmotic Minipumps for Intracranial Delivery of Amino Acids and Peptides
Continuous Central Nervous System Infusion with Alzet Osmotic Pumps
Injection of Biologically Active Substances into the Brain
Using Implanted Living Tissues within the Brain
Factors Important in the Survival of Dopamine Neurons in Intracerebral Grafts of Embryonic Substantia Nigra
Techniques in Adrenal Medullary Transplantation for Experimental Nonhuman Primate Parkinsonism
Technical Aspects of Transplantation of the Adrenal Medulla to the Caudate Nucleus as a Treatment for Parkinsons Disease
Creating Cell Lines for Transplant Therapies
Transplantation of Epidermal Growth Factor-Responsive Neural Stem Cell Progeny into the Murine Central Nervous System
Application of Astrocyte Transplants as a Therapeutic Intervention
Development of Immortalized Cell Lines for Transplantation in Central Nervous System Injury and Degeneration Models
Using Implanted Living Cells within the Central Nervous System
Use of Genetically Modified Cells to Deliver Neurotrophic Factors and Neurotransmitters to the Brain
Neuropeptide and Catecholamine Delivery to the Central Nervous System by Implanted Chromaffin Cells
Using Implanted Encapsulated Cells within the Brain
Microencapsulation of Cells in Thermoplastic Copolymer (Hydroxyethyl Methacrylate-Methyl Methacrylate)
Hydrogel Applications for Encapsulated Cellular Transplants
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Methods in Neurosciences Vol. 21 : Providing Pharmacological Access to the Brain, Alternate Approaches

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