Systems Biology and Synthetic Biology

The genomic revolution has opened up systematic investigations and engineering designs for various life forms. Systems biology and synthetic biology are emerging as two complementary approaches, which embody the breakthrough in biology and invite application of engineering principles. Systems Biology and Synthetic Biology emphasizes the similarity between biology and engineering at the system level, which is important for applying systems and engineering theories to biology problems. This book demonstrates to students, researchers, and industry that systems biology relies on synthetic biology technologies to study biological systems, while synthetic biology depends on knowledge obtained from systems biology approaches.

Pengcheng Fu, Phd, is a professor in the Faculty of Chemical Science and Engineering, China University of Petroleum, Beijing. His research interests include: biofuels and bioenergy, metabolic engineering, functional genomics, genome-scale modeling, bioprocess control, metabolomics/metabolite profiling, systems biology, and synthetic biology.

Dr. Sven Panke is an associate professor and leader of the Bioprocess Laboratory at the Department of Mechanical and Process Engineering of the ETH Zurich, Switzerland. His main interests are the design of novel biocatalysts for applications in chemistry and pharmacy by synthetic biology approaches.

Foreword	p. ix
Contributors	p. xi
Introduction	p. 1
Basics of Molecular Biology, Genetic Engineering, and Metabolic Engineering	p. 9
High-Throughput Technologies and Functional Genomics	p. 67
Genomic Signal Processing of DNA Microarray Data for the Enhanced Prediction of Axillary Lymph Node Status of Breast Cancer Tumors	p. 115
Recombinant Genomes: Novel Resources for Systems Biology and Synthetic Biology	p. 155
In silico Genome-Scale Metabolic Models: The Constraint-Based Approach and its Applications	p. 193
Mathematical Modeling of Genetic Regulatory Networks: Stress Responses in Escherichia coli	p. 235
Synthetic Life: Ethobricks for a New Biology	p. 273
Yeast as a Prototype for Systems Biology	p. 287
Construction and Applications of Genome-Scale in silico Metabolic Models for Strain Improvement	p. 355
Synthetic Biology: Putting Engineering into Bioengineering	p. 387
Rationales of Gene Design and de novo Gene Construction	p. 411
Self-Replication in Chemistry and Biology	p. 439
The Synthetic Approach for Regulatory and Metabolic Circuits	p. 467
Synthetic Gene Networks	p. 489
The Theory of Biological Robustness and its Implication to Cancer	p. 529
Nucleic Acid Engineering	p. 549
Potential Applications of Synthetic Biology in Marine Microbial Functional Ecology and Biotechnology	p. 577
On Fundamental Implications of Systems and Synthetic Biology	p. 593
Outstanding Issues in Systems and Synthetic Biology	p. 615
Index	p. 647
Table of Contents provided by Ingram. All Rights Reserved.

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Systems Biology and Synthetic Biology

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