Cancer Chemotherapy

, by Barton-Burke, Margaret; Wilkes, Gail M.; Ingwersen, Karen C.; Bean, Catherine K.; Berg, Deborah

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ISBN: 9780867207187 | 0867207183
Cover: Hardcover
Copyright: 4/1/1996

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Oncology Consulting Services, Boston, MA. Second edition of a clinical reference for practitioners. Previous edition 1991. Emphasizes the nursing process, including diagnosis and care plans. Concise format. Extensive use of charts. 13 U.S. contributors. DNLM: Neoplasms - nursing.

Preface to the Second Edition

Preface to the First Edition

xiii

Acknowledgments

Contributors

xvii

PART I From the Advent of Chemotherapy to Current Research: The Cancer Nurse's Role

Oncology Nursing Practice: The Role of the Nurse in Support of Progress in Cancer Treatment

(18)

Jean F. Jenkins

Evolution of Oncology Nursing

(1)

Unique Role of the Nurse in Cancer Chemotherapy

(3)

Unique Role of the Nurse in Cancer Research

(1)

The Development of the National Cancer Institute and Anticancer Drug Research

(1)

Clinical Trials

(1)

The Phases of Clinical Trials

(3)

Ethical Issues in Clinical Research

(2)

The Roles of Nurses in Clinical Oncology

(3)

Conclusion

(1)

Bibliography

(3)

Cell Cycle Kinetics and Antineoplastic Agents

(22)

Karen C. Ingwersen

History of Cancer Therapy

(2)

Advent of Cancer Chemotherapy

(2)

The Cell Cycle and Its Importance

(2)

Cell Cycle Phase-Specific Agents

(1)

Cell Cycle Phase-Nonspecific Agents

(1)

Chemotherapy and Cell Kinetics

(2)

Classification of Antineoplastic Agents

(5)

Rationale of Single-Agent Therapy versus Combination Therapy

(3)

Mechanisms of Drug Resistance

(1)

Conclusion

(2)

Bibliography

(2)

Biotherapy: The Fourth Modality

(32)

Paula Trahan Rieger

Historical Perspective

(4)

Definition of Terms

(1)

Classification

(1)

Agents

(10)

Combination Therapies

(2)

Nursing Implications

(2)

Conclusion

(6)

Bibliography

(6)

New Frontiers of Chemotherapy

(22)

Cynthia R. King

Introduction

(1)

Marrow/Stem Cell Transplantation

(10)

Colony-Stimulating Factors

(3)

Multidrug Resistance

(2)

Chemoprevention

(2)

Toxins

(1)

Conclusion

(1)

Bibliography

(5)

PART II Cancer Chemotherapy: Mechanisms and Nursing Care

Potential Toxicities and Nursing Management

(90)

Gail M. Wilkes

Introduction

(1)

Toxicity to Rapidly Proliferating Normal Cell Populations

(40)

Bone Marrow Depression (BMD)

(18)

Mucositis

116

(14)

Alopecia

130

(4)

Gonadal Dysfunction

134

(4)

Nausea and Vomiting

138

(15)

Antiemetic Treatment

144

(4)

Pharmacology of Antiemetics

148

(4)

Extrapyramidal Side Effects: Assessment and Intervention

152

(1)

Toxicity to Other Organ Systems

153

(34)

Introduction

153

(1)

Cardiotoxicity of Antineoplastic Drugs

153

(5)

Pulmonary Toxicity

158

(3)

Hepatotoxicity

161

(1)

Nephrotoxicity

161

(8)

Neurotoxicity

169

(11)

Bibliography

180

(7)

Chemotherapeutic Agents: Standardized Nursing Care Plans to Minimize Toxicity

187

(282)

Introduction

187

(1)

Acridinyl anisidide

188

(4)

Adrenocorticoids

192

(4)

Aminoglutethimide

196

(4)

Androgens

200

(3)

5-Azacytidine

203

(3)

Aziridinylbenzaquinone

206

(4)

Bleomycin sulfate

210

(6)

Busulfan

216

(2)

Camptothecin-11

218

(3)

Carboplatin

221

(4)

Carmustine

225

(4)

Chlorambucil

229

(4)

Cisplatin

233

(5)

Cladribine

238

(5)

Cyclophosphamide

243

(5)

Cytarabine, cytosine arabinoside

248

(4)

Dacarbazine

252

(6)

Dactinomycin

258

(5)

Daunorubicin hydrochloride

263

(5)

Dihydro-5-Azacytidine

268

(2)

Doxorubicin hydrochloride

270

(5)

Estramustine phosphate

275

(5)

Estrogens

280

(4)

Etoposide

284

(6)

Floxuridine

290

(5)

Fludarabine phosphate

295

(3)

5-Fluorouracil

298

(4)

Flutamide

302

(2)

Gallium nitrate

304

(2)

Gemcitabine

306

(3)

Hexamethylmelamine

309

(3)

Hydroxyurea

312

(4)

Idarubicin

316

(5)

Ifosfamide

321

(5)

L-asparaginase

326

(5)

Leucovorin calcium

331

(2)

Leuprolide acetate

333

(3)

Levamisole hydrochloride

336

(4)

Lomustine

340

(4)

Mechlorethamine hydrochloride

344

(7)

Melphalan

351

(5)

6-Mercaptopurine

356

(3)

Mesna

359

(2)

Methotrexate

361

(5)

Methyl-CCNU

366

(3)

Misonidazole

369

(2)

Mitoguazone dihydrochloride

371

(6)

Mitomycin

377

(5)

Mitotane

382

(3)

Mitoxantrone

385

(5)

Oxaliplatin

390

(3)

Paclitaxel

393

(6)

Pala

399

(3)

Pentostatin

402

(4)

Plicamycin

406

(4)

Procarbazine hydrochlorozide

410

(4)

Progestational agents

414

(2)

Streptozocin

416

(4)

Suramin sodium

420

(4)

Tamoxifen citrate

424

(3)

Taxotere

427

(4)

Teniposide

431

(5)

6-Thioguanine

436

(3)

Thiotepa

439

(3)

Trimetrexate

442

(3)

Vinblastine

445

(5)

Vincristine

450

(5)

Vindesine

455

(5)

Vinorelbine

460

(5)

Bibliography

465

(4)

Drug Interactions with Cancer Chemotherapy

469

(22)

Reginald S. King

Introduction

469

(1)

Pharmacokinetic Interactions

470

(5)

Pharmacodynamic Interactions

475

(3)

Miscellaneous

478

(1)

Conclusion

478

(9)

Bibliography

487

(4)

PART III Clinical Application

Care of the Pediatric Oncology Patient

491

(28)

Sue P. Heiney

Linda M. Wells

Introduction

491

(1)

History of Pediatric Oncology

491

(2)

Major Types of Childhood Cancers and Treatment

493

(2)

Care Plans

495

(22)

Bibliography

517

(2)

Chemotherapy in the Elderly: Considerations for Clinical Practice

519

(16)

Constance Engelking

Introduction

519

(1)

Barriers to Treatment

520

(9)

Age-Related Drug Toxicities

529

(2)

Nursing Considerations

531

(2)

Bibliography

533

(2)

Principles of Chemotherapy Administration

535

(26)

Deborah Berg

Introduction

535

(1)

Chemotherapy Checklist

536

(1)

Issues in Chemotherapy Administration in Ambulatory and Home Settings

537

(1)

Nursing Assessment: Prechemotherapy and Postchemotherapy

538

(1)

Reactions: Extravasation, Hypersensitivity, and Anaphylaxis

539

(19)

Bibliography

558

(3)

Drug Delivery Systems

561

(36)

Deborah Berg

Introduction

561

(1)

Routes of Administration

561

(6)

Intravenous Administration

567

(5)

Controversial Issues in Chemotherapy Administration

572

(1)

Dose Calculations and Modifications

572

(3)

Drug Interactions

575

(1)

Drug Delivery Systems

576

(16)

Conclusion

592

(2)

Bibliography

594

(3)

The Safe Handling of Cancer Chemotherapeutic Agents

597

(120)

Catherine K. Bean

Introduction

597

(1)

Historical Perspective of Cytotoxic Agents

598

(2)

Review of the Literature

600

(1)

Risk of Exposure

601

(1)

Recommended Guidelines for Safe Handling

601

(4)

Translating Guidelines into Practice

605

(1)

Safe Handling Practices in the Community

606

(5)

Conclusion

611

(1)

Bibliography

611

(5)

Appendices

Appendix 1: National Cancer Institute's Common Toxicity Criteria

616

(4)

Appendix 2: Chemotherapeutic Acronyms

620

(3)

Appendix 3: Controlling Occupational Exposure to Hazardous Drugs: OSHA Guidelines

623

(23)

Appendix 4: Cancer Chemotherapeutic Agents Compatibility Chart

646

(31)

Appendix 5: Nomograms for Determination of Body Surface Area from Height and Weight (Adults)

677

(1)

Appendix 6: Table of Standard Body Weights (Pounds--Kilograms)

678

(1)

Appendix 7: Nomograms for Determination of Body Surface Area from Height and Weight (Children)

679

(1)

Appendix 8: Examples of Pediatric Resources

680

(2)

Appendix 9: Yellow Pages for Cancer Chemotherapy

682

(35)

Index

717

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Cancer Chemotherapy

Summary

Table of Contents

Supplemental Materials