The Wiley-blackwell Handbook of Psychoneuroimmunology

• A much-needed reference including overviews of key advances in the field
• Discusses how psychoneuroimmunological research is conceived and executed
• Includes contributions from a wealth of experts in the field
• Forward by Robert Ader and Nicholas Cohen, founders of the discipline
• Authoritative and interdisciplinary in scope - integrating biological and behavioral science

Hymie Anisman is a full Professor in the department of Neuroscience, Carleton University, Canada. He holds the distinguished Canada Research Chair in Neuroscience. The principle theme of his research has been the influence of stressors on neurochemical, neuroendocrine and immune systems, and how these influence psychiatric disorders, including depression, anxiety and PTSD.

Preface ix
Alexander W. Kusnecov and Hymie Anisman

Foreword xiii
Robert Ader and Nicholas Cohen

List of Contributors xvii

1 Basic Principles in Immunology: Relevance for Studies in Psychoneuroimmunology 1
Sarah M. Clark, Kerry C. Michael, Achsah D. Keegan, and Leonardo H. Tonelli

2 Innervation of the Immune System 24
Denise L. Bellinger, Dwight M. Nance, and Dianne Lorton

3 In Vitro and In Vivo Assessment of Immune System Modulation of Brain Function and Neurochemistry 73
Michael O. Poulter and Zul Merali

4 Control and Contributions of the Blood–Brain Barriers to Cytokine Levels in the CNS 88
William A. Banks

5 The Immune–Neuroendocrine Network in Health and Disease 99
Adriana del Rey and Hugo O. Besedovsky

6 Neural Functions of Hematopoietic-derived Cells 120
Noel C. Derecki and Jonathan Kipnis

7 Immunoregulatory Neuropeptides 144
Doina Ganea and Mario Skarica

8 Regulation of Immune Cell Activity by Norepinephrine and β2-Adrenergic Receptor Engagement 161
Caroline J. Padro, Jaclyn W. McAlees, and Virginia M. Sanders

9 Immune-to-Brain Communication in Pain: Historical Perspectives, New Directions 176
Peter M. Grace, Linda R. Watkins, and Mark R. Hutchinson

10 Stress and Neuroendocrine–Immune Interaction: A Therapeutic Role for β-endorphin 198
Olivia Wynne and Dipak K. Sarkar

11 Assessing Neuroendocrine-Mediated Modulation of Immunity to Infection in Animals: Caveats and Methodological Issues 212
Jodi L. Yorty and Robert H. Bonneau

12 Approaches to Assessing Stressor-Induced Cytokine and Endocrine Changes in Humans 234
Kim Matheson and Hymie Anisman

13 Stress and Immune Function in Humans: A Life-Course Perspective 251
Jan A. Moynihan, Kathi L. Heffner, Mary T. Caserta, and Thomas G. O’Connor

14 Predicting Health: The Role of the Early-Life Environment 266
Luba Sominsky, Adam K. Walker, and Deborah M. Hodgson

15 Microglia and Neurodevelopment: Programming of Cognition throughout the Lifespan 296
Jaclyn M. Schwarz and Staci D. Bilbo

16 Aging and the Immune System 313
Ashley M. Fenn, Angela W. Corona, and Jonathan P. Godbout

17 Peripheral Pro-inflammatory Cytokines and Cognitive Aging: The Role of Metabolic Risk 330
Alvin Lim and Anna Marsland

18 Immune Stimulation and Cognitive Function: Defining the Deficits and Avoiding the Pitfalls 347
Colm Cunningham

19 The Role of NF-κB in Behavioral and Neural Plasticity 365
Elyse M. Mallimo and Alexander W. Kusnecov

20 Inflammatory Roads to Neurodegeneration: A Focus on Parkinson’s and Alzheimer’s Disease 393
Shawn Hayley and Darcy Litteljohn

21 The Psychotic Face of the Immune System: Inflammation and Schizophrenia 411
Urs Meyer

22 Neuroimmune Mechanisms in Autism 425
Veronica M. Miller, Rachael Racine, and Steven S. Zalcman

23 Depression, Inflammation and Tryptophan Metabolism 448
Robert H. McCusker, Annemieke Kavelaars, Cobi J. Heijnen, Robert Dantzer, and Keith W. Kelley

24 An Inflammatory Perspective of Stress and Human Depressive Disorder 469
M.-C. Audet, S. Jacobson-Pick, R. McQuaid, and Hymie Anisman

25 Interaction Between Immune and Energy-Balance Signals in the Regulation of Feeding and Metabolism 488
Alfonso Abizaid, Giamal Luheshi, and Barbara C. Woodside

26 Psychoneuroimmunological Processes in Coronary Artery Disease and Heart Failure 504
Willem J. Kop and Paula M.C. Mommersteeg

Index 525

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