The GABA Receptors

"The Gaba Receptors, Third Edition", presents a critical appraisal of our current understanding of the molecular, behavioral, biochemical, clinical, and pharmacological properties of GABA receptors. Emphasis is placed on exploring cutting-edge findings on the structural properties of receptor sites, mechanisms of receptor expression, chemical agents that differentiate receptor subtypes, and phenotypes displayed by GABA receptor null mice. Chapters in this updated and expanded edition examine such topics as GABA receptor subtypes, trafficking postsynaptic GABA receptors, GABA receptor mutations associated with idiopathic generalized epilepsies and febrile seizures, and GABA receptors as a potential therapeutic target.

Preface	p. v
Contributors	p. ix
The GABA Receptors	p. 1
Functional Relevance of GABA[subscript A]-Receptor Subtypes	p. 23
Trafficking of Postsynaptic GABA[subscript A] Receptors by Receptor-Associated Proteins	p. 41
Subunit Composition and Structure of GABA[subscript A]-Receptor Subtypes	p. 69
Differential Activation of GABA[subscript A]-Receptor Subtypes	p. 87
GABA[subscript A]-Receptor Mutations Associated With Idiopathic Generalized Epilepsies and Febrile Seizures	p. 111
Abuse and Dependence Liability of GABA[subscript A]-Receptor Modulators: Antecedents and Pharmacology	p. 143
Mechanisms of GABA[subscript A] and GABA[subscript B] Receptor Gene Regulation and Cell Surface Expression	p. 239
Chemistry of GABA[subscript B] Modulators	p. 239
The Unusual Functioning of the GABA[subscript B]-Receptor Heterodimer: An Old Receptor Teaching New Functional Tricks?	p. 253
Characteristics of GABA[subscript B] Receptor Mutant Mice	p. 273
GABA[subscript B] Receptor as a Potential Therapeutic Target	p. 289
Index	p. 313
Table of Contents provided by Ingram. All Rights Reserved.

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