Prostate Cancer

, by Pestell, Richard G.; Nevalainen, Marja T., M.D., Ph.D.; Milken, Michael

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ISBN: 9781588297419 | 1588297411
Cover: Hardcover
Copyright: 3/30/2008

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Award winning authors present a comprehensive review of new perspectives in prostate cancer research and open up new directions in the clinical management of prostate cancer. The authors focus on the biology, genetics, molecular signaling networks in the disease process, and recent advances in the treatment of prostate cancer. This state-of-the-art title provides key insights into cutting edge advances in prostate cancer and into future, novel treatment strategies.

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Histopathology and Molecular Biology of Prostate Atrophy: A Lesion Associated with Inflammation, Prostate Intraepithelial Neoplasia, and Prostate Cancer	p. 1
Epigenetic Gene Silencing in Prostate Cancer	p. 17
Inherited Genetic Changes in Prostate Cancer	p. 53
Prostate Molecular Oncogenesis: Gene Deletions and Somatic Mutations	p. 71
Somatic Genetic Changes in Prostate Cancer: Androgen Receptor Alterations	p. 99
Androgen Receptor in Prostate Cancer Progression	p. 129
Epigenetic Modification and Acetylation of Androgen Receptor Regulate Prostate Cellular Growth	p. 147
Estrogen Receptor [alpha] and [beta] in the Regulation of Normal and Malignant Prostate Epithelium	p. 163
Estrogen Action in Normal Prostate Epithelium and in Prostate Cancer	p. 181
Hypoxia-Inducible Factor 1 in the Angiogenesis of Prostate Cancer	p. 209
Signal Transduction by the Ras-MAP Kinase Pathway in Prostate Cancer Progression	p. 223
Transcription Factors STAT5 and STAT3: Survival Factors for Prostate Cancer Cells	p. 257
Role of PI3K-Akt and PTEN in the Growth and Progression of Prostate Cancer	p. 291
New Perspectives in Prediction of Clinical Outcome of Prostate Cancer: TMPRSS2-ETS Gene Fusion in Prostate Cancer	p. 309
New Directions in Radiation Therapy of Prostate Cancer: Brachytherapy and Intensity-Modulated Radiation Therapy	p. 323
The Current Knowledge of Hormonal Therapy in the Treatment of Prostate Cancer	p. 339
Advances in Surgical Intervention of Prostate Cancer: Comparison of the Benefits and Pitfalls of Retropubic, Perineal, and Laparoscopic Radical Prostatectomy	p. 355
Targeted Therapy Trials for Prostate Cancer	p. 383
New Perspectives on Chemotherapy in Prostate Cancer	p. 401
Concluding Remarks: The Future of Prostate Cancer	p. 427
Index	p. 439
Table of Contents provided by Blackwell. All Rights Reserved.

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Prostate Cancer

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