Coumarins Biology, Applications and Mode of

Coumarins: Biology, Applications and Mode of Action predominantly focuses on the parent compound, coumarin, and its main metabolite in humans, 7-hydroxycoumarin. It describes in detail every facet of these compounds including history, toxicology, chemistry, metabolism, analysis, clinical, veterinary and other applications, their roles as immunomodulatory agents and speculates on their mode of action.

Richard O'Kennedy is the editor of Coumarins: Biology, Applications and Mode of Action, published by Wiley.

R. Douglas Thornes is the editor of Coumarins: Biology, Applications and Mode of Action, published by Wiley.

List of Contributors

vii

(2)

Preface

ix

1. History of the Development and Applications of Coumarin and Coumarin-related Compounds

22

(1)

Inge Weinmann

2. The Chemistry and Occurrence of Coumarins

23

(44)

Gary J. Keating

Richard O'Kennedy

3. The Metabolism of Coumarin

67

(26)

Olavi Pelkonen

Hannu Raunio

Arja Rautio

Markku Pasanen

Matti A. Lang

4. The Effects of Coumarin and its Metabolites on Cell Growth and Development

93

(10)

Barbara Seliger

5. Coumarin as an Immunomodulator

103

(22)

Gerhard J. Zlabinger

6. The Mode of Entry of Coumarin into Cells and its Effects on Cell-Cell Communication and Migration

125

(18)

Kurt S. Zanker

7. Coumarin in the Treatment of Lymphoedema and Other High-Protein Oedemas

143

(42)

John R. Casley-Smith

Judith R. Casley-Smith

8. Mode of Action of Coumarin in the Treatment of Thermal Injuries

185

(24)

Neil B. Piller

9. Renal Cell Carcinoma: The Background, Rationale and Current Development of Coumarin (1,2-benzopyrone) as a Potential Therapeutic Agent

209

(32)

Scot W. Ebbinghaus

James L. Mohler

M. Ernest Marshall

10. The Potential Role of Coumarins in the Therapy of Prostate Cancer

241

(14)

James L. Mohler

Bernadette T. Williams

John A. Freeman

M. Ernest Marshall

11. Clinical and Biological Observations Associated with Coumarins

255

(12)

R.D. Thornes

12. Analysis of Coumarins

267

(36)

Declan P. Bogan

Gary J. Keating

Heiko Reinartz

Ciaran F. Duffy

Malcolm R. Smyth

Richard Kennedy

13. Coumarins--Multifaceted Molecules with Many Analytical and Other Applications

303

(30)

Deirdre Cooke

Brian Fitzpatrick

Richard O'Kennedy

Teresa McCormack

Denise Egan

14. Suggested Modes of Action of Coumarins and Some Comments on their Significance

333

(4)

Richard O'Kennedy

R.D. Thornes

Index

337

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Coumarins Biology, Applications and Mode of Action

Summary

Author Biography

Table of Contents

Supplemental Materials