Uncommon Gynecologic Cancers

Rare gynecological cancers kill all too commonly

Gynecological cancer is a frightening prospect for women. It is terrifying also for physicians who need, but often can’t find, guidance on how to investigate and appropriately treat the tumors. Rare cancers provide greater challenges as information can be harder to find and more difficult to verify.

Rare Gynecologic Cancers: Diagnosis and Management brings together all you need to know on these life-threatening diseases. Straightforward summaries of pathophysiologic processes lead to the investigations that will improve your diagnostic accuracy. This provides the basis for you to identify effective treatment strategies for your patients. Written by a world-leading team of Editors and Authors and covering cancers of the

•             Ovaries

•             Uterus

•             Vulva

•             Vagina

•             Cervix

Rare Gynecologic Cancers: Diagnosis and Management will guide you to the best life-saving treatment for your patients.

John O. Schorge, MD, Associate Professor of Obstetrics and Gynecology, Harvard Medical School, Boston and Chief, Gynecologic Oncology, OB/GYN, Massachusetts General Hospital.

Robert H Young, MD, Robert E. Scully Professor of Pathology, Harvard Medical School, Boston.

Michael J Birrer, MD, PhD, Professor, Department of Medicine, Harvard Medical School.

Marcela del Carmen, MD, Associate Professor, Department of Obstetrics, Gynecology and Reproductive Biology, Harvard Medical School and Associate Professor, Gynecologic Oncology, Massachusetts General Hospital.

List of Contributors, vi

Preface, viii

Part 1 General Principles, 1

1 Molecular Targets in Gynecologic Cancers, 3
Whitfield Growdon, Rosemary Foster, and Bo Rueda

2 Imaging of Rare Gynecologic Tumors, 18
Hima B. Prabhakar and Dinushi S. Perera

3 Pathology Overview of Rare Gynecologic Tumors, 35
Robert H. Young

Part 2 Rare Ovarian Cancers, 51

4 Ovarian Clear Cell Carcinoma, 53
Rachel M. Clark and John O. Schorge

5 Mucinous Epithelial Ovarian Cancer, 64
Marcela G. del Carmen

6 Pseudomyxoma Peritonei, 70
Leslie S. Bradford and Annekathryn Goodman

7 Squamous Cell Carcinoma of the Ovary, 81
Ryan J. Spencer and Laurel W. Rice

8 Endometriosis-Associated Ovarian Cancer, 94
Leslie A. Garrett and Marcela G. del Carmen

9 Carcinosarcoma of the Ovary, 109
J. Alejandro Rauh-Hain and Marcela G. del Carmen

10 Malignant Germ Cell Tumors of the Ovary, 120
Marcela G. del Carmen

11 Malignant Sex Cord-Stromal Tumors of the Ovary, 132
Marcela G. del Carmen and Richard T. Penson

12 Small Cell and Neuroendocrine Cancers of the Ovary, 139
Ariel A. Kaphan and Cesar M. Castro

13 Carcinoid Tumors of the Ovary, 148
Michael J. Worley, Jr. and Michael G. Muto

Part 3 Rare Uterine Cancers, 157

14 Uterine Carcinosarcoma, 159
Premal H. Thaker and Don S. Dizon

15 Uterine Leiomyosarcoma, 167
Marcela G. del Carmen

16 Mucinous Tumors of the Uterine Corpus, 178
Rachel M. Clark and Marcela G. del Carmen

17 Uterine Clear Cell Carcinoma, 186
J. Alejandro Rauh-Hain, Alexander B. Olawaiye, and David M. Boruta

18 Updates on the Management of Uterine Serous Carcinoma, 195
Amanda Ramos and Amanda Nickles Fader

19 Endometrial Stromal Sarcomas, 205
Kathleen M. Schmeler, J. Alejandro Rauh-Hain, and Marcela G. del Carmen

Part 4 Rare Cancers of the Cervix, Vulva and Vagina, 217

20 Small Cell Neuroendocrine Carcinoma of the Cervix, 219
Olivia W. Foley, Leslie S. Bradford, and Marcela G. del Carmen

21 Primary Malignant Melanoma of the Vagina and Vulva, 228
Alexander B. Olawaiye

22 Sarcomas of the Vulva and Vagina, 236
Rachel M. Clark, J. Alejandro Rauh-Hain, and Marcela G. del Carmen

23 Gestational Trophoblastic Disease, 245
Whitfield Growdon

Index, 260

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