Advances in Genetics

Advances in Genetics increases its focus on modern human genetics and its relation to medicine with the merger of this long-standing serial with Molecular Genetic Medicine. This merger affirm our commitment to publish important reviews of the broadest interest to geneticists and their colleagues in affiliated disciplines. This volume of Advances in Genetics contains articles on: Rapidly Evolving Rab GTPase Paralogs and Reproductive Isolation in Drosophila, The Neurospora crassa Circadian Clock, Involvement of Homologous Recombination in Carcinogenesis, Mutational Analysis of the Ribosome, Application of Genomics to Molecular Breeding of Wheat and Barley. Book jacket.

Contributors	p. vii
Rapidly Evolving Rab GTPase Paralogs and Reproductive Isolation in Drosophila	p. 1
Introduction	p. 2
Experimental Approaches	p. 5
Influences of Rab9D on Viability of Hybrids Between D. melanogaster and Its Sibling Species	p. 5
Predictions of Functions for 6paRAB9 Proteins	p. 14
General Considerations	p. 16
References	p. 20
The Neurospora crassa Circadian Clock	p. 25
Introduction	p. 26
Neurospora as a Circadian Model System	p. 27
The Molecular Machinery of the Neurospora Circadian Oscillator	p. 28
Temporal Input from the Environment	p. 42
Temporal Output from the Oscillator	p. 54
FRQ-Less Oscillators	p. 56
Conclusions	p. 58
References	p. 59
Involvement of Homologous Recombination in Carcinogenesis	p. 67
Introduction	p. 68
HR Involvement in DNA Repair	p. 69
HR and Carcinogenesis	p. 71
Other Diseases Attributable to HR	p. 75
Carcinogen-Induced HR in Experimental Systems	p. 76
Summary	p. 79
References	p. 80
Mutational Analysis of the Ribosome	p. 89
Introduction	p. 90
Mutational Analysis of 16S rRNA Structure and Function	p. 91
Mutational Analysis of 23S rRNA Structure and Function	p. 97
Mutational Analysis of Ribosomal Protein Structure and Function	p. 103
Mutational Analysis of Ribosomal Factor Structure and Function	p. 106
Concluding Remarks	p. 108
References	p. 109
Application of Genomics to Molecular Breeding of Wheat and Barley	p. 121
Introduction	p. 122
Molecular Markers and Marker-Assisted Breeding	p. 123
Genomic Resources and Approaches	p. 131
Comparative Genomics	p. 137
Exploitation of Natural Variation and Allelic Diversity	p. 138
Concluding Remarks	p. 143
References	p. 144
Index	p. 157
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