Advances in Genetics

Advances in Genetics increases its focus on modern human genetics and its relation to medicine with the merger of this long-standing serial with Molecular Genetic Medicine. This merger affirms theAcademic Press commitment to publish important reviews of the broadest interest to geneticists and their colleagues in affiliated disciplines.

Contributors

vii

The Peripheral Neuropathies and Their Molecular Genetics

1

(44)

C. Bell

N. Haites

Historical Introduction

2

(1)

Clinical Classification of CMT

2

(2)

Genetic Classification

4

(4)

Molecular Mechanisms in CMT1A

8

(11)

Molecular Mechanisms of CMT1B, DSD, and CMTX1

19

(2)

Myelin Proteins and Their Functional Significance

21

(13)

Molecular Diagnostic Testing for CMT and HNPP

34

(11)

References

36

(9)

Tumor Suppressor Genes and Human Cancer

45

(92)

Melissa A. Brown

Introduction

46

(7)

Tumor Suppressor Genes and Their Products

53

(41)

The Role of Tumor Suppressor Genes in Human Cancer

94

(11)

Conclusions

105

(32)

References

107

(30)

Genetic Redundancy

137

(20)

John F. Y. Brookfield

Introduction: The Evolutionary Background of Adaptation and Pleiotropy

138

(1)

Evidence for redundancy

139

(4)

Apparent and True Redundancy

143

(7)

The Organism and the Cell

150

(1)

Redundancy as a Fail-Safe System

151

(1)

Functional Redundancy

152

(1)

Conclusions

153

(4)

References

153

(4)

Genetics of Hybrid Inviability in Drosophila

157

(30)

Pierre Hutter

Introduction

157

(2)

Genetic Studies on Hybrid Inviability

159

(9)

Chromosomes and genes Influencing Hybrid Viability

168

(7)

Genetic Models for the Basis of Hybrid Inviability

175

(4)

Conclusions

179

(8)

References

181

(6)

Regulation of Bacterial Gene Expression by Metals

187

(52)

David J. Westenberg

Mary Lou Guerinot

Introduction

187

(3)

Essential Metals

190

(15)

Toxic Metals

205

(21)

Concluding Remarks

226

(13)

References

227

(12)

Chromosome Rearrangements in Neurospora and Other Filamentous Fungi

239

(160)

David D. Perkins

Introduction

241

(4)

General Information Regarding Neurospora Rearrangements

245

(11)

New Findings

256

(21)

Rearrangements in Other Fungi

277

(8)

Individual Chromosome Rearrangements of Neurospora crassa

285

(97)

Summary

382

(17)

References

383

(16)

Index

399

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Summary

Table of Contents

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