Advances in Optical Imaging for Clinical

This book provides students, teachers, researchers and clinicians with a strong and established source of information on advanced optical technologies that show real promise of being translated to clinical use.

Nicusor Iftimia is leader of the Advanced Microscopy and Image Guided Interventions Group at Physical Sciences, Inc. in Andover, Massachusetts. He has been awarded several NIH and DoD grants to conduct cutting edge research in biomedical optics imaging for cancer diagnosis and therapy guidance. He has published over forty peer-reviewed journal papers, is the author of several book chapters, and a co-inventor of more than ten patents. William R. Brugge is Director of the Gastrointestinal Endoscopy Unit at the Massachusetts General Hospital and Professor of Medicine at Harvard Medical School. Dr. Brugge pioneered the use of endoscopic ultrasound imaging in the diagnosis and staging of gastrointestinal malignancies, particularly early malignancies of the pancreas. Daniel X. Hammer is leader of the Biomedical Imaging Group at Physical Sciences, Inc. in Andover, Massachusetts. He specializes in the development of innovative biomedical optical instruments, conducting international award-winning research in the area of ophthalmology and adaptive optics. He has published more than forty peer-reviewed journal papers and is a co-inventor of more than ten patents.

Introduction
Traditional Imaging Modalities in Clinical Medicine
Introduction
Diagnostic imaging technologies
Imaging for radiation therapy planning
Image-guided radiation therapy
Conclusions
Current imaging approaches and further imaging needs in clinical medicine: A clinician perspective
Ophthalmic Imaging
Imaging of the Gastrointestinal Mucosa
Cardioimaging
Neuroimaging: current technologies and further needs
Advances in Retinal Imaging
Introduction
Prevalent Retinal Diseases
Traditional Imaging Technologies
Advanced Imaging Technologies
Imaging Beyond Disease Detection
Conclusion
Confocal Microscopy of Skin Cancer
Introduction
Imaging of Normal Skin In Vivo
Imaging of Cutaneous Neoplasms In Vivo - correlation with dermoscopy and histopathology
Mosaicing of Excised Skin Ex Vivo
Intra-operative Mapping of Surgical Margin
Challenging Cases
Future perspectives
Acknowledgements
High-resolution optical coherence tomography imaging in gastroenterology
Introduction
Optical Coherence Tomography
Clinical Gastrointestinal Imaging
Future Directions
Conclusions
High-resolution confocal endomicroscopy for gastrointestinal cancer detection
Introduction and motivation
Conventional confocal endomicroscopy
Dual-axis confocal endomicroscopy
Toward larger fields of view?mosaicing
Summary and future directions
High-resolution Optical Imaging in Interventional Cardiology
Introduction
Current Invasive Imaging Modalities In interventional Cardiology
High-resolution optical coherence tomography imaging in
Current Limitations of OCT
Future developments
Conclusion
Fluorescence Lifetime Spectroscopy in Cardio and Neuroimaging
Introduction
Fluorescence lifetime spectroscopy in tissue characterization
Time-Resolved Fluorescence Spectroscopy - Instrumentation
Time-Resolved Fluorescence Spectroscopy - Data Analysis Methods
Atherosclerotic plaque
Primary brain tumors
Concluding remarks
Acknowledgments
References
Advanced Optical Methods for Functional Brain Imaging
Introduction
Optical technologies for noninvasive neural activity mapping
Optical imaging of the depth-resolved functional activity in cortex
Novel approaches
Conclusions
Advances in Optical Mammography
Introduction
Structure and Physiology of human female breast: an optical perspective
Optical Imaging breast technology
In-vivo optical properties of healthy breast
Optical imaging in breast oncology
Multimodality Approaches
Summary
Photoacoustic Tomography
Introduction
Photoacoustic Theory
PAT Imaging Methods
Photoacoustic Wave Equations
Finite Element and Model-Based PAT Reconstruction Methods
Quantitative PAT
PAT Imaging Instrumentation
In vivo Applications
References
Optical Imaging and Measurement of Angiogenesis
Introduction
Angiogenesis ? A brief overview
Potential clinical applications
Optical techniques to image angiogenesis
Other modalities
Conclusions
High-resolution Phase Contrast Optical Coherence Tomography for Functional Biomedical Imaging
Introduction
Time Domain Phase Sensitive Interferometry
Spectral Domain Phase Sensitive Interferometry
Applications of differential phase contrast imaging
Comparison of time domain and spectral domain phase-sensitive systems
Conclusion
Polarization imaging
Introduction
Polarization analysis
Polarization microscopy
Biomedical applications
Other polarization imaging applications
Conclusions
Nanotechnology Approaches for Contrast Enhancement in Optical Imaging and Disease Targeted Therapy
Introduction
Nanotechnology-based contrast agents for optical imaging and targeted therapy
Enhanced contrast optical imaging using functionalized nonoprobes
Nanotechnology-based drug delivery systems for disease-targeted therapy and tissue
Conclusions
Molecular probes for optical contrast enhancement of gastrointestinal cancers
Introduction
DNA Microarrays for Target Identification
Phage Display
Potential Targets and Possible Pitfalls
Probe Design
Conclusion
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Advances in Optical Imaging for Clinical Medicine

Summary

Author Biography

Table of Contents

Supplemental Materials