Advances in Physical Organic Chemistry

The objective of the serial is to present considered reviews on the quantitative study of organic compounds and their behavior--physical organic chemistry in its broadest sense--in a manner accessible to a general readership.

Preface

vii

Contributors to Volume 31

ix

Electrochemical Recognition of Charged and Neutral Guest Species by Redox-active Receptor Molecules

1

(90)

Paul D. Beer

Philip A. Gale

Zheng Chen

Introduction

1

(5)

Electrochemical recognition of cationic guest species by redox-active receptor molecules

6

(44)

Electrochemical recognition of anionic guest species by redox-active receptor molecules

50

(21)

Towards electrochemical recognition of neutral guest species by redox-active receptor molecules

71

(5)

Conclusions

76

(1)

Acknowledgements

77

(3)

References

80

(11)

Appendix: Understanding cyclic voltammetry and square-wave voltammetry

84

(7)

Spin Trapping and Electron Transfer

91

(52)

Lennart Eberson

Introduction

91

(2)

Redox mechanisms of spin trapping

93

(3)

Electron transfer theory

96

(5)

Spin trapping and electron transfer

101

(4)

Evidence for the ST.+-nucleophile mechanism under thermal conditions

105

(9)

Properties of the PBN and DMPO radical cations

114

(2)

Anodic spin trapping experiments

116

(2)

Photochemical spin trapping experiments

118

(3)

Example of problems in photo-initiated spin trapping

121

(5)

Ionizing radiation and spin trapping

126

(1)

Spin trapping of radicals generated by ultrasound (sonolysis)

126

(1)

Spin trapping in biochemical/biological systems

127

(2)

Conclusions on the radical cation mechanism

129

(1)

Spin adduct formation via radical anions

129

(1)

The nucleophilic addition--oxidation mechanism

130

(6)

Bona fide spin trappings: a recipe

136

(7)

References

137

(6)

Secondary Deuterium Kinetic Isotope Effects and Transition State

143

(106)

Olle Matsson

Kenneth C. Westaway

Introduction

144

(2)

Secondary α-deuterium KIEs in SN reactions

146

(51)

Secondary β-deuterium KIEs

197

(14)

Secondary deuterium KIEs and tunnelling

211

(20)

Remote secondary deuterium KIEs

231

(3)

New methods for the accurate determination of secondary deuterium KIEs

234

(8)

Conclusion

242

(7)

Acknowledgements

242

(1)

References

243

(6)

Catalytic Antibodies

249

(144)

G. Michael Blackburn

Anita Datta

Hazel Denham

Paul Wentworth Jr

Glossary

250

(3)

Introduction

253

(8)

Approaches to hapten design

261

(15)

Spontaneous features of antibody catalysis

276

(2)

Performance analysis of catalytic antibodies

278

(3)

A case study: NPN43C9--an antibody anilidase

281

(4)

Rescheduling the regio- and stereo-chemistry of chemical reactions

285

(7)

Difficult processes

292

(9)

Reactive immunization

301

(3)

Medical potential of abzymes

304

(5)

Industrial potential of abzymes

309

(2)

Conclusions

311

(82)

Appendix: Catalogue of antibody-catalysed processes

313

(72)

References

385

(8)

Author Index

393

(14)

Cumulative Index of Authors

407

(2)

Cumulative Index of Titles

409

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Advances in Physical Organic Chemistry

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