ADVANCES IN PROTEIN CHEMISTRY VOL 10

This volume in the Advances in Protein Chemistry series features cutting-edge articles on topics in protein chemistry. This volume includes chapters on the structural basis of effector regulation and signal termination in heterotrimeric G??????n??nproteins; How do receptors activate G proteins; Some mechanistic insights into GPCR activation from detergent solubilized ternary complexes on beads; Activation of G protein coupled receptors; Kinetic analysis of g-protein-coupled receptor signaling using fluorescence resonance energy transfer in living cells; Regulation of Rho Guanine Nucleotide Exchange Factors (RhoGEFs) by G proteins.

Preface	p. vii
Structural Basis of Effector Regulation and Signal Termination in Heterotrimeric G[alpha] Proteins
Introduction and Scope	p. 3
A Selective Survey of G[alpha]Protein Structurc and Function	p. 5
Mechanisms of Effector Recognition and Regulation by G[alpha]GTP	p. 9
Signal Termination: The Mechanism of GTP Hydrolysis and Conformational Deactivation	p. 23
Signal Termination Through GAPs and Effector GAP Domains	p. 38
Conclusions	p. 51
References	p. 52
Receptors Activate G Proteins?
Introduction	p. 67
Toward a Model of the Receptor-G Protein Complex	p. 72
Molecular Basis for G Protein Activation	p. 80
Summary and Conclusions	p. 84
References	p. 86
Some Mechanistic Insights into GPCR Activation from Detergent-Solubilized Ternary Complexes on Beads
Perspectives	p. 96
Survey of Experimental Approaches and Representative Data	p. 99
Analysis of Soluble Receptor Ternary Complex Assemblies	p. 104
Guanine Nucleotide Activation of Ternary Complex: Some Dynamic Aspects of Structure and Reactivity	p. 117
References	p. 128
Activation of G Protein-Coupled Receptors
Introduction	p. 138
Structural and Mechanistic Homology Among GPCRs	p. 140
Conformational States	p. 143
Activation by Agonists	p. 148
Concluding Remarks	p. 159
References	p. 159
Kinetic Analysis of G Protein-Coupled Receptor Signaling Using Fluorescence Resonance Energy Transfer in Living Cells
Introduction	p. 167
Assays and Methods	p. 170
Results and Discussion	p. 179
Conclusions	p. 184
References	p. 185
Regulation of Rho Guanine Nucleotide Exchange Factors by G Proteins
Introduction	p. 190
RGS-RhoGEFs	p. 193
Mechanisms of Regulation	p. 201
Physiological Function of the RGS-RhoGEFs	p. 213
References	p. 221
Author Index	p. 229
Subject Index	p. 247
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