Advances in Veterinary Dermatology, Volume 7 Proceedings of the Seventh World Congress of Veterinary Dermatology, Vancouver, Canada, July 24 - 28, 2012

Representing the state of the art of veterinary dermatology around the globe, Advances in Veterinary Dermatology, Volume 7, presents selected scientific papers from the Seventh World Congress of Veterinary Dermatology.  The Congress, held in Vancouver, Canada in July 2012, was organized with the support of the World Association for Veterinary Dermatology (WAVD) and its affiliated societies.   A record number of delegates attended from over 50 countries to take advantage of the exceptional scientific program.  Cutting edge information was presented as review papers and original studies in the areas of:

• Allergy
• Immunology   
• Skin Biology   
• Therapy
• Infectious Diseases
• Oncology

These peer-reviewed and edited papers were published in the journal Veterinary Dermatology in volume 24, issue 1, and are included in this hardbound book volume of the conference proceedings.  Also included are 13 Workshop Reports which summarise sessions where experts presented topics in various areas providing a wonderful opportunity for colleagues to ask questions and exchange ideas in an informal atmosphere.

A vital resource for all practising veterinarians and researchers interested in the field of veterinary dermatology.

EDITOR:

Sheila M. F. Torres DVM, MS, PhD, Diplomate of the American College of Veterinary Dermatology. Professor in Dermatology at the University of Minnesota, College of Veterinary Medicine, USA.

CO-EDITORS:

Linda A. Frank DVM, MS, Diplomate of the American College of Veterinary Dermatology. Professor in Dermatology at the University of Tennessee, College of Veterinary Medicine, USA.

Ann M. Hargis DVM, MS, Diplomate of the American College of Veterinary Pathologists. Owner of DermatoDiagnostics, affiliate faculty at the Department of Comparative Medicine, University of Washington, Seattle, USA. Member of the American Academy of Veterinary Dermatology and the International Society of Veterinary Dermatopathology.

Sponsors

Officers and Organizing Committees

Members of the Administrative Committee of the WAVD

Preface

PART 1 ALLERGY

1.1 Epidemiology of human atopic dermatitis – seven areas of notable progress and seven areas of notable ignorance 3

Hywel C. Williams

1.2 The genomics revolution: will canine atopic dermatitis be predictable and preventable?

Tim Nuttall

1.3 Serum anti-Staphylococcus pseudintermedius IgE and IgG antibodies in dogs with atopic dermatitis and nonatopic dogs

Jennifer Bexley, Timothy J. Nuttall, Bruce Hammerberg, J. Ross Fitzgerald and Richard E. Halliwell

1.4 Characterization of canine filaggrin: gene structure and protein expression in dog skin

Satoko Kanda, Takashi Sasaki, Aiko Shiohama, Koji Nishifuji, Masayuki Amagai, Toshiroh Iwasaki and Jun Kudoh

PART 2 IMMUNOLOGY

2.1 Innate immune defense system of the skin

Maryam Afshar and Richard L. Gallo

2.2 Evaluation of canine antimicrobial peptides in infected and noninfected chronic atopic skin

Domenico Santoro, David Bunick, Thomas K. Graves and Mariangela Segre

2.3 Interleukin-31: its role in canine pruritus and naturally occurring canine atopic dermatitis

Andrea J. Gonzales, William R. Humphrey, James E. Messamore, Timothy J. Fleck, Gregory J. Fici, John A. Shelly, Janet F. Teel, Gary F. Bammert, Steven A. Dunham, Troy E. Fuller and Robert B. McCall

2.4 Expression of thymic stromal lymphopoietin in canine atopic dermatitis

Jolanta Klukowska-Roetzler, Ludovic Chervet, Eliane J. Mueller, Petra Roosje, Eliane Marti and Jozef Janda

PART 3 SKIN BIOLOGY

3.1 The stratum corneum: the rampart of the mammalian body

Koji Nishifuji and Ji Seon Yoon

3.2 Fixing the skin barrier: past, present and future – man and dog compared

Rosanna Marsella

3.3 Autosomal recessive ichthyosis in golden retriever dogs: distribution and frequency of the PNPLA1 mutant allele in different populations*

Eric Guaguere, Anne Thomas, Anais Grall, Emmanuelle Bourrat, Laetitia Lagoutte, Frederique Degorce-Rubiales, Christophe Hitte, Emmanuel Bensignor, Jacques Fontaine, Didier Pin, Guillaume Queney and Catherine Andre

3.4 Epidermal structure created by canine hair follicle keratinocytes enriched with bulge cells in a three-dimensional skin equivalent model in vitro: implications for regenerative therapy of canine epidermis

Tetsuro Kobayashi, Kaoru Enomoto, Yu Hsuan Wang, Ji Seon Yoon, Ryoko Okamura, Kaori Ide, Manabu Ohyama, Toshio Nishiyama, Toshiroh Iwasaki and Koji Nishifuji

3.5 Skin lipid profiling in normal and seborrhoeic shih tzu dogs

Ji-Seon Yoon, Koji Nishifuji, Sinpei Ishioroshi, Kaori Ide and Toshiroh Iwasaki

*This study was not published in the special issue of the Veterinary Dermatology journal (VDE 2013; 24:1).

PART 4 THERAPY

4.1 Stem cell therapy in veterinary dermatology

Robert J. Harman

4.2 A systematic review of randomized controlled trials for prevention or treatment of atopic dermatitis in dogs: 2008–2011 update

Thierry Olivry and Petra Bizikova

4.3 The effect of ketoconazole on whole blood and skin ciclosporin concentrations in dogs

Laura L. Gray, Andrew Hillier, Lynette K. Cole and Paeivi J. Rajala-Schultz

4.4 In vitro antiseptic susceptibilities for Staphylococcus pseudintermedius isolated from canine superficial pyoderma in Japan

Nobuo Murayama, Masahiko Nagata, Yuri Terada, Mio Okuaki, Noriyuki Takemura, Hidemasa Nakaminami and Norihisa Noguchi

4.5 Photodynamic therapy for pythiosis

Layla Pires, Sandra de M. G. Bosco, Nelson F. da Silva Junior and Cristina Kurachi

PART 5 INFECTIOUS DISEASES

5.1 The canine and feline skin microbiome in health and disease

J. Scott Weese

5.2 Ulcerated and nonulcerated nontuberculous cutaneous mycobacterial granulomas in cats and dogs

Richard Malik, Bronwyn Smits, George Reppas, Caroline Laprie, Carolyn O’Brien and Janet Fyfe5.3 Prevalence of and risk factors for isolation of meticillin-resistant Staphylococcus spp. from dogs with pyoderma in northern California, USA

Nicole G. Eckholm, Catherine A. Outerbridge, Stephen D. White and Jane E. Sykes

5.4 Usefulness of cefovecin disk-diffusion test for predicting mecA gene-containing strains of Staphylococcus pseudintermedius and clinical efficacy of cefovecin in dogs with superficial pyoderma

Keita Iyori, Yoichi Toyoda, Kaori Ide, Toshiroh Iwasaki and Koji Nishifuji

5.5 Small Demodex populations colonize most parts of the skin of healthy dogs

Iván Ravera, Laura Altet, Olga Francino, Armand Sánchez, Wendy Roldán, Sergio Villanueva, Mar Bardagí and Lluís Ferrer

PART 6 ONCOLOGY

6.1 Advances in the management of skin cancer

Pamela D. Martin and David J. Argyle

6.2 Kinase dysfunction and kinase inhibitors

Cheryl A. London

6.3 The contribution of stem cells to epidermal and hair follicle tumours in the dog

Chiara Brachelente, Ilaria Porcellato, Monica Sforna, Elvio Lepri, Luca Mechelli and Laura Bongiovanni

6.4 Epithelial-to-mesenchymal transition: immunohistochemical investigation of related molecules in canine cutaneous epithelial tumours

Laura Bongiovanni, Alessandra D’Andrea, Mariarita Romanucci, Daniela Malatesta, Melissa Candolini, Leonardo D. Salda,

Luca Mechelli, Monica Sforna and Chiara Brachelente

6.5 Canine inflamed nonepitheliotropic cutaneous T-cell lymphoma: a diagnostic conundrum

Peter F. Moore, Verena K. Affolter and Stefan M. Keller

PART 7 EQUINE DERMATOLOGY

7.1 Comparison of hair follicle histology between horses with pituitary pars intermedia dysfunction and excessive hair growth and normal aged horses

Marie Innera° , Annette D. Petersen, Danielle R. Desjardins, Barbara A. Steficek, Edmund J. Rosser Jr and Harold C. Schott II

7.2 Equine sarcoidosis: clinical signs, diagnosis, treatment and outcome of 22 cases

Marianne M. Sloet van Oldruitenborgh-Oosterbaan and Guy C. M. Grinwis

PART 8 WORKSHOP REPORTS

Co-editors: Dr Karen L. Campbell, University of Illinois, Illinois, USA

Dr Kinga Gortel, Lake Country Veterinary Specialist Hospital, Lake Country, BC, Canada

8.1 Nonpruritic hair loss

R. Cerundolo and J. R. Rest

8.2 Dietary management of skin disease: elimination diets and dietary approach to canine allergic disease

D. N. Carlotti and R. G. Harvey

8.3 Fun with lasers

M. Boord and C. S. Nett-Mettler

8.4 Allergen-specific immunotherapy

A. Hillier and J. S. Pendergraft

8.5 Pododermatitis: canine interdigital follicular cysts and feline plasma cell pododermatitis

R. Muse and B. E. Wildermuth

8.6 Hot topics in zoonosis

J. S. Weese and C. C. Pye

8.7 Responsible use of antimicrobials

D. H. Lloyd and J. D. Littlewood

8.8 Refractory atopic dermatitis therapy

W. S. Rosenkrantz and C. L. Mendelsohn

8.9 Challenges in otitis

A. Burrows, S. Hobi and R. Albert

8.10 Allergy testing revisited

R. E. W. Halliwell and S. Gilbert

8.11 Epidermal barrier function

K. Nishifuji and P. Bizikova

8.12 The changing faces of parasite control

C. Taylor and K. Glos

8.13 Topical antimicrobial therapy

K. Bergvall and K. Varjonen

Index

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