Agmatine and Imidazolines : Their Novel Receptors and Enzymes

, by Piletz, John E.; Regunathan, Soundar; Ernsberger, Paul

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ISBN: 9781573314985 | 1573314986
Cover: Hardcover
Copyright: 3/1/2004

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Supplemental Materials

In Memoriam

xiii

Donald J. Reis

Preface

Keynote address: Relevance of Imidazoline Receptors and Agmatine to Psychiatry: A Decade of Progress

(19)

A. Halaris

J.E. Piletz

Part I. Agmatine: Basic and Molecular Aspects

Regulation of Inducible Nitric Oxide Synthase and Agmatine Synthesis in Macrophages and Astrocytes

(10)

Soundar Regunathan

John E. Piletz

Vertebrate Agmatinases: What Role Do They Play in Agmatine Catabolism?

(4)

Sidney M. Morris Jr.

Agmatine: At the Crossroads of the Arginine Pathways

(10)

Joseph Satriano

Gastrointestinal Uptake of Agmatine: Distribution in Tissues and Organs and Pathophysiologic Relevance

(8)

Gerhard J. Molderings

Anja Heinen

Sigrid Menzel

Friedrich Lubbecke

Jurgen Homann

Manfred Gothert

Structure-Activity Analysis of Guanidine Group in Agmatine for Brain Agmatinase

(12)

M.-J. Huang

S. Regunathan

M. Botta

K. Lee

E. McClendon

G.B. Yi

M.L. Pedersen

D.B. Berkowitz

G. Wang

M. Travagli

J.E. Piletz

Agmatine Crosses the Blood-Brain Barrier

(11)

J.E. Piletz

P.J. May

G. Wang

H. Zhu

Identification and Pharmacological Characterization of a Specific Agmatine Transport System in Human Tumor Cell Lines

(7)

Gerhard J. Molderings

Michael Bruss

Heinz Bonisch

Manfred Gothert

Part II. Agmatine: Function and Pre-Clinical Aspects

Neuropharmacokinetic and Dynamic Studies of Agmatine (Decarboxylated Arginine)

(24)

H. Oanh X. Nguyen

Cory J. Goracke-Postle

Lori L. Kaminski

Aaron C. Overland

Andrew D. Morgan

Carolyn A. Fairbanks

Effect of Agmatine on Acute and Mononeuropathic Pain

106

(10)

Feyza Aricioglu

Eylem Korcegez

Ayhan Bozkurt

Suleyman Ozyalcin

Spinal and Supraspinal Agmatine Activate Different Receptors to Enhance Spinal Morphine Antinociception

116

(11)

Sandra C. Roerig

Is Agmatine an Endogenous Factor Against Stress?

127

(6)

Feyza Aricioglu

Soundar Regunathan

John E. Piletz

Agmatine-Morphinc Interaction on Nociception in Mice

133

(3)

Eduardo Ruiz-Durantez

Javier Liorente

Isabel Ulibarri

Joseba Pineda

Luisa Ugedo

Is Agmatine an Endogenous Anxiolytic/Antidepressant Agent?

136

(5)

Feyza Aricioglu

Hale Altunbas

Effect of Agmatine on Electrically and Chemically Induced Seizures in Mice

141

(6)

Feyza Aricioglu

Bilge Kan

Okan Yillar

Eylem Korcegez

Kemal Berkman

Agmatine Inhibits Naloxone-Induced Contractions in Morphine-Dependent Guinea Pig Ileum

147

(5)

Feyza Aricioglu

Eser Ercil

Gul Dulger

Effect of Agmatine on the Time Course of Brain Inflammatory Cytokines After Injury in Rat Pups

152

(5)

Yangzheng Feng

Michael H. LeBlanc

Part III. Other Endogenous Ligands for Imidazoline Receptors

Endogenous β-Carbolines as Clonidine-Displacing Substances

157

(10)

E.S.J. Robinson

N.J. Anderson

J. Crosby

D.J. Nutt

A.L. Hudson

Comparative Effects of Efaroxan and β-Carbolines on the Secretory Activity of Rodent and Human β Cells

167

(8)

Noel G. Morgan

E. Jane Cooper

Paul E. Squires

Claire E. Hills

Christine A. Parker

Alan L. Hudson

Characterization of [3H]Harmane Binding to Rat Whole Brain Membranes

175

(5)

N.J. Anderson

E.S.J. Robinson

S.M. Husbands

P. Delagrange

D.J. Nutt

A.L. Hudson

Effect of Harmane on Mononeuropathic Pain in Rats

180

(5)

Feyza Aricioglu

Eylem Korcegez

Suleyman Ozyalcin

Inhibitory Effect of Harmane on Morphine-Dependent Guinea Pig Ileum

185

(5)

Feyza Aricioglu

Tijen Utkan

Effect of Harmane on the Convulsive Threshold in Epilepsy Models in Mice

190

(6)

Feyza Aricioglu

Okan Yillar

Eylem Korcegez

Kemal Berkman

Harmane Induces Anxiolysis and Antidepressant-Like Effects in Rats

196

(5)

Feyza Aricioglu

Hale Altunbas

No Evidence for Activation of α2-Adrenoceptors by Methanolic Extracts of Bovine Brain and Lung Containing Clonidine-Displacing Substance

201

(15)

D. Pinthong

D.A. Kendall

S.J. MacLennan

R.M. Eglen

V.G. Wilson

Complex Interaction of α2-Adrenoceptor Binding Sites with Bovine Brain and Lung Extracts Containing Clonidine-Displacing Substance

216

(6)

D. Pinthong

D.A. Kendall

V.G. Wilson

Endogenous Imidazoline Receptor Ligands Relax Rat Aorta by an Endothelium-Dependent Mechanism

222

(6)

Ian F. Musgrave

Andrea Van Der Zypp

Mathew Grigg

Colin J. Barrow

Part IV. I-1 Imidazoline Receptors

I1 Imidazoline Receptors Involved in Cardiovascular Regulation: Where Are We and Where Are We Going?

228

(6)

P. Bousquet

H. Greney

V. Bruban

S. Schann

J. D. Ehrhardt

L. Monassier

J. Feldman

Are Centrally Acting Imidazoline Agents Appropriate Therapy for Renovascular Hypertension?

234

(10)

Geoffrey A. Head

Sandra L. Burke

Cardiac Effects of Moxonidine in Spontaneously Hypertensive Obese Rats

244

(7)

S. Mukaddam-Daher

A. Menaouar

R. El-Ayoubi

J. Gutkowska

M. Jankowski

R.A. Velliquette

P. Ernsberger

The Role of I1-Imidazoline Receptors and α2-Adrenergic Receptors in the Modulation of Glucose and Lipid Metabolism in the SHROB Model of Metabolic Syndrome X

251

(11)

Richard J. Koletsky

Rodney A. Velliquette

Paul Ernsberger

Involvement of Forebrain Imidazoline and α2-Adrenergic Receptors in the Antidipsogenic Response to Moxonidine

262

(3)

Carina A.F. Andrade

Lisandra B. Oliveira

Gizele Martinez

Daniela C.F. Silva

Laurival A. De Luca Jr.

Jose V. Menani

Moxonidine Displays a Presynaptic Alpha-2-Adrenoceptor-Dependent Synergistic Sympathoinhibitory Action at Imidazoline-1 Receptors

265

(5)

Ulrich Schafer

Christof Burgdorf

Astrid Engelhardt

Walter Raasch

Thomas Kurz

Gert Richardt

Norepinephrine Release Is Reduced by I1-Receptors in Addition to α2-Adrenoceptors

270

(4)

Walter Raasch

Britta Jungbluth

Ulrich Schafer

Walter Hauser

Peter Dominiak

Normalization of Up-Regulated Cardiac Imidazoline I1-Receptors and Natriuretic Peptides by Chronic Treatment with Moxonidine in Spontaneously Hypertensive Rats

274

(5)

R. El-Ayoubi

A. Menaouar

J. Gutkowska

S. Mukaddam-Daher

Alpha2A-Adrenergic versus Imidazoline Receptor Controversy in Rilmenidine's Action: Alpha2A-Antagonism in Humans versus Alpha2A-Agonism in Rabbits

279

(4)

Gerhard J. Molderings

Heinz Bonisch

Michael Bruss

Manfred Gothert

BU98008, a Highly Selective Imidazoline1-Receptor Ligand

283

(5)

E.S.J. Robinson

R.E. Price

D.J. Nutt

A.L. Hudson

Apparent Absence of a Direct Renal Effect of Imidazoline Receptor Agonists

288

(8)

D.D. Smyth

D. Pirnat

B. Forzley

S.B. Penner

Atypical [3H]Clonidine Binding Sites in Human Caudate and Platelets on Cryostat-cut Sections

296

(6)

H. Zhu

A. Halaris

J.E. Piletz

Part V. I-2/I-3 Imidazoline Receptors

Novel Ligands for the Investigation of Imidazoline Receptors and Their Binding Proteins

302

(7)

A.L. Hudson

R.J. Tyacke

M.D. Lalies

N. Davies

D.P. Finn

O. Marti

E. Robinson

S. Husbands

M.C.W. Minchin

A. Kimura

D.J. Nutt

The Effects of Chronic Administration of Inhibitors of Flavin and Quinone Amine Oxidases on Imidazoline I1 Receptor Density in Rat Whole Brain

309

(14)

Andrew Holt

Kathryn G. Todd

Glen B. Baker

In Vivo Effects of the I2-Alkylating Agent BU99006 on the Immunodensity of Imidazoline Receptor Proteins in the Mouse Brain

323

(9)

Jesus A. Garcia-Sevilla

Marcel Ferrer-Alcon

Restoration of First-Phase Insulin Secretion by the Imidazoline Compound LY374284 in Pancreatic Islets of Diabetic db/db Mice

332

(9)

M.B. Brenner

J. Gromada

A.M. Efanov

K. Bokvist

H.-J. Mest

Effect of Postmortem Delay on Imidazoline Receptor-Binding Proteins in Human and Mouse Brain

341

(6)

John K. Ma

He Zhu

John E. Piletz

Association Between I1 Binding Sites and Monoamine Oxidase-B Activity in Platelets

347

(6)

H. Zhu

J.E. Piletz

Relationship Between Imidazoline2 Sites and Monoamine Oxidase

353

(4)

L.M. Paterson

R.J. Tyacke

D.J. Nutt

A.L. Hudson

Initial Evaluation of Novel Selective Ligands for Imidazoline2 Receptors in Rat Whole Brain

357

(4)

R.J. Tyacke

F. Saczewski

P. Tabin

J. Saczewski

D.J. Nutt

A.L. Hudson

Investigation of the Affinities of Two New β-Carbolines for Rat Brain Imidazoline2 Receptors

361

(3)

R.J. Tyacke

A. Lau

B. Grella

R.A. Glennon

D.J. Nutt

A.L. Hudson

Identification of an I2 Binding Protein From Rabbit Brain

364

(3)

A. Kimura

R.J. Tyacke

M.C.W. Minchin

D.J. Nutt

A.L. Hudson

In Vivo Estimation of Imidazoline2 Binding Site Turnover

367

(4)

L.M. Paterson

E.S.J. Robinson

D.J. Nutt

A.L. Hudson

Specificity of Nonadrenergic Imidazoline Binding Sites in Insulin-Secreting Cells and Relation to the Block of ATP-Sensitive K+ Channels

371

(7)

Timm Grosse-Lackmann

Bernd J. Zonkler

Ingo Rustenbeck

Part VI. IRAS Candidate Imidazoline Receptor

Moxonidine, a Mixed α2-Adrenergic and Imidazoline Receptor Agonist, Identifies a Novel Adrenergic Target for Spinal Analgesia

378

(8)

Laura S. Stone

Carolyn A. Fairbanks

George L. Wilcox

Evidence for Nonadrenoceptor Responses to Imidazoline Derivatives in the Porcine Isolated Rectal Artery

386

(6)

Minyan Wang

W.R. Dunn

S.L. Chan

B. Garfield

V.G. Wilson

Cell Signaling by Imidazoline-1 Receptor Candidate, IRAS, and the Nischarin Homologue

392

(8)

J.E. Piletz

G. Wang

H. Zhu

IRAS Is an Anti-Apoptotic Protein

400

(13)

Monique Dontenwill

John E. Piletz

Michael Chen

James Baldwin

Geraldine Pascal

Philippe Ronde

Laurence Dupuy

Hugues Greney

Ken Takeda

Pascal Bousquet

Assembly of PRR-Containing Receptors on Scaffolds: A Model for Imidazoline I1-Receptor Action

413

(6)

I.F. Musgrave

F.C. Dehle

J. Piletz

IRAS Splice Variants

419

(8)

J.E. Piletz

W. Deleersnijder

B.L. Roth

P. Ernsberger

H. Zhu

D. Ziegler

Intracellular Effect of Imidazoline Receptor on α2A-Noradrenergic Receptor

427

(12)

Michael J. Chen

He Zhu

John E. Piletz

Relationship between Platelet Imidazoline Receptor-Binding Peptides and Candidate Imidazoline-1 Receptor, IRAS

439

(8)

He Zhu

Jonathan Hayes

Michael Chen

James Baldwin

John E. Piletz

Index of Contributors

447

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Agmatine and Imidazolines : Their Novel Receptors and Enzymes

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